Preparation and biological evaluation of [67Ga]-labeled-superparamagnetic nanoparticles in normal rats
-
A. R. Jalilian
Abstract
Gallium-67 labeled superparamagnetic iron oxide nanoparticles ([ 67Ga]-SPION were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles (SPION) with narrow size distribution were synthesized by a co-precipitation technique using ferrous salts at Fe3+/Fe2+=2 molar ratio followed by structure identification using XRD, TGA, DSC, VSM, HRSEM, TEM and FT-IR techniques (≈5 nm diameter). In order to trace SPION bio-distribution, the radiolabeled iron oxide nanoparticles were prepared using 67Ga with a high labeling efficiency (over 96%, RTLC method) and they also showed an excellent stability at room temperature for at least 4 d. The biodistribution of the radiolabeled SPION was checked in normal male rats up to 24 h compared to free Ga3+ cation biodistribution. The data strongly support the alteration of the tracer accumulation in reticuluendothelial system while the stability of the complex is highly retained.
© by Oldenbourg Wissenschaftsverlag, München, Germany
Articles in the same Issue
- Activity standardization of 41Ca by means of liquid scintillation counting
- Development of extraction chromatographic separation procedures for the simultaneous determination of actinides
- Leach rates of uranium and thorium from murataite ceramics
- Kinetics and thermodynamics studies for the removal of Co2+ and Cs+ from aqueous solution by sand and clay soils
- Potential interferences on the pertechnetate-sulfide immobilization reaction
- Sorption profile of cadmium ions onto styrene-divinylbenzene copolymer beads
- Preparation and biological evaluation of [67Ga]-labeled-superparamagnetic nanoparticles in normal rats
- Preparation, quality control and biological evaluation of 99mTc-labelled cationic steroid antibiotic (CSA-13)
Articles in the same Issue
- Activity standardization of 41Ca by means of liquid scintillation counting
- Development of extraction chromatographic separation procedures for the simultaneous determination of actinides
- Leach rates of uranium and thorium from murataite ceramics
- Kinetics and thermodynamics studies for the removal of Co2+ and Cs+ from aqueous solution by sand and clay soils
- Potential interferences on the pertechnetate-sulfide immobilization reaction
- Sorption profile of cadmium ions onto styrene-divinylbenzene copolymer beads
- Preparation and biological evaluation of [67Ga]-labeled-superparamagnetic nanoparticles in normal rats
- Preparation, quality control and biological evaluation of 99mTc-labelled cationic steroid antibiotic (CSA-13)
