Comparative studies of S-bridged complexes of 99mTc with fac(S)-[M(aet)3] (M=RhIII, IrIII; aet=2-aminoethanethiolate)
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Nagina Amir
Abstract
fac(S)-[Ir(aet)3] (aet=2-aminoethanethiolate) is N3S3 metalloligand, which forms S-bridged polynuclear complexes with transition metal ions. A complex analogous to [Re{Ir(aet3)}2]3+ was formed by the reaction of 99mTcO4Na and fac(S)-[Ir(aet)3] in the presence of SnCl22H2O. A simple method for radiollabelling of fac(S)-[Ir(aet)3] with 99mTc was developed with radiolabelling efficiency higher than 99%. Effects of SnCl2·2H2O concentration, time and pH on the radiolabelling efficiency were determined and compared with 99mTc-[Rh(aet)3]. 99mTc-[Ir(aet)3] was also characterized by electrophoresis, HPLC, biodistribution studies in rats and scintigraphy in rabbit. Higher uptake by kidneys showed rapid distribution of the labelled fac (S)-[Ir(aet)3]. Scintigrams show that liver, bladder and skeletal uptake were significant. The results of biodistribution showed that 99mTc-[Ir(aet)3] uptake is quite rapid as compared to 99mTc-[Rh(aet)3].
© by Oldenbourg Wissenschaftsverlag, München, Germany
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- Proton induced reactions on 89Y with particular reference to the production of the medically interesting radionuclide 89Zr
- Recovery of U and Pu from simulated spent nuclear fuel by adducts of organic reagents with HNO3 followed by their separation from fission products by countercurrent chromatography
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- Leaching of 53 MW/d kg U spent nuclear fuel in a flow-through reactor
- Investigation of the radiolytic stability of a CyMe4-BTBP based SANEX solvent
- Separation of no-carrier-added arsenic-77 from neutron irradiated germanium
- Comparative studies of S-bridged complexes of 99mTc with fac(S)-[M(aet)3] (M=RhIII, IrIII; aet=2-aminoethanethiolate)
- Characterization of pottery from Cerro de Las Ventanas, Zacatecas, México
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