Kinetics and Mechanism of Oxidation of Chloramphenicol — an Antibiotic Drug by Diperiodatocuprate(III) in Aqueous Alkaline Medium
-
Rajeshwari V. Hosahalli
Abstract
The kinetics of oxidation of chloramphenicol (CHP) by diperiodatocuprate(III) (DPC) in aqueous alkaline medium at a constant ionic strength of 0.10 mol dm-3 was studied spectrophotometrically. The reaction between DPC and CHP in alkaline medium exhibits 1:2 stoichiometry (CHP: DPC). The main oxidation products were identified by spot test, IR, NMR and GCMS spectral studies. The reaction is of first order in DPC and CHP concentrations. As the alkali concentration increases the rate of reaction increases with fractional order dependence on alkali concentration. Increase in periodate concentration decreases the rate. A suitable mechanism is proposed. The reaction constants involved in the different steps of the mechanism were calculated. The activation parameters with respect to slow step of the mechanism are computed and discussed. Thermodynamic quantities are also determined.
© by Oldenbourg Wissenschaftsverlag, Dharwad- 580003, Germany
Articles in the same Issue
- Relation between Quantum Thermodynamics and Classical Thermodynamics
- DFT Study on the Complexation of Cs+ with Benzo-18-crown-6
- Uniform and Pitting Corrosion Processes of Al, Al-6061, Al-Zn and Al-Cu Alloys Exposed to SCN- Solutions and the Effect of Some Inorganic Anions
- Sol–gel Synthesis and Characterization of Nanostructured ZnO Obtained in the Ionic Liquid [BMP]TFSA and in Isopropanol
- Oscillatory Behavior in the CO-oxidation over Bulk Ruthenium Dioxide — the Effect of the CO/O2 Ratio
- Transport Studies of Some 1:1 Copper(I) Perchlorate Complexes in Acetonitrile-Dimethylsulphoxide Mixtures
- Kinetics and Mechanism of Oxidation of Chloramphenicol — an Antibiotic Drug by Diperiodatocuprate(III) in Aqueous Alkaline Medium
- Kinetics and Mechanism of Oxidation of Gabapentin (Neurontin) Anion by Alkaline Diperiodatonickelate(IV) — A Free Radical Intervention
- Effect of CTAB Micelle on the Oxidation of L-Leucine by N-Bromophthalimide: a Kinetic Study
- Determination of Steric Effect on the Esterification of Different Alcohols with Propanoic Acid over Cation-exchange Resin Catalyst Dowex 50Wx4
Articles in the same Issue
- Relation between Quantum Thermodynamics and Classical Thermodynamics
- DFT Study on the Complexation of Cs+ with Benzo-18-crown-6
- Uniform and Pitting Corrosion Processes of Al, Al-6061, Al-Zn and Al-Cu Alloys Exposed to SCN- Solutions and the Effect of Some Inorganic Anions
- Sol–gel Synthesis and Characterization of Nanostructured ZnO Obtained in the Ionic Liquid [BMP]TFSA and in Isopropanol
- Oscillatory Behavior in the CO-oxidation over Bulk Ruthenium Dioxide — the Effect of the CO/O2 Ratio
- Transport Studies of Some 1:1 Copper(I) Perchlorate Complexes in Acetonitrile-Dimethylsulphoxide Mixtures
- Kinetics and Mechanism of Oxidation of Chloramphenicol — an Antibiotic Drug by Diperiodatocuprate(III) in Aqueous Alkaline Medium
- Kinetics and Mechanism of Oxidation of Gabapentin (Neurontin) Anion by Alkaline Diperiodatonickelate(IV) — A Free Radical Intervention
- Effect of CTAB Micelle on the Oxidation of L-Leucine by N-Bromophthalimide: a Kinetic Study
- Determination of Steric Effect on the Esterification of Different Alcohols with Propanoic Acid over Cation-exchange Resin Catalyst Dowex 50Wx4
