Bioavailability of 99mTc-paclitaxel-glucuronide (99mTc-PAC-G)
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Fazilet Zumrut Biber Muftuler
Abstract
An antitumor agent paclitaxel (PAC) has been proved to be efficient in the treatment of breast and ovarian cancer. Glucuronic acid-derived paclitaxel compound [paclitaxel-glucuronide (PAC-G)] was enzymatically synthesized using microsome preparate separated from rat livers. The biodistribution mechanism of PAC-G in healthy female Albino Wistar rats has been investigated. The expected structure is confirmed according to LC/MS results, and the possible attachment is to C2-hydroxyl group. PAC-G was labeled with 99mTc and the radiochemical yield of radiolabeled compound (99mTc-PAC-G) was 98.0±02.74 (n=9). The range of the breast/blood and breast/muscle ratios is approximately between 3 and 35 in 240ߙmin. All these experimental studies indicate that 99mTc-PAC-G may potentially be used in breast tissue as an imaging agent.
© by Oldenbourg Wissenschaftsverlag, 35100 Bornova, Izmir, Germany
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Artikel in diesem Heft
- Influence of humic acid on the Am(III) sorption onto kaolinite
- Photoluminescent nano-sized ternary and quaternary complexes of thorium(IV)
- Solubility of ThO2·xH2O(am) in the presence of gluconate
- Liquid chromatographic behavior of lanthanides and actinides on monolith supports
- A novel synthesis of the N-13 labeled atmospheric trace gas peroxynitric acid
- A comparative study on the effect of solvent on nucleophilic fluorination with [18F]fluoride: protic solvents as co-solvents in SN2 and SNAr reactions
- Bioavailability of 99mTc-paclitaxel-glucuronide (99mTc-PAC-G)
- New 99mTc(CO)3(NNO) complexes in the development of 5HT1A receptor imaging agents
