Radiobromination of closo-dodecaborate anion. Aspects of labelling chemistry in aqueous solution using Chloramine-T
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Vladimir Tolmachev
Summary
Closo-dodecaborate dianion is a three-dimensional aromatic inorganic molecule, which can be easily halogenated forming a stable halogen-boron bond. Derivatives of closo-dodecaborate were considered as a convenient chemical form of delivery of enriched 10B to malignant tumors for boron neutron capture therapy (BNCT). Some properties of closo-dodecaborate (hydrophilicity, strength of halogen-boron bond, charge at lysosomal pH) make it attractive as a potential prosthetic group for attachment of radioactive halogens to tumor-targeting proteins. Bromine radioisotopes possess a variety of useful nuclear characteristics, and can be used in different areas of clinical diagnostics and therapy. In this work, a basic chemistry of closo-dodecaborate radiobromination was studied. It was found, that di(triethylamonium) dodecahydro-closo-dodecaborate can be labelled in high yield, more then 90%, in a wide pH range. By decreasing the pH, the bromination can be directed to closo-dodecaborate in the presence of phenolic compounds. The results of the study indicate a possibility of using the radioactive bromine label for investigation of pharmacokinetics of boronated compounds for BNCT.
© Oldenbourg Wissenschaftsverlag, München
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Articles in the same Issue
- Charge and mass distribution in 7Li induced fission of 232Th
- Direct evidence for enhanced inner-sphere chloro complexation of Eu(III) and Cm(III) in anion exchange resin phase studied by time-resolved laser-induced fluorescence spectroscopy
- Plutonium separation by solvent extraction for the determination by photon electron rejecting alpha liquid spectrometry
- Influence of aggregation on the extraction of trivalent lanthanide and actinide cations by purified Cyanex 272, Cyanex 301, and Cyanex 302
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- Electrochemical separation and purification of yttrium-86
- Radiobromination of closo-dodecaborate anion. Aspects of labelling chemistry in aqueous solution using Chloramine-T
- Metal-ion speciation in blood plasma incorporating the water-soluble polymer, polyethyleneimine functionalised with methylenephosphonate groups, in therapeutic radiopharmaceuticals
