Simple and safe production of yttrium-90 from a new type of 90Sr/90Y generator
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Jin Du
Abstract
Yttrium-90 (90Y) has attracted much research attention in targeted radionuclide therapy because its many favorable properties and availability from a long shelf-life generator system. Although numerous generator systems have been developed for the production of 90Y, a common disadvantage is that the 90Y is not eluted in an ionic form suitable for direct labeling of chelating agents bound to useful targeting molecules. In this study, we have adapted previously published procedures and developed a 740 MBq (20 mCi) of generator system in which the parent activity 90Sr was retained on a cation exchange resin, while the daughter 90Y activity was eluted with acetate buffer solution and used directly to label useful radioconjugates without further manipulations. A safety column, not loaded with 90Sr, was connected in series with the generator resulting in an eluate free of any 90Sr breakthrough for at least eight months. The features of this new generator make it suitable for clinical applications.
© 2005 Oldenbourg Wissenschaftsverlag GmbH
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- Thermochemistry of selected trivalent lanthanide and americium compounds: orthorhombic and hexagonal hydroxycarbonates
- Simple and safe production of yttrium-90 from a new type of 90Sr/90Y generator
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Articles in the same Issue
- Transmutation experiments on 129I, 139La and 237Np using the Nuclotron accelerator
- Electrochemical redox reactions of uranium(VI) complexes with multidentate ligands in dimethyl sulfoxide
- Solubility of ThO2·xH2O(am) in carbonate solution and the formation of ternary Th(IV) hydroxide-carbonate complexes
- Eu(III), Sm(III), Np(V), Pu(V), and Pu(IV) sorption to calcite
- Thermochemistry of selected trivalent lanthanide and americium compounds: orthorhombic and hexagonal hydroxycarbonates
- Simple and safe production of yttrium-90 from a new type of 90Sr/90Y generator
- Radiometric method for the study of the corrosion reactions of steel samples in strongly acidic media
- Comparison of techniques for measuring ion exchange selectivities in zeolites
