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Simple and fully automated preparation of [carbonyl-11C]WAY-100635
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Wolfgang Wadsak
Published/Copyright:
September 25, 2009
So far, [carbonyl-11C]WAY-100635 is the PET-tracer of choice for 5HT1A-receptor-imaging. Since the preparation is still a challenge, we aimed at (1) the evaluation of various essential parameters for the successful preparation, (2) the simplification of the radiosynthesis and (3) the establishment of a safe and fully automated system. The preparation is based on a commercial synthesizer and all chemicals are used without further processing. We found a low failure rate (7.7%), high average yield (4.0 ± 1.0 GBq) and a specific radioactivity of 292 ± 168 GBq/μmol (both at the end of synthesis, EOS).
Received: 2006-11-15
Accepted: 2007-1-9
Published Online: 2009-9-25
Published in Print: 2007-7-1
© Oldenbourg Wissenschaftsverlag
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Articles in the same Issue
- Study of Np speciation in citrate medium
- Solubility kinetics of a synthetic uranium(VI) oxide at different pH and controlled O2 partial pressure and evaluation of substantial interface properties
- Recovery of actinides and lanthanides from high-level liquid waste by extraction chromatography using TODGA+TBP impregnated resins
- Dissolution and electrochemical properties of molybdenum carbide (Mo2C) in basic solutions
- Modeling batch kinetics of cesium, cobalt and strontium ions adsorption from aqueous solutions using hydrous titanium oxide
- Simple and fully automated preparation of [carbonyl-11C]WAY-100635
- Assessment of atmospheric pollution level using Asclepias procera leaves as biomonitor
