Pentavalent rhenium-188 dimercaptosuccinic acid: a new kit formulation and its initial evaluation in mice
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Pentavalent rhenium-188 dimercaptosuccinic acid [188Re(V)DMSA] is a β-emitting radiopharmaceutical that has been proposed for the treatment of painful bone metastases, medullary thyroid carcinoma and other soft tissue tumours. In this study the development of a kit formulation for convenient, routine preparation of 188Re(V)DMSA is presented. The kit contains all the ingredients in a single vial and its reconstitution with 188Re perrhenate, up to 4;mL, produces 188Re(V)DMSA in high radiochemical purity, suitable for clinical application. 188Re(V)DMSA prepared by this kit method was evaluated in mice and resulted in a biodistribution pattern similar to that of 99mTc(V)DMSA.
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Articles in the same Issue
- Simultaneous production of 28Mg and 47Ca by high-energy heavy-ion irradiation for applications in biology
- Thermodynamic model for the solubility of PuO2(am) in the aqueous Na+-H+-OH--Cl--H2O-ethylenediaminetetraacetate system
- A kinetic model for the oxidation of U(IV) to U(VI) with O2: Determination of stability constants via oxidation kinetic experiments
- Fluorescence spectroscopy of U(VI) in the presence of perchlorate ions
- Liquid-liquid extraction of plutonium and americium by cekanoic acid from alkaline medium
- Study of the interaction of Pu(IV) and Np(IV,V,VI) with Fe hydroxides to predict the behavior of actinides in environmental media
- Multitracer studies on the effects of model acid rain on the adsorption of trace elements on soils
- Absorption of iodine from aqueous solutions on nuclear reactors alloys
- Pentavalent rhenium-188 dimercaptosuccinic acid: a new kit formulation and its initial evaluation in mice
- Ortho-positronium annihilation parameters in polyvinyl alcohol films with various degrees of polymerization, saponification and crystallinity
