Effect of Temperature on the Supramolecular Behavior of Antidepressant Drug Amitriptyline Hydrochloride in the Presence of Nonionic Surfactants (Tweens and Brijs) as Pharmaceutical Excipients
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Abstract
The aggregational and adsorption behavior of an important antidepressant amphiphilic drug amitriptyline hydrochloride have been studied in the presence of nonionic surfactants at different temperatures by tensiometry. By using regular solution theory and other thermodynamic models, different physicochemical properties such as critical micellar concentration, micellar composition, interfacial adsorption, energetic parameters (free energy, enthalpy, entropy) of micellization are evaluated. The data clearly depict that there is strong interaction between the amitriptyline hydrochloride and nonionic surfactants. Steric factor appears to play an important role during interaction when surfactant molecular structure varies in size of the head group and chain length of the hydrophobic part. The temperature has been observed to be vital in controlling the dehydration and thermal solubility which, in turn, makes environment conducive for aggregational behavior of the drug-surfactant mixtures in aqueous solution.
© by Oldenbourg Wissenschaftsverlag, München, Germany
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Articles in the same Issue
- Synthesis of Small Carbon Nanoparticles in a Microwave Plasma Flow Reactor
- Effect of Structural and Lattice Oxygen Changes on the Properties of CuO/CeO2 Catalysts for High-Temperature Water-Gas shift of H2-rich Coal-Derived Synthesis Gas
- The Effect of Heat Treatments and Degradation Behavior of High-Rate Dischargeability in Ti-V-based Alloys as Anode Materials for Nickel-Metal-Hydride Batteries
- Thermodynamic and Adsorption Behaviour of Vitamin B1 as a Corrosion Inhibitor for AISI 4130 Steel Alloy in HCl Solution
- Investigation of Cellulose and Tin Oxide Hybrid Composite as a Disposable pH Sensor
- Surface Dilational Properties of Sodium 4-(1-methyl)-Alkyl Benzene Sulfonates: Effect of Alkyl Chain Length
- Interaction between Zwitterionic Surfactants and Amphiphilic Drug: A Tensiometric Study
- Effect of Temperature on the Supramolecular Behavior of Antidepressant Drug Amitriptyline Hydrochloride in the Presence of Nonionic Surfactants (Tweens and Brijs) as Pharmaceutical Excipients
- Tautomerism of Neutral α-Tropolone and its Protonated and Deprotonated Forms
