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Case-Control Inference of Interaction between Genetic and Nongenetic Risk Factors under Assumptions on Their Distribution
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Ji-Hyung Shin
Veröffentlicht/Copyright:
22. April 2007
In genetic association studies, there is increasing interest in understanding the joint effects of genetic and nongenetic factors. For rare diseases, the case-control study is a practical design, and logistic regression is the standard method of inference. However, the power to detect statistical interaction is a concern, even with relatively large samples. Under independence of genetic and nongenetic covariates, improved precision of interaction estimators is possible, but logistic regression does not make use of this assumption and consequently is not statistically efficient. In recent work to improve efficiency, profile likelihood methods have been used to develop semi-parametric inference that incorporates the independence assumption. We describe an alternate derivation of these estimators for rare diseases that is based on classic arguments from case-control inference. These arguments lead to a simplification in the variance estimator. We also describe a strategy for relaxing the independence assumption. Under either independence or the proposed dependence model, inference for association parameters is conveniently obtained by fitting a conditional logistic regression. The statistical properties of the proposed methodology are investigated by simulation.
Keywords: case-control study; genetic associations; gene-environment interaction; likelihood; semiparametric inference; conditional logistic regression
Published Online: 2007-4-22
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Schlagwörter für diesen Artikel
case-control study;
genetic associations;
gene-environment interaction;
likelihood;
semiparametric inference;
conditional logistic regression
Artikel in diesem Heft
- Article
- Accounting for Dependence in Similarity Data from DNA Fingerprinting
- Normalization of Dye Bias in Microarray Data Using the Mixture of Splines Model
- A Generalized Sidak-Holm Procedure and Control of Generalized Error Rates under Independence
- Using Duplicate Genotyped Data in Genetic Analyses: Testing Association and Estimating Error Rates
- Likelihood-Based Inference for Multi-Color Optical Mapping
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- Super Learning: An Application to the Prediction of HIV-1 Drug Resistance
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- A Bayesian Model of AFLP Marker Evolution and Phylogenetic Inference
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