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Development of [111In]-DTPA-buserelin for GnRH receptor studies
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A. R. Jalilian
Published/Copyright:
April 19, 2010
Abstract
Buserelin was successively labeled with [111In]-Indium chloride after residuation with DTPA-dianhydride. Radio-chromatography showed an overall radiochemical purity of >90% (RTLC) and >95% (HPLC) at optimized conditions after labeling (specific activity: 400−450 GBq/M). The serum stability of the tracer was determined up to 24 h. The biodistribution of the tracer was determined in normal rats showing significant breast and ovaries uptakes 60 min post injection. MCF-7 cell binding of the tracer was >98%. A significant testes uptake was demonstrated in normal male rats using SPECT studies.
Published Online: 2010-04-19
Published in Print: 2010-02
© by Oldenbourg Wissenschaftsverlag, München, Germany
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Articles in the same Issue
- A new value of 93Zr half-life
- Complexation of plutonium(IV) with fluoride at variable temperatures
- Determination of the stability constants of nitrate complexes of Np(V) and Pu(V) using CE-ICP-MS
- Nanoscale UO2 and novel complex U(IV)-sulphate phase formation from electrolytically reduced uranyl sulphate solutions
- Method validation in solvent extraction for 210Po determination from groundwaters
- Random coincidence summing of gamma rays and dead time count loss corrections in HPGe-detector based gamma ray spectrometry
- Chemical effects of neutron irradiation on germanium thiocompounds
- Development of [111In]-DTPA-buserelin for GnRH receptor studies
- Determination of rare earth and other trace impurities in high purity gadolinium oxide
