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Barrier Trees of Degenerate Landscapes
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April 21, 2008
The heights of energy barriers separating two (macro-)states are useful for estimating transition frequencies. In non-degenerate landscapes the decomposition of a landscape into basins surrounding local minima connected by saddle points is straightforward and yields a useful definition of macro-states. In this work we develop a rigorous concept of barrier trees for degenerate landscapes. We present a program that efficiently computes such barrier trees, and apply it to two well known examples of landscapes.
Published Online: 2008-04-21
Published in Print: 2002-02
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Articles in the same Issue
- Structure-Function Analysis of RNAs Generated by In Vivo and In Vitro Selection
- Randomness, Structural Uniqueness, Modularity and Neutral Evolution in Sequence Space of Model Proteins
- Barrier Trees of Degenerate Landscapes
- RNA Pathfinder – Global Properties of Neutral Networks
- Matching and Significance Evaluation of Combined Sequence-Structure Motifs in RNA
- Recombination Spaces, Metrics, and Pretopologies
- Towards a Calculus of Biological Networks
- Kinetics and Mechanism of the Heterogeneous Oxidation of N-Substituted-p-Phenylenediamines over Supported Zinc Oxide
