A novel 188W/188Re electrochemical generator with potential for medical applications
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Rubel Chakravarty
Abstract
Rhenium-188 is a well recognized therapeutic radionuclide and its use in a variety of applications has been reported. The current methods of obtaining “no-carrier added” 188Re from conventional alumina based generators require 188W of very high specific activity for obtaining reasonable quantities of 188Re in an adequately concentrated form. We have developed a simple electrochemical separation technique adaptable for using low specific activity 188W, for the separation of 188Re from 188W, and obtain 188Re amenable for radiolabeling biomolecules. The overall decay corrected yield of 188Re was >70%. The recovered 188Re had high radiochemical (>97%) and radionuclidic purity (>99.99%). The suitability of the 188Re for radiolabeling was demonstrated by its use for the complexation of DMSA and HEDP with labeling yields >98%. Repeated separation of 188Re from a stock solution of 188W could be demonstrated for a period of 70 d. The preliminary results suggest that the process can be scaled up to higher activity levels and suggest that this strategy can be further explored for the development of electrolytic type 188W/ 188Re generator suitable for clinical applications.
© by Oldenbourg Wissenschaftsverlag, München, Germany
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Articles in the same Issue
- Influence of pH and metal ion loading on the Cm(III) humate complexation: a time resolved laser fluorescence spectroscopy study
- Radiotracer study of thorium complexation with humic acid at pH 2–11 using free-liquid electrophoresis
- Experimental and modeling studies of Eu(III) sorption on TiO2
- Extraction of uranium(VI) with diamides of dipicolinic acid from nitric acid solutions
- Extraction behavior of short-lived isotopes of Mo/W using α-benzoinoxime: A model system for the study of seaborgium
- Production of 95gTc via95Ru decay
- A novel 188W/188Re electrochemical generator with potential for medical applications
- Influence of dose rate on the radiolytic stability of a BTBP solvent for actinide(III)/lanthanide(III) separation
- Study of some Ayurvedic Indian medicinal plants for the essential trace elemental contents by instrumental neutron activation analysis and atomic absorption spectroscopy techniques
- Epithermal neutrons activation analysis, radiochemical and radiometric investigations of evaporitic deposits of Slanic-Prahova (Romania) salt mine
