223Ra for endoradiotherapeutic applications prepared from an immobilized 227Ac/227Th source
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Gjermund Henriksen
A method is described for the production of 223Ra (t1/2=11.4 d) in a quality useful for endoradiotherapeutic applications. The method is based on a long term operating generator with a source of 227Ac (t1/2=21.7 years), from which 223Ra is eluted. The 227Ac was isolated from a 231Pa source using the f-element selective extraction chromatographic material TRU-resin. The purified 227Ac/227Th source was subsequently applied to another extraction chromatographic resin, containing the extractant P,P′-di(2-ethylhexyl)methanediphosphonic acid on silica (Dipex-2) and used as a generator for 223Ra. From the generator column, the yield of 223Ra was about 60 kBq per 100 kBq of 227Ac with a highly effective separation of 223Ra from the precursors. In production runs, the activity of 227Ac was found to be 6×10-6 relative to the eluted activity of 223Ra. By using a second column of Dipex-2 for additional purification, the activity of Ac was reduced to below 7×10-8 relative to 223Ra with nearly quantitative recovery of 223Ra. The described procedure resulted in a high purity 223Ra preparation, potentially useful in, e.g., targeted radiotherapy of tumors.
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Articles in the same Issue
- Sequential separation of americium, curium, plutonium, neptunium and uranium in various matrices from the electrometallurgic treatment of spent-nuclear fuel
- Supercritical fluid extraction of plutonium and americium from soil using thenoyltrifluoroacetone and tributylphosphate complexation
- A comparison of the extraction of carrier-free 176,177W and 99Mo with that of U, Th, Am, Cm, La, Ce, Tm, Yb, Lu, and Hf into tri-n-octyl amine in toluene from nitric, phosphoric, and sulphuric acid media
- EXAFS investigation of uranium(VI) complexes formed at Bacillus cereus and Bacillus sphaericus surfaces
- Thorium isotope fractionation in the dissolution of inorganic samples by a microwave method
- Diffusion of 99Tc in granite: A small scale laboratory simulation experiment
- Migration of 99Tc in unsaturated Chinese loess under artificial rainfall condition: an in situ test
- Separation and speciation of fission products by zirconium phosphate prepared by solid-solid reaction
- Interaction study between Ca2+ and humic acids in brine media
- 223Ra for endoradiotherapeutic applications prepared from an immobilized 227Ac/227Th source
