Moringa oleifera: a multifunctional botanical resource for sustainable agriculture, nutrition, and therapeutic applications, a review

References

1. Lykogianni, M, Bempelou, E, Karamaouna, F, Aliferis, KA. Do pesticides promote or hinder sustainability in agriculture? The challenge of sustainable use of pesticides in modern agriculture. Sci Total Environ 2021;795:148625. https://doi.org/10.1016/j.scitotenv.2021.148625.Search in Google Scholar PubMed

2. Mishra, AK, Arya, R, Tyagi, R, Grover, D, Mishra, J, Vimal, SR, et al.. Non-judicious use of pesticides indicating potential threat to sustainable agriculture. In: Sustainable agriculture reviews 50: emerging contaminants in agriculture; 2021:383–400 pp.10.1007/978-3-030-63249-6_14Search in Google Scholar

3. Tang, FH, Lenzen, M, McBratney, A, Maggi, F. Risk of pesticide pollution at the global scale. Nat Geosci 2021;14:206–10. https://doi.org/10.1038/s41561-021-00712-5.Search in Google Scholar

4. Baker, BP, Green, TA, Loker, AJ. Biological control and integrated pest management in organic and conventional systems. Biol Control 2020;140:104095. https://doi.org/10.1016/j.biocontrol.2019.104095.Search in Google Scholar

5. Patil, SV, Mohite, BV, Marathe, KR, Salunkhe, NS, Marathe, V, Patil, VS. Moringa tree, gift of nature: a review on nutritional and industrial potential. Curr Pharmacol Rep 2022;8:262–80. https://doi.org/10.1007/s40495-022-00288-7.Search in Google Scholar PubMed PubMed Central

6. Meena, R, Prajapati, SK, Nagar, R, Porwal, O, Nagar, T, Tilak, VK, et al.. Application of M. oleifera in dentistry. Asian J Dent Health Sci 2021;1:10–3. https://doi.org/10.22270/ajdhs.v1i1.5.Search in Google Scholar

7. Gandji, K, Chadare, FJ, Idohou, R, Salako, VK, Assogbadjo, AE, Kakaï, RG. Status and utilisation of M. oleifera Lam: a review. Afr Crop Sci J 2018;26:137–56. https://doi.org/10.4314/acsj.v26i1.10.Search in Google Scholar

8. Pérez-Rivera, EP, Montes-Ávila, J, Castro-Tamayo, CB, Portillo-Loera, JJ, Castillo-López, RI. Agronomical aspects of M. oleifera (Moringa). In: Biological and pharmacological properties of the genus Moringa. CRC Press; 2021:39–63 pp.10.1201/9781003108863-3Search in Google Scholar

9. Minakshi, J, Kumari, N, Kumar, R, Kumar, A, Rani, B, Phogat, DS, et al.. Moringa (M. oleifera L.): an underutilized and traditionally valued tree holding remarkable potential. J Hortic Sci 2021;16:1–13. https://doi.org/10.24154/jhs.2021.v16i01.001.Search in Google Scholar

10. Mashamaite, CV, Ramatsitsi, MN, Manyevere, A. M. oleifera Lam.: a versatile climate-smart plant for nutritional security and therapeutic usage in semi-arid regions. J Agric Food Res 2024:101217. https://doi.org/10.1016/j.jafr.2024.101217.Search in Google Scholar

11. Liu, R, Liu, J, Huang, Q, Liu, S, Jiang, Y. M. oleifera: a systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity. J Pharm Pharmacol 2022;74:296–320. https://doi.org/10.1093/jpp/rgab131.Search in Google Scholar PubMed

12. Madrigales-Reátiga, LF, Gutiérrez-Dorado, R, Perales-Sánchez, JXK, Reyes-Moreno, C. The Moringa genus: botanical and agricultural research. In: Biological and pharmacological properties of the Genus Moringa. CRC Press; 2021:1–20 pp.10.1201/9781003108863-1Search in Google Scholar

13. Peñalver, R, Martínez-Zamora, L, Lorenzo, JM, Ros, G, Nieto, G. Nutritional and antioxidant properties of M. oleifera leaves in functional foods. Foods 2022;11:1107. https://doi.org/10.3390/foods11081107.Search in Google Scholar PubMed PubMed Central

14. Si, A, Kyawphyo, A. Changing perceptions of ornamental plants in Urban Yangon, Myanmar. Plants 2025;14:552. https://doi.org/10.3390/plants14040552.Search in Google Scholar PubMed PubMed Central

15. Ndhlovu, PT, Mokgehle, SN, Kola, ME, Chauke, S, Falemara, BC, Otang-Mbeng, W. The contribution of underutilized fruits and vegetables to enhanced food and nutrition security: a review. Food Secur Nutr 2025:4–33.10.1201/9781003469766-2Search in Google Scholar

16. Verpoorte, R, Kim, HK. Natural products analysis through time: from past achievements to future prospects. Nat Prod Isol Identif: Methods Protoc 2025:3–13. https://doi.org/10.1007/978-1-0716-4350-1_1.Search in Google Scholar PubMed

17. Sarfraz, M, Alam, F, Din, KM, Malik, S, Quddoos, A. Pharmacognostic characterization of Dicleptera chinensis by scanning electron microscopy, light microscopy, and analytical techniques. Microsc Res Tech 2024;87:279–90. https://doi.org/10.1002/jemt.24429.Search in Google Scholar PubMed

18. Hussain, SM, Bano, AA, Ali, S, Rizwan, M, Adrees, M, Zahoor, AF, et al.. Substitution of fishmeal: highlights of potential plant protein sources for aquaculture sustainability. Heliyon 2024;10:e26573. https://doi.org/10.1016/j.heliyon.2024.e26573.Search in Google Scholar PubMed PubMed Central

19. Ivanova, S, Sukhikh, S, Popov, A, Shishko, O, Nikonov, I, Kapitonova, E, et al.. Medicinal plants: a source of phytobiotics for the feed additives. J Agric Food Res 2024:101172. https://doi.org/10.1016/j.jafr.2024.101172.Search in Google Scholar

20. Arsalan, MZUH, Hussain, SM, Ali, B, Ahmad, B, Qurban, M, Naeem, A, et al.. Effect of M. oleifera leaf meal on mineral contents of Labeo rohita fingerlings. Pakistan J Zool 2023:1–7. https://doi.org/10.17582/journal.pjz/20230413200442.Search in Google Scholar

21. Maqsood, S, Naz, S, Sikandar, A, Arooj, S, Fahad Alrefaei, A, Israr, M. Additive effect of M. oleifera leaf meal and pomegranate (Punica granatum) peel powder on productive performance, carcass attributes and histological morphology of ileum in Japanese quails. J Appl Anim Res 2024;52:1–7. https://doi.org/10.1080/09712119.2024.2319269.Search in Google Scholar

22. Choudhary, A, Choudhary, R, Dadarwal, P. Genetically modified (GM) vegetables. Mon Peer Rev Mag Agric Allied Sci 2024;66.Search in Google Scholar

23. Rodríguez, RP, Díaz-Domínguez, Y, Tobío-Pérez, I, Ortiz-Alvarez, M, Hernández, JS. Production of biodiesel from Jatropha curcas oil. In: The production of biodiesel and related fuel additives. Bentham Science Publishers; 2024:103–53 pp.10.2174/9789815196740124060006Search in Google Scholar

24. Tebe, UCK, Tangka, JK, Djoukeng, HG, Kamdem, BM, Folepe, EA. Effects of extraction parameters on the yield of oils from non-edible seeds of Bauhinia variegata and Pachira glabra. Heliyon 2024;10:1–10.10.1016/j.heliyon.2024.e30777Search in Google Scholar PubMed PubMed Central

25. Masitlha, EP, Seifu, E, Teketay, D. Nutritional composition and mineral profile of leaves of M. oleifera provenances grown in Gaborone, Botswana. Food Prod, Process Nutr 2024;6:3. https://doi.org/10.1186/s43014-023-00183-8.Search in Google Scholar

26. Attia, SL, Odhiambo, SA, Mogaka, JN, Ondondo, R, Schadler, A, McQuerry, K, et al.. Impact of maternal M. oleifera leaf supplementation on milk and serum vitamin A and carotenoid concentrations in a cohort of breastfeeding Kenyan women and their infants. Nutrients 2024;16:3425. https://doi.org/10.3390/nu16193425.Search in Google Scholar PubMed PubMed Central

27. Ceci, R, Maldini, M, La Rosa, P, Sgrò, P, Sharma, G, Dimauro, I, et al.. Comparative metabolomic analysis of M. oleifera leaves of different geographical origins and their antioxidant effects on C2C12 myotubes. Int J Mol Sci 2024;25:8109. https://doi.org/10.3390/ijms25158109.Search in Google Scholar PubMed PubMed Central

28. Gautam, N, Faroda, P, Gupta, AK. Artificial gynogenic apomixis of Moringa concanensis Nimmo.(wild drumstick): a fate map for haploid regeneration. Ind Crop Prod 2025;225:120537. https://doi.org/10.1016/j.indcrop.2025.120537.Search in Google Scholar

29. Rouf, ZA, Hussain, K, Nawaz, K, Fatima, N, Arshad, N, Iqbal, I, et al.. Comparative effectiveness of Moringa leaf extract, a natural biostimulant, with inorganic NPK fertilizer for regulating growth and the activities of enzymatic antioxidants in wheat (Triticum aestivum L.) Int J Appl Exp Biol 2025;4:73–80.10.56612/ijaaeb.v1i1.122Search in Google Scholar

30. Hridoy, MAAM, Munny, FJ, Shahriar, F, Rahman, MM, Islam, MF, Kazmi, A, et al.. Exploring the potentials of Sajana (M. oleifera Lam.) as a plant‐based feed ingredient to sustainable and good aquaculture practices: an analysis of growth performance and health benefits. Aquac Res 2025;2025:3580123. https://doi.org/10.1155/are/3580123.Search in Google Scholar

31. Siddik, MA, Julien, BB, Islam, SM, Francis, DS. Fermentation in aquafeed processing: achieving sustainability in feeds for global aquaculture production. Rev Aquacult 2024;16:1244–65. https://doi.org/10.1111/raq.12894.Search in Google Scholar

32. Ashraf, A, Sabu, S, Sasidharan, A, Sunooj, KV. Natural feed supplements from crustacean processing side streams for improved growth of finfishes and crustaceans: a review. J Anim Physiol Anim Nutr 2024:1–10. https://doi.org/10.1111/jpn.14058.Search in Google Scholar PubMed

33. Kurniasih, T, Zulkarnain, R, Wijaya, R, Lesmana, D, Mumpuni, FS, Panigoro, N, et al.. Digestibility of plant-based feeds in omnivorous, carnivorous, and herbivorous fish: a review of Nile tilapia (Oreochromis niloticus (Linnaeus, 1758)), North African catfish (Clarias gariepinus (Burchell, 1822)), and grass carp (Ctenopharyngodon idella (Valenciennes, 1844)). Aquacult Aquarium Conserv Legis 2024;17:2994–3014.Search in Google Scholar

34. Hao, PM, Quoc, LPT, Thu, PNM, Dao, NTT, Vy, LB. A comprehensive review of M. oleifera Lam.: a valuable plant in food and medicine. Int J Agric Technol 2024;20:1899–916.Search in Google Scholar

35. Hossain, MM, Rahman, MH, Tina, FW, Shahjahan, M. Present scenario and prospects of the use of aquatic plants in aquaculture: a review. Aquac Int 2024;32:6791–825. https://doi.org/10.1007/s10499-024-01489-1.Search in Google Scholar

36. Vijayanchali, SS. The role of M. oleifera pods, seeds, bark and root as functional food. World J Adv Res Rev 2024;21:1937–42. https://doi.org/10.30574/wjarr.2024.21.3.0933.Search in Google Scholar

37. Jegede, RE, Ayeni, G, Abaniwo, RM, Audu, GA, Haruna, A. Biochemical and phytochemical efficacy of defatted M. oleifera seeds in alleviating protein-energy malnutrition. bioRxiv 2024;2024–10.10.1101/2024.10.14.618128Search in Google Scholar

38. Matías, J, Rodríguez, MJ, Carrillo-Vico, A, Casals, J, Fondevilla, S, Haros, CM, et al.. From ‘farm to fork’: exploring the potential of nutrient-rich and stress-resilient emergent crops for sustainable and healthy food in the Mediterranean region in the face of climate change challenges. Plants 2024;13:1914. https://doi.org/10.3390/plants13141914.Search in Google Scholar PubMed PubMed Central

39. Klimek-Szczykutowicz, M, Gaweł-Bęben, K, Rutka, A, Blicharska, E, Tatarczak-Michalewska, M, Kulik-Siarek, K, et al.. M. oleifera (drumstick tree)—nutraceutical, cosmetological and medicinal importance: a review. Front Pharmacol 2024;15:1288382. https://doi.org/10.3389/fphar.2024.1288382.Search in Google Scholar PubMed PubMed Central

40. Musa, J, Njidda, AA. Chemical composition, anti-nutritive substances, amino acid profile and mineral composition of M. oleifera seeds subjected to different boiling duration. Niger J Anim Sci Technol (NJAST) 2021;4:43–52.Search in Google Scholar

41. Akib, MG, Rifat, A, Bormon, C, Dutta, A, Ataher, MS, Azzam, M, et al.. Effects of M. oleifera leaf powder on the growth performance, meat quality, blood parameters, and Cecal bacteria of Broilers. Vet Sci 2024;11:374. https://doi.org/10.3390/vetsci11080374.Search in Google Scholar PubMed PubMed Central

42. Garg, P, Pundir, S, Ali, A, Panja, S, Chellappan, DK, Dua, K, et al.. Exploring the potential of M. oleifera Lam in skin disorders and cosmetics: nutritional analysis, phytochemistry, geographical distribution, ethnomedicinal uses, dermatological studies and cosmetic formulations. N Schmied Arch Pharmacol 2024;397:3635–62. https://doi.org/10.1007/s00210-023-02862-2.Search in Google Scholar PubMed

43. Brar, S, Haugh, C, Robertson, N, Owuor, PM, Waterman, C, Fuchs III, GJ, et al.. The impact of M. oleifera leaf supplementation on human and animal nutrition, growth, and milk production: a systematic review. Phytother Res 2022;36:1600–15. https://doi.org/10.1002/ptr.7415.Search in Google Scholar PubMed

44. Kekana, TW, Marume, U, Nherera-Chokuda, FV. Prepartum supplementation of M. oleifera leaf meal: effects on health of the dam, colostrum quality, and acquisition of immunity in the calf. J Dairy Sci 2022;105:5813–21. https://doi.org/10.3168/jds.2021-21535.Search in Google Scholar PubMed

45. Al Masruri Haitham, AZR, Al Mufarji, A, Mohammed, AA, Al Madani, A, Mohammed, H. Leverage of M. oleifera supplementation on performances, biochemical, and milk profiles in mammals. Adv Anim Vet Sci 2022;10:2043–50. https://doi.org/10.17582/journal.aavs/2022/10.9.2043.2050.Search in Google Scholar

46. Islam, Z, Islam, SR, Hossen, F, Mahtab-ul-Islam, K, Hasan, MR, Karim, R. M. oleifera is a prominent source of nutrients with potential health benefits. Int J Food Sci 2021;2021:6627265. https://doi.org/10.1155/2021/6627265.Search in Google Scholar PubMed PubMed Central

47. Stevens, CG, Ugese, FD, Baiyeri, PK. Variations in mineral and vitamin content of M. oleifera provenances across Nigeria. For Trees Livelihoods 2021;30:106–15. https://doi.org/10.1080/14728028.2021.1878061.Search in Google Scholar

48. Louisa, M, Patintingan, CGH, Wardhani, BW. M. oleifera Lam. in cardiometabolic disorders: a systematic review of recent studies and possible mechanism of actions. Front Pharmacol 2022;13:792794. https://doi.org/10.3389/fphar.2022.792794.Search in Google Scholar PubMed PubMed Central

49. Mthiyane, FT, Dludla, PV, Ziqubu, K, Mthembu, SX, Muvhulawa, N, Hlengwa, N, et al.. A review on the antidiabetic properties of M. oleifera extracts: focusing on oxidative stress and inflammation as main therapeutic targets. Front Pharmacol 2022;13:940572. https://doi.org/10.3389/fphar.2022.940572.Search in Google Scholar PubMed PubMed Central

50. Chhikara, N, Kaur, A, Mann, S, Garg, MK, Sofi, SA, Panghal, A. Bioactive compounds, associated health benefits and safety considerations of M. oleifera L.: an updated review. Nutr Food Sci 2021;51:255–77. https://doi.org/10.1108/nfs-03-2020-0087.Search in Google Scholar

51. Ashaolu, TJ, Adeyeye, SA. African functional foods and beverages: a review. J Culin Sci Technol 2024;22:142–77. https://doi.org/10.1080/15428052.2022.2034697.Search in Google Scholar

52. Lombardo, M, Johnston, C. Abstracts of the 4th international electronic conference on nutrients (IECN 2024), 16–18 october 2024. Biol Life Sci Forum 2024;38:2. https://doi.org/10.3390/blsf2024038002.Search in Google Scholar

53. Rotella, R, Soriano, JM, Llopis-González, A, Morales-Suarez-Varela, M. The Impact of M. oleifera supplementation on anemia and other variables during pregnancy and breastfeeding: a narrative review. Nutrients 2023;15:2674.10.3390/nu15122674Search in Google Scholar PubMed PubMed Central

54. Sokhela, H, Govender, L, Siwela, M. Complementary feeding practices and childhood malnutrition in South Africa: the potential of M. oleifera leaf powder as a fortificant: a narrative review. Nutrients 2023;15:2011. https://doi.org/10.3390/nu15082011.Search in Google Scholar PubMed PubMed Central

55. Irfan, HM, Khan, NAK, Asmawi, MZ. M. oleifera Lam. leaf extracts reverse metabolic syndrome in Sprague Dawley rats fed high-fructose high fat diet for 60-days. Arch Physiol Biochem 2022;128:1202–8. https://doi.org/10.1080/13813455.2020.1762661.Search in Google Scholar PubMed

56. Baesso Moura, B, Hoshika, Y, Brunetti, C, dos Santos Nascimento, LB, Marra, E, Paoletti, E, et al.. Stress physiology of M. oleifera under tropospheric ozone enrichment: an ecotype‐specific investigation into growth, nonstructural carbohydrates, and polyphenols. Plant J 2024;120:2127–37. https://doi.org/10.1111/tpj.17107.Search in Google Scholar PubMed

57. Horn, L, Shakela, N, Mutorwa, MK, Naomab, E, Kwaambwa, HM. M. oleifera as a sustainable climate-smart solution to nutrition, disease prevention, and water treatment challenges: a review. J Agric Food Res 2022;10:100397. https://doi.org/10.1016/j.jafr.2022.100397.Search in Google Scholar

58. Mahaveerchand, H, Abdul Salam, AA. Environmental, industrial, and health benefits of M. oleifera. Phytochem Rev 2024:1–60.10.1007/s11101-024-09927-xSearch in Google Scholar

59. Oluwole, O, Ibidapo, O, Arowosola, T, Raji, F, Zandonadi, RP, Alasqah, I, et al.. Sustainable transformation agenda for enhanced global food and nutrition security: a narrative review. Front Nutr 2023;10:1226538. https://doi.org/10.3389/fnut.2023.1226538.Search in Google Scholar PubMed PubMed Central

60. Rosero, A, Granda, L, Berdugo-Cely, JA, Šamajová, O, Šamaj, J, Cerkal, R. A dual strategy of breeding for drought tolerance and introducing drought-tolerant, underutilized crops into production systems to enhance their resilience to water deficiency. Plants 2020;9:1263. https://doi.org/10.3390/plants9101263.Search in Google Scholar PubMed PubMed Central

61. Kumar, S, Saini, R, Suthar, P, Kumar, V, Sharma, R. Plant secondary metabolites: their food and therapeutic importance. In: Plant secondary metabolites: physico-chemical properties and therapeutic applications. Singapore: Springer Nature Singapore; 2022:371–413 pp.10.1007/978-981-16-4779-6_12Search in Google Scholar

62. Teclegeorgish, ZW, Aphane, YM, Mokgalaka, NS, Steenkamp, P, Tembu, VJ. Nutrients, secondary metabolites and anti-oxidant activity of M. oleifera leaves and Moringa-based commercial products. South Afr J Bot 2021;142:409–20. https://doi.org/10.1016/j.sajb.2021.07.008.Search in Google Scholar

63. Gafer, J, Hassan, GHAER, Ghoneim, HA, Mahmoud, MF. Amelioration of reproductive and productive performance in animal and poultry by M. oleifera free or nano-encapsulated. Eur J Vet Med 2023;3:11–8.10.24018/ejvetmed.2023.3.5.83Search in Google Scholar

64. Abdoun, K, Alsagan, A, Altahir, O, Suliman, G, Al-Haidary, A, Alsaiady, M. Cultivation and uses of M. oleifera as non-conventional feed stuff in livestock production: a review. Life 2022;13:63. https://doi.org/10.3390/life13010063.Search in Google Scholar PubMed PubMed Central

65. Khan, RU, Khan, A, Naz, S, Ullah, Q, Laudadio, V, Tufarelli, V, et al.. Potential applications of M. oleifera in poultry health and production as alternative to antibiotics: a review. Antibiotics 2021;10:1540. https://doi.org/10.3390/antibiotics10121540.Search in Google Scholar PubMed PubMed Central

66. Niju, S, Aishwarya, K, Balajii, M, Asaithambi, P. Statistical optimization of ultrasound‐assisted biodiesel production from M. oleifera oil–waste cooking oil mixture using modified conch shell catalyst. Environ Prog Sustain Energy 2024;43:e14243. https://doi.org/10.1002/ep.14243.Search in Google Scholar

67. Dzuvor, CK, Pan, S, Amanze, C, Amuzu, P, Asakiya, C, Kubi, F. Bioactive components from M. oleifera seeds: production, functionalities and applications–a critical review. Crit Rev Biotechnol 2022;42:271–93. https://doi.org/10.1080/07388551.2021.1931804.Search in Google Scholar PubMed

68. Jikah, AN, Edo, GI. M. oleifera: its industrial and pharmaceutical applications. A review. Vegetos 2024;37:1679–89. https://doi.org/10.1007/s42535-024-00866-8.Search in Google Scholar

69. Al-Jadabi, N, Laaouan, M, El Hajjaji, S, Mabrouki, J, Benbouzid, M, Dhiba, D. The dual performance of M. oleifera seeds as eco-friendly natural coagulant and as an antimicrobial for wastewater treatment: a review. Sustainability 2023;15:4280. https://doi.org/10.3390/su15054280.Search in Google Scholar

70. Maheshwari, S, Bharti, S, Gusain, A, Khan, SA, Matra, NG. FT-IR analysis of M. oleifera L. leaf extract and its insecticidal activity against Callosobruchus chinensis L.(Coleoptera: Bruchidae). Biol Forum – Int J 2023;15:1047–51.Search in Google Scholar

71. Praveen Joshi, SS, Sumathi, E, Murugan, M, Haran, R, Priya, SS, Shandeep, G, et al.. Exploration of bioactive molecules from Sesbania grandiflora (L.): identification of squalene as an effective compound against the two-spotted spider mite, Tetranychus urticae Koch, through molecular docking. Exp Appl Acarol 2025;94:22. https://doi.org/10.1007/s10493-024-00991-8.Search in Google Scholar PubMed

72. Landázuri, AC, Villarreal, JS, Nunez, ER, Pico, MM, Lagos, AS, Caviedes, M, et al.. Experimental evaluation of crushed M. oleifera Lam. seeds and powder waste during coagulation-flocculation processes. J Environ Chem Eng 2018;6:5443–51. https://doi.org/10.1016/j.jece.2018.08.021.Search in Google Scholar

73. Khursheed, A, Rather, MA, Jain, V, Rasool, S, Nazir, R, Malik, NA, et al.. Plant based natural products as potential ecofriendly and safer biopesticides: a comprehensive overview of their advantages over conventional pesticides, limitations and regulatory aspects. Microb Pathog 2022;173:105854. https://doi.org/10.1016/j.micpath.2022.105854.Search in Google Scholar PubMed

74. Nimnoi, P, Pongsilp, N. Potential health benefits of combined extracts from germinated brown jasmine rice (Oryza sativa L.), M. oleifera leaves, and Cordyceps militaris. CyTA-J Food 2024;22:1–11. https://doi.org/10.1080/19476337.2023.2297545.Search in Google Scholar

75. Dhandapani, S, Pakkirisamy, M, Rajaraman, R, Garratt, MP, Potts, SG, Raj, R, et al.. Floral interventions enhance flower visitor communities and pollination services in Moringa plantations. J Appl Ecol 2024;61:90–102. https://doi.org/10.1111/1365-2664.14532.Search in Google Scholar

76. Carvalho, DN, Calixto, ES, Del-Claro, K. Effects of vegetation on bird communities and bird–plant interactions in urban green areas of Riparian forests in Brazil that have undergone ecological restoration. Diversity 2025;17:149. https://doi.org/10.3390/d17030149.Search in Google Scholar

77. Beyki, MS, Mashhadi, E, Rashidi, J, Khavar, AHC, Safaei-Ghomi, J. Nature-inspired chemical methods. In: Green biomaterials in tissue engineering. American Chemical Society; 2025:1–53 pp.10.1021/bk-2025-1497.ch001Search in Google Scholar

78. El Bilali, H, Dan Guimbo, I, Nanema, RK, Falalou, H, Kiebre, Z, Rokka, VM, et al.. Research on Moringa (M. oleifera Lam.) in Africa. Plants 2024;13:1613. https://doi.org/10.3390/plants13121613.Search in Google Scholar PubMed PubMed Central

79. Gutierrez Herrera, JC, Martínez Ovallos, CA, Agudelo-Castañeda, DM, Paternina-Arboleda, CD. Exploring M. oleifera: green solutions for sustainable wastewater treatment and agricultural advancement. Sustainability 2024;16:9433.10.3390/su16219433Search in Google Scholar

80. Ghada, BK, Marwa, R, Shah, TA, Dabiellil, M, Dawoud, TM, Bourhia, M, et al.. Phytochemical composition, antioxidant potential, and insecticidal activity of M. oleifera extracts against tribolium castaneum: a sustainable approach to pest management. BMC Plant Biol 2025;25:579.10.1186/s12870-025-06626-3Search in Google Scholar PubMed PubMed Central

81. Shilaluke, KC, Moteetee, AN. Medicinal plants used traditionally as insecticides and antifeedants in sub-saharan Africa: a review. Biopestic Int 2019;15:1–9.Search in Google Scholar

82. Ruiz-Hernandez, R, Hernandez-Rodriguez, M, Cruz-Monterrosa, RG, Diaz-Ramirez, M, Martinez-Garcia, CG, Garcia-Martinez, A, et al.. M. oleifera Lam.: a review of environmental and management factors that influence the nutritional content of leaves. Trop Subtrop Agroecosyst 2022;25:1–10. https://doi.org/10.56369/tsaes.4053.Search in Google Scholar

83. Álvarez-Román, R, Silva-Flores, PG, Galindo-Rodríguez, SA, Huerta-Heredia, AA, Vilegas, W, Paniagua-Vega, D. Moisturizing and antioxidant evaluation of M. oleifera leaf extract in topical formulations by biophysical techniques. South Afr J Bot 2020;129:404–11. https://doi.org/10.1016/j.sajb.2019.10.011.Search in Google Scholar

84. Ngegba, PM, Cui, G, Khalid, MZ, Zhong, G. Use of botanical pesticides in agriculture as an alternative to synthetic pesticides. Agriculture 2022;12:600. https://doi.org/10.3390/agriculture12050600.Search in Google Scholar

85. Okwute, SK. Plants as potential sources of pesticidal agents. In: Pesticides: advances in chemical and botanical pesticides; 2012:207–320 pp.Search in Google Scholar

86. da Silva, ABSA, Caetano, RL, Carriço, C, Dos Santos, MM, Barbosa, JV, Dos Santos, JAA, et al.. Susceptibility of the blowfly, Chrysomya putoria (Diptera: Calliphoridae) to the ethanolic extracts of the medicinal plant M. oleifera (Magnoliopsida: Moringaceae). Rev Colomb Entomol 2024;50:1–8.10.25100/socolen.v50i2.12558Search in Google Scholar

87. Dagar, P, Ramakrishna, W. Plant based and synthetic products as mosquito repellents: effects, target sites and their mechanism of action on mosquitoes. Int J Trop Insect Sci 2024;44:1509–30. https://doi.org/10.1007/s42690-024-01329-y.Search in Google Scholar

88. Opoku-Bamfoh, O, Kwarteng, SA, Owusu, FA, Akpanya, R, Mensah, KA, Badu, M, et al.. Repellent and larvicidal properties of selected indigenous plants in the control of Anopheles mosquitoes. J Vector Borne Dis 2024;61:90–100. https://doi.org/10.4103/0972-9062.392267.Search in Google Scholar PubMed

89. Bello, OM, Abiodun, OB, Oguntoye, SO. Insight into the ethnopharmacology, phytochemistry, pharmacology of Launaea taraxacifolia (Willd) amin ex c. jeffrey as an underutilized vegetable from Nigeria: a review. Ann Univ Dunarea Jos Galati, Fasc VI Food Technol 2018;42:137–52.Search in Google Scholar

90. Clervil, E, Duchemin, JB, Amusant, N, Wozniak, E, Azam, D, Coke, M, et al.. Efficacy and selectivity of Sextonia rubra wood extracts and formulation in the control of Aedes aegypti strains. J Pest Sci 2024;97:2157–73. https://doi.org/10.1007/s10340-024-01747-4.Search in Google Scholar

91. Ati, VM, Meye, ED, Refli, AO, Amalo, D, Jebatu, UL. Moringa leaf (M. oleifera L) flavonoids utilization in suppressing growth of Aedes aegypti larvae Pemanfaatan Flavonoid Daun Kelor (M. oleifera L) dalam Menekan Pertumbuhan Larva Nyamuk Aedes aegypti. J Ilm Berkala Sains Terapan Kim 2022;16:1–10.10.20527/jstk.v16i1.12377Search in Google Scholar

92. de Medeiros, MLS, de Moura, MC, Napoleão, TH, Paiva, PMG, Coelho, LCBB, Bezerra, ACDS, et al.. Nematicidal activity of a water soluble lectin from seeds of M. oleifera. Int J Biol Macromol 2018;108:782–9. https://doi.org/10.1016/j.ijbiomac.2017.10.167.Search in Google Scholar PubMed

93. Santos, NDDL, Albuquerque, LPD, de Amorim, MMR, de Oliveira Silva, JN, Procópio, TF, Santos, PÉMD, et al.. Effects of lectin preparations from microgramma vacciniifolia rhizomes on the survival, digestive enzymes, and acetylcholinesterase activity of Alphitobius diaperinus (Panzer)(Coleoptera: Tenebrionidae). Macromolecules 2023;3:451–62. https://doi.org/10.3390/macromol3030027.Search in Google Scholar

94. Singh, R, Singh, G. Aphids. In: Polyphagous pests of crops; 2021:105–82 pp.10.1007/978-981-15-8075-8_3Search in Google Scholar

95. Taaban, SK. Study of the efficacy of Moringa leaf extract as an insecticide against white fly and aphids insects. Iraqi J Ind Res 2022;9:108–14. https://doi.org/10.53523/ijoirvol9i1id50.Search in Google Scholar

96. Ali, H, Ameer, S, Qasim, M, Fiaz, S, Ali, S, Zaheer, S, et al.. Efficacy of botanical plant extracts on the population dynamics of cotton aphid, Aphis gossypii glover (Hemiptera; Aphididae). J Bioresour Manag 2022;9:11.Search in Google Scholar

97. Shobana, N, Prakash, P, Samrot, AV, Jane Cypriyana, PJ, Kajal, P, Sathiyasree, M, et al.. Purification and characterization of gum-derived polysaccharides of M. oleifera and Azadirachta indica and their applications as plant stimulants and bio-pesticidal agents. Molecules 2022;27:3720. https://doi.org/10.3390/molecules27123720.Search in Google Scholar PubMed PubMed Central

98. Valdés-Rodríguez, OA. Metabolites in M. oleifera and their associated health potentials. Stud Nat Prod Chem 2023;76:299–330.10.1016/B978-0-323-91296-9.00003-4Search in Google Scholar

99. Osman, A, Elsobki, AEAM. Insecticidal activity and chemical composition of M. oleifera extract against the leguminous aphid, Aphis craccivora Koch on broad bean plants. J Plant Prot Pathol 2019;10:567–71.10.21608/jppp.2019.77958Search in Google Scholar

100. Abo El-Fadl, S, Osman, A, Al-Zohairy, AM, Dahab, AA, Abo El Kheir, ZA. Assessment of total phenolic, flavonoid content, antioxidant potential and hplc profile of three Moringa species leaf extracts. Sci J Flowers Ornam Plants 2020;7:53–70. https://doi.org/10.21608/sjfop.2020.91397.Search in Google Scholar

101. Rizk, SA, Sayed, RM. Protection of cowpea seeds from Callosobruchus maculatus infestation by using irradiated Moringa olifera Leaves1. Entomol News 2024;131:158–67. https://doi.org/10.3157/021.131.0304.Search in Google Scholar

102. Flores-Cortez, HG, Heinz-Castro, RTQ, Segura-Martínez, MTDJ, Chacón-Hernández, JC, Delgado-Martínez, R, Hernández-Juárez, A. Ovicidal effect of the ethanolic extract of M. oleifera leaf on Oligonychus punicae (Trombidiformes: Tetranychidae) Eggs1. J Entomol Sci 2025;60:59–71. https://doi.org/10.18474/jes23-108.Search in Google Scholar

103. Amjad, SF, Lalarukh, I, Danish, S, Mansoora, N, Alharbi, NK, Alharbi, MA, et al.. Interactive potential effects of Moringa leaf extracts and plant growth promoting Rhizobacteria against aphid attack on A newly developed wheat variety. Pakistan J Bot 2023;55:111–18. https://doi.org/10.30848/pjb2023-si(13).Search in Google Scholar

104. Arshad, N, Iqbal, MS. Improving morphological and biochemical characters, yield attributes and aphid mortality in wheat (Triticum aestivum L.) by biostimulants. Appl Ecol Environ Res 2022;20:1–5. https://doi.org/10.15666/aeer/2006_51035123.Search in Google Scholar

105. Beyari, EA. Alternatives to chemical pesticides: the role of microbial biocontrol agents in phytopathogen management: a comprehensive review. J Plant Pathol 2024:1–24. https://doi.org/10.1007/s42161-024-01808-8.Search in Google Scholar

106. Jampílek, J, Kráľová, K. Biopesticides for management of arthropod pests and weeds. In: Biopesticides. Woodhead Publishing; 2022:133–58 pp.10.1016/B978-0-12-823355-9.00009-2Search in Google Scholar

107. Olazaran-Santibañez, FE, Heinz-Castro, RT, Rivera, G, Rocandio-Rodríguez, M, Navarrete-Carriola, DV, Zapata-Campos, CC, et al.. Evaluation of ethanol extract of Magnolia alejandrae (Magnoliales: Magnoliaceae) against Tetranychus merganser (Acari: Tetranychidae). J Entomol Sci 2024;59:193–210. https://doi.org/10.18474/jes23-58.Search in Google Scholar

108. Chacón-Hernández, JC, Heinz-Castro, RT. Ovicidal and residual effects of M. oleifera leaf ethanol extract on Tetranychus merganser (Trombidiformes: Tetranychidae). J Plant Dis Prot 2023;130:519–28. https://doi.org/10.1007/s41348-023-00711-1.Search in Google Scholar

109. Heinz-Castro, RTQ, Arredondo-Valdés, R, Ordaz-Silva, S, Méndez-Cortés, H, Hernández-Juárez, A, Chacón-Hernández, JC. Bioacaricidal potential of M. oleifera ethanol extract for Tetranychus merganser Boudreaux (Acari: Tetranychidae) control. Plants 2021;10:1034.10.3390/plants10061034Search in Google Scholar PubMed PubMed Central

110. Kaur, M, Choudhary, A, Saraf, I, Singh, IP, Kaur, S. Efficacy of M. oleifera (Lam.) extract against Spodoptera litura (Fabricius), (Lepidoptera: Noctuidae). Int J Trop Insect Sci 2021:1–6.10.1007/s42690-021-00522-7Search in Google Scholar

111. Dangi, K, Verma, AK. Efficient & eco-friendly smart nano-pesticides: emerging prospects for agriculture. Mater Today Proc 2021;45:3819–24.10.1016/j.matpr.2021.03.211Search in Google Scholar

112. Costa, CA, Guiné, RP, Costa, DV, Correia, HE, Nave, A. Pest control in organic farming. In: In advances in resting-state functional MRI; 2023:111–79 pp.10.1016/B978-0-323-99145-2.00003-3Search in Google Scholar

113. Rocandio-Rodríguez, M, Torres-Castillo, JA, Juárez-Aragón, MC, Chacón-Hernández, JC, Moreno-Ramírez, YDR, Mora-Ravelo, SG, et al.. Evaluation of resistance of eleven maize races (Zea mays L.) to the red spider mite (Tetranychus merganser, Boudreaux). Plants 2022;11:1414. https://doi.org/10.3390/plants11111414.Search in Google Scholar PubMed PubMed Central

114. Amala, K, Karthi, S, Ganesan, R, Radhakrishnan, N, Srinivasan, K, Mostafa, AEZM, et al.. Bioefficacy of Epaltes divaricata (L.) n-Hexane extracts and their major metabolites against the Lepidopteran pests Spodoptera litura (fab.) and dengue mosquito Aedes aegypti (Linn.) Molecules 2021;26:3695. https://doi.org/10.3390/molecules26123695.Search in Google Scholar PubMed PubMed Central

115. Benjamin, J, Idowu, O, Babalola, OK, Oziegbe, EV, Oyedokun, DO, Akinyemi, AM, et al.. Cereal production in Africa: the threat of certain pests and weeds in a changing climate—a review. Agric Food Secur 2024;13:18. https://doi.org/10.1186/s40066-024-00470-8.Search in Google Scholar

116. Silva, JK, Veras, ACC, Sousa, SM, Albuquerque, JS, Ribeiro, FPB, Lima, NKS, et al.. The water extract and the lectin WSMoL from the seeds of M. oleifera prevent the hypertension onset by decreasing renal oxidative stress. An Acad Bras Ciências 2024;96:e20231266. https://doi.org/10.1590/0001-3765202420231266.Search in Google Scholar PubMed

117. Nta, AI, Agbo, BE, Etim, IF, Bassey, DA, Imalele, EE. Bioinsecticidal activities of Azadirachta Indica and M. oleifera against Maize Weevil (Sitophilus Zeamais) and rice Weevil (Sitophilus Oryzae)–a review. Global J Pure Appl Sci 2024;30:271–82. https://doi.org/10.4314/gjpas.v30i3.1.Search in Google Scholar

118. Divya, S, Pandey, VK, Dixit, R, Rustagi, S, Suthar, T, Atuahene, D, et al.. Exploring the phytochemical, pharmacological and nutritional properties of M. oleifera: a comprehensive review. Nutrients 2024;16:3423. https://doi.org/10.3390/nu16193423.Search in Google Scholar PubMed PubMed Central

119. Rahman, M, Khatun, A, Liu, L, Barkla, BJ. Brassicaceae mustards: phytochemical constituents, pharmacological effects, and mechanisms of action against human disease. Int J Mol Sci 2024;25:9039. https://doi.org/10.3390/ijms25169039.Search in Google Scholar PubMed PubMed Central

120. Khan, F, Yasmin, S, Pervez, M, Din, BU, Manzoor, F, Ullah, I. Comparison of biopesticides and synthetic insecticides against Citrus psylla (Diaphorina citri) in Citrus Orchad Rabbat District Dir lower. Jammu Kashmir J Agric 2024;4:199–205.Search in Google Scholar

121. Seimandi, GM, Imhoff, SDC, Derita, MG. Bioactivity of raphanus species against agricultural phytopathogens and its role in soil remediation: a review. Comb Chem High Throughput Screen 2024;27:516–44. https://doi.org/10.2174/1386207326666230706123818.Search in Google Scholar PubMed

122. Agrawal, H, Joshi, R, Gupta, M. Nutrients and secondary metabolites analysis of horticulture crops. In: Advances in postharvest and analytical technology of horticulture crops. Singapore: Springer Nature; 2024:183–207 pp.10.1007/978-981-97-7247-6_10Search in Google Scholar

123. Pal, D, Takeshwar, Thakur, S. M. oleifera and its secondary metabolites: chemistry, properties and antidiabetic potentiality. Nat Prod J 2024;14:15–32. https://doi.org/10.2174/0122103155279969231123022102.Search in Google Scholar

124. Lin, DJ, Fang, Y, Li, LY, Zhang, LZ, Gao, SJ, Wang, R, et al.. The insecticidal effect of the botanical insecticide chlorogenic acid on Mythimna separata (Walker) is related to changes in MsCYP450 gene expression. Front Plant Sci 2022;13:1015095. https://doi.org/10.3389/fpls.2022.1015095.Search in Google Scholar PubMed PubMed Central

125. Pratyusha, S. Phenolic compounds in the plant development and defense. Plant Stress Physiol: Perspect Agric 2022:125.10.5772/intechopen.102873Search in Google Scholar

126. Ruttarattanamongkol, K, Siebenhandl-Ehn, S, Schreiner, M, Petrasch, AM. Pilot-scale supercritical carbon dioxide extraction, physico-chemical properties and profile characterization of M. oleifera seed oil in comparison with conventional extraction methods. Ind Crop Prod 2014;58:68–77. https://doi.org/10.1016/j.indcrop.2014.03.020.Search in Google Scholar

127. Han, M, Kasim, S, Yang, Z, Deng, X, Saidi, NB, Uddin, MK, et al.. Plant extracts as biostimulant agents: a promising strategy for managing environmental stress in sustainable agriculture. Phyton 2024;93:0031–9457. https://doi.org/10.32604/phyton.2024.054009.Search in Google Scholar

128. Wu, L, Li, L, Chen, S, Wang, L, Lin, X. Deep eutectic solvent-based ultrasonic-assisted extraction of phenolic compounds from M. oleifera L. leaves: optimization, comparison and antioxidant activity. Sep Purif Technol 2020;247:117014. https://doi.org/10.1016/j.seppur.2020.117014.Search in Google Scholar

129. Cakaloglu, B, Ozyurt, VH, Otles, S. Cold press in oil extraction. A review. Ukr Food J 2018;7:640–54. https://doi.org/10.24263/2304-974x-2018-7-4-9.Search in Google Scholar

130. Zia, S, Khan, MR, Shabbir, MA, Aslam Maan, A, Khan, MKI, Nadeem, M, et al.. An inclusive overview of advanced thermal and nonthermal extraction techniques for bioactive compounds in food and food-related matrices. Food Rev Int 2022;38:1166–96. https://doi.org/10.1080/87559129.2020.1772283.Search in Google Scholar

131. Rocchetti, G, Blasi, F, Montesano, D, Ghisoni, S, Marcotullio, MC, Sabatini, S, et al.. Impact of conventional/non-conventional extraction methods on the untargeted phenolic profile of M. oleifera leaves. Food Res Int 2019;115:319–27. https://doi.org/10.1016/j.foodres.2018.11.046.Search in Google Scholar PubMed

132. Tariq, I, Yasmin, A, Imran, A, Akhtar, H, Afzaal, M, Azeem, M, et al.. A review on extraction technique and immune-boosting properties of M. oleifera Lam. Int J Food Prop 2023;26:2493–508. https://doi.org/10.1080/10942912.2023.2249263.Search in Google Scholar

133. Nebolisa, NM, Umeyor, CE, Ekpunobi, UE, Umeyor, IC, Okoye, FB. Profiling the effects of microwave-assisted and soxhlet extraction techniques on the physicochemical attributes of M. oleifera seed oil and proteins. Oil Crop Sci 2023;8:16–26. https://doi.org/10.1016/j.ocsci.2023.02.003.Search in Google Scholar

134. Sharma, P, Wichaphon, J, Klangpetch, W. Antimicrobial and antioxidant activities of defatted M. oleifera seed meal extract obtained by ultrasound-assisted extraction and application as a natural antimicrobial coating for raw chicken sausages. Int J Food Microbiol 2020;332:108770. https://doi.org/10.1016/j.ijfoodmicro.2020.108770.Search in Google Scholar PubMed

135. Souza, DES, Melo, JJCD, Santos, FFD, Vasconcelos, ALDS, Jesus, ADSD, Freitas, LDS, et al.. Microwave-assisted vs. Conventional extraction of M. oleifera seed oil: process optimization and efficiency comparison. Foods 2024;13:3141. https://doi.org/10.3390/foods13193141.Search in Google Scholar PubMed PubMed Central

136. Kessler, JC, Martins, IM, Manrique, YA, Rodrigues, AE, Barreiro, MF, Dias, MM. Advancements in conventional and supercritical CO2 extraction of M. oleifera bioactives for cosmetic applications: a review. J Supercrit Fluids 2024:106388. https://doi.org/10.1016/j.supflu.2024.106388.Search in Google Scholar

137. Kleekayai, T, Khalesi, M, Amigo-Benavent, M, Cermeño, M, Harnedy-Rothwell, P, FitzGerald, RJ. Enzyme-assisted extraction of plant proteins. In: Green protein processing technologies from plants: novel extraction and purification methods for product development. Cham: Springer International Publishing; 2023:131–78 pp.10.1007/978-3-031-16968-7_6Search in Google Scholar

138. Shrivastav, G, Prava Jyoti, T, Chandel, S, Singh, R. Eco-friendly extraction: innovations, principles, and comparison with traditional methods. Separ Purif Rev 2024:1–17. https://doi.org/10.1080/15422119.2024.2381605.Search in Google Scholar

139. Tridiptasari, A, Leksono, AS, Siswanto, D. Antifeedant effect of M. oleifera (L.) leaf and seed extract on growth and feeding activity of Spodoptera litura (Fab.)(Lepidoptera: Noctuidae). J Exp Life Sci 2019;9:25–31. https://doi.org/10.21776/ub.jels.2019.009.01.05.Search in Google Scholar

140. Kortbeek, RW, van der Gragt, M, Bleeker, PM. Endogenous plant metabolites against insects. Eur J Plant Pathol 2019;154:67–90. https://doi.org/10.1007/s10658-018-1540-6.Search in Google Scholar

141. Qasim, M, Islam, W, Ashraf, HJ, Ali, I, Wang, L. Saponins in insect pest control. Co-evol Second Metab 2020:897–924. https://doi.org/10.1007/978-3-319-96397-6_39.Search in Google Scholar

142. Abd El-Hack, ME, Alagawany, M, Elrys, AS, Desoky, ESM, Tolba, HM, Elnahal, AS, et al.. Effect of forage M. oleifera L.(Moringa) on animal health and nutrition and its beneficial applications in soil, plants and water purification. Agriculture 2018;8:145.10.3390/agriculture8090145Search in Google Scholar

143. Mandokhail, YK, Maalik, A, Hashmi, MZ, Farooq, U, Nawaz, M, Rehman, ZU, et al.. Endocrine-disrupting compounds. In: Environmental micropollutants. Elsevier; 2022:183–99 pp.10.1016/B978-0-323-90555-8.00011-8Search in Google Scholar

144. Mohlala, K, Offor, U, Monageng, E, Takalani, NB, Opuwari, CS. Overview of the effects of M. oleifera leaf extract on oxidative stress and male infertility: a review. Appl Sci 2023;13:4387. https://doi.org/10.3390/app13074387.Search in Google Scholar

145. Tvrdá, E, Benko, F, Slanina, T, du Plessis, SS. The role of selected natural biomolecules in sperm production and functionality. Molecules 2021;26:5196. https://doi.org/10.3390/molecules26175196.Search in Google Scholar PubMed PubMed Central

146. Mangla, Y, Khanduri, P, Gupta, CK. Reproductive biology of angiosperms: concepts and laboratory methods. Cambridge: Cambridge University Press; 2023.10.1017/9781009160414Search in Google Scholar

147. Mehboob, A, Zaka, SM, Sarmad, M, Bajwa, M. Feeding and oviposition deterrence of murraya paniculata, piper nigrum and M. oleifera extracts against Spodoptera litura (F). Pakistan J Zool 2019;51:567. https://doi.org/10.17582/journal.pjz/2019.51.2.567.574.Search in Google Scholar

148. Elghandour, MMMY, Maggiolino, A, Vázquez-Mendoza, P, Alvarado-Ramírez, ER, Cedillo-Monroy, J, De Palo, P, et al.. M. oleifera as a natural alternative for the control of gastrointestinal parasites in equines: a review. Plants 2023;12:1921.10.3390/plants12091921Search in Google Scholar PubMed PubMed Central

149. Grubisic, M, van Grunsven, RH. Artificial light at night disrupts species interactions and changes insect communities. Curr Opin Insect Sci 2021;47:136–41. https://doi.org/10.1016/j.cois.2021.06.007.Search in Google Scholar PubMed

150. Kashyap, P, Kumar, S, Riar, CS, Jindal, N, Baniwal, P, Guiné, RP, et al.. Recent advances in Drumstick (M. oleifera) leaves bioactive compounds: composition, health benefits, bioaccessibility, and dietary applications. Antioxidants 2022;11:402. https://doi.org/10.3390/antiox11020402.Search in Google Scholar PubMed PubMed Central

151. Redha, AA, Perna, S, Riva, A, Petrangolini, G, Peroni, G, Nichetti, M, et al.. Novel insights on anti-obesity potential of the miracle tree, M. oleifera: a systematic review. J Funct Foods 2021;84:104600. https://doi.org/10.1016/j.jff.2021.104600.Search in Google Scholar

152. Chiş, A, Noubissi, PA, Pop, OL, Mureşan, CI, Fokam Tagne, MA, Kamgang, R, et al.. Bioactive compounds in M. oleifera: mechanisms of action, focus on their anti-inflammatory properties. Plants 2023;13:20. https://doi.org/10.3390/plants13010020.Search in Google Scholar PubMed PubMed Central

153. Keservani, RK, Tung, BT, Kesharwani, RK, Ahire, ED, editors. Plant metabolites and vegetables as nutraceuticals. CRC Press; 2024.10.1201/9781032680125Search in Google Scholar

154. Nwachukwu, I. Japa and other stories. University of Georgia Press; 2024, vol 122.10.1353/book.129100Search in Google Scholar

155. El-Sherbiny, GM, Alluqmani, AJ, Elsehemy, IA, Kalaba, MH. Antibacterial, antioxidant, cytotoxicity, and phytochemical screening of M. oleifera leaves. Sci Rep 2024;14:1–17.10.1038/s41598-024-80700-ySearch in Google Scholar PubMed PubMed Central

156. Jaglan, P, Kaushik, D, Kumar, M, Singh, J, Oz, F, Shubham, S, et al.. A critical review on M. oleifera: current status, physicochemical attributes, and food industrial applications. Nat Prod Res 2024:1–15.10.1080/14786419.2024.2387833Search in Google Scholar PubMed

157. Tawade, M, Chopade, J, Thomas, A. Ardisia solanacea (Poir.) Roxb.–an unexplored medicinal plant. Bull Environ, Pharmacol Life Sci 2024;5:168–78.Search in Google Scholar

158. Murti, Y, Arora, S, Akram, W, Bharadwaj, H, Gupta, K, Sachdev, A, et al.. Exploring the therapeutic potential of M. oleifera Lam. In traditional Chinese medicine: a comprehensive review. Pharmacol Res Mod Chin Med 2024:100473. https://doi.org/10.1016/j.prmcm.2024.100473.Search in Google Scholar

159. Masarkar, N, Ray, SK, Saleem, Z, Mukherjee, S. Potential anti-cancer activity of M. oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer. J Compl Integr Med 2024;21:282–94. https://doi.org/10.1515/jcim-2023-0182.Search in Google Scholar PubMed

160. Rajkumar, C, Ramsridhar, S, Veeraraghavan, VP, Francis, AP, Purushotham, M, Mageshwari, U. Anticancer effect of M. oleifera in oral squamous cell carcinoma: a systematic review. Discov Oncol 2024;15:1–11.10.1007/s12672-024-01557-1Search in Google Scholar PubMed PubMed Central

161. Rajabi, L, Ebrahimdoost, M, Mohammadi, SA, Soleimani Samarkhazan, H, Khamisipour, G, Aghaei, M. Aqueous and ethanolic extracts of M. oleifera leaves induce selective cytotoxicity in Raji and Jurkat cell lines by activating the P21 pathway independent of P53. Mol Biol Rep 2025;52:102. https://doi.org/10.1007/s11033-024-10200-9.Search in Google Scholar PubMed

162. Gurjar, VK, Pal, D. Role of Moringa seed and its secondary metabolites against cancer: chemistry, morphology, and mode of action. In: Seeds: anti-proliferative storehouse for bioactive secondary metabolites. Singapore: Springer Nature; 2024:643–79 pp.10.1007/978-981-97-3014-8_22Search in Google Scholar

163. Azlan, UK, Mediani, A, Rohani, ER, Tong, X, Han, R, Misnan, NM, et al.. A comprehensive review with updated future perspectives on the ethnomedicinal and pharmacological aspects of M. oleifera. Molecules 2022;27:5765. https://doi.org/10.3390/molecules27185765.Search in Google Scholar PubMed PubMed Central

164. Hassan, MA, Xu, T, Tian, Y, Zhong, Y, Ali, FAZ, Yang, X, et al.. Health benefits and phenolic compounds of M. oleifera leaves: a comprehensive review. Phytomedicine 2021;93:153771. https://doi.org/10.1016/j.phymed.2021.153771.Search in Google Scholar PubMed

165. Ramamurthy, S, Varghese, S, Sudarsan, S, Muruganandhan, J, Mushtaq, S, Patil, PB, et al.. M. oleifera: antioxidant, anticancer, anti-inflammatory, and related properties of extracts in cell lines: a review of medicinal effects, phytochemistry, and applications. J Contemp Dent Pract 2021;22:1483–92. https://doi.org/10.5005/jp-journals-10024-3187.Search in Google Scholar

166. Karimi, I. M. oleifera Lamarck (1785), Moringaceae and cancer I: a systematic and comprehensive review of 24 years of research. Asian Pac J Cancer Biol 2022;7:75–96. https://doi.org/10.31557/apjcb.2022.7.1.75-96.Search in Google Scholar

167. Moremane, MM, Abrahams, B, Tiloke, C. M. oleifera: a review on the antiproliferative potential in breast cancer cells. Curr Issues Mol Biol 2023;45:6880–902. https://doi.org/10.3390/cimb45080434.Search in Google Scholar PubMed PubMed Central

168. Kumar, S, Verma, PK, Shukla, A, Singh, RK, Patel, AK, Yadav, L, et al.. M. oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton’s Lymphoma: an in vitro and in vivo study. J Ethnopharmacol 2023;302:115849. https://doi.org/10.1016/j.jep.2022.115849.Search in Google Scholar PubMed

169. Srivastava, S, Pandey, VK, Dash, KK, Dayal, D, Wal, P, Debnath, B, et al.. Dynamic bioactive properties of nutritional superfood M. oleifera: a comprehensive review. J Agric Food Res 2023;14:100860. https://doi.org/10.1016/j.jafr.2023.100860.Search in Google Scholar

170. Olvera-Aguirre, G, Mendoza-Taco, MM, Moo-Huchin, VM, Lee-Rangel, HA, Roque-Jiménez, JA, Gómez-Vázquez, A, et al.. Effect of extraction type on bioactive compounds and antioxidant activity of M. oleifera Lam. leaves. Agriculture 2022;12:1462. https://doi.org/10.3390/agriculture12091462.Search in Google Scholar

171. Kurniawan, YS, Amrulloh, H, Apriani, I, Lestari, A, Erawanti, B, Saputri, A, et al.. A comparative study on phytochemical screening and antioxidant activity of aqueous extract from various parts of M. oleifera. Indones J Nat Pigm 2021;3:43–7. https://doi.org/10.33479/ijnp.2021.03.2.43.Search in Google Scholar

172. Nouioura, G, El Fadili, M, El Barnossi, A, Loukili, EH, Laaroussi, H, Bouhrim, M, et al.. Comprehensive analysis of different solvent extracts of Ferula communis L. fruit reveals phenolic compounds and their biological properties via in vitro and in silico assays. Sci Rep 2024;14:8325. https://doi.org/10.1038/s41598-024-59087-3.Search in Google Scholar PubMed PubMed Central

173. Eid, O, Ezzat, S, Elkady, WM, El Sayed, A, Abd el-sattar, E. Evaluation of antioxidant activity in different Egyptian barley cultivars: an in vitro and in silico study. Future J Pharm Sci 2024;10:69. https://doi.org/10.1186/s43094-024-00642-0.Search in Google Scholar

174. Younis, N, Khan, MI, Zahoor, T, Faisal, MN. Phytochemical and antioxidant screening of M. oleifera for its utilization in the management of hepatic injury. Front Nutr 2022;9:1078896. https://doi.org/10.3389/fnut.2022.1078896.Search in Google Scholar PubMed PubMed Central

175. Khan, S, Ullah, H, Hussain, R, Khan, MU, Khan, Y, Hussain, A, et al.. Design, synthesis, in vitro biological assessment and in silico molecular modeling study of thiazole-thiazolidinone derivatives as potent anti-cancer agents. Results Chem 2024;7:101507. https://doi.org/10.1016/j.rechem.2024.101507.Search in Google Scholar

176. Ercan, K, Gecesefa, OF, Taysi, ME, Ali Ali, OA, Taysi, S. M. oleifera: a review of its occurrence, pharmacological importance and oxidative stress. Mini Rev Med Chem 2021;21:380–96. https://doi.org/10.2174/1389557520999200728162453.Search in Google Scholar PubMed

177. Nisar, A, Jagtap, S, Vyavahare, S, Deshpande, M, Harsulkar, A, Ranjekar, P, et al.. Phytochemicals in the treatment of inflammation-associated diseases: the journey from preclinical trials to clinical practice. Front Pharmacol 2023;14:1177050. https://doi.org/10.3389/fphar.2023.1177050.Search in Google Scholar PubMed PubMed Central

178. Baqi, A, Samiullah, Khan, J, Sadiq, A, Khan, Y, Ali, S, et al.. Computational identification and experimental validation of novel Saccharum officinarum microRNAs along with their targets through RT-PCR approach. Plant Signal Behav 2025;20:2452334. https://doi.org/10.1080/15592324.2025.2452334.Search in Google Scholar PubMed PubMed Central

179. Naz, H, Othman, MS, Rahim, F, Hussain, R, Khan, S, Taha, M, et al.. Investigation of novel benzimidazole-based indole/thiazole hybrids derivatives as effective anti-diabetics and anti-alzheimer’s agents: structure-activity relationship insight, in vitro and in silico approaches. J Mol Struct 2024;1312:138592. https://doi.org/10.1016/j.molstruc.2024.138592.Search in Google Scholar

180. Hussain, R, Khan, S, Khan, Y, Iqbal, T, Anwar, S, Aziz, T, et al.. Development of promising acetylcholinesterase and butyrylcholinesterase inhibitors: synthesis, in vitro and in silico approaches of pyridine derived fused bis-oxadiazole and bis-thiadiazole derivatives. J Mol Struct 2024;1310:138228. https://doi.org/10.1016/j.molstruc.2024.138228.Search in Google Scholar

181. Khan, S, Hussain, R, Khan, Y, Iqbal, T, Chinnam, S, Akif, M, et al.. Hybrid benzothiazole derived fused triazole/thiazole derivatives as versatile anti-Alzheimer agents: synthesis, characterization, biological evaluation and molecular docking studies. J Mol Struct 2024;1318:139200. https://doi.org/10.1016/j.molstruc.2024.139200.Search in Google Scholar

182. Khan, S, Khan, Y, Al-Qaaneh, AM, Hussain, R, Iqbal, T, Ullah, H, et al.. Exploring effective diagnosis of Alzheimer disease: experimental and computational analysis of hybrid benzimidazole based thiazolidinone derivatives. Results Chem 2024;9:101663. https://doi.org/10.1016/j.rechem.2024.101663.Search in Google Scholar

183. Karthikeyan, G, Swamy, MK, Viknesh, MR, Shurya, R, Sudhakar, N. Bioactive Phytocompounds to fight against antimicrobial resistance. Plant-Deriv Bioact: Prod Prop Ther Appl 2020:335–81. https://doi.org/10.1007/978-981-15-1761-7_14.Search in Google Scholar

184. Rasheed, HA, Rehman, A, Karim, A, Al-Asmari, F, Cui, H, Lin, L. A comprehensive insight into plant-derived extracts/bioactives: exploring their antimicrobial mechanisms and potential for high-performance food applications. Food Biosci 2024:104035. https://doi.org/10.1016/j.fbio.2024.104035.Search in Google Scholar

185. Machina, FM. Antibacterial activity of M. oleifera methanolic leaves extracts against some Gram-positive and Gram-negative bacterial isolates. Microbes Infect Dis 2022;3:199–208.Search in Google Scholar

186. Biswas, D, Nandy, S, Mukherjee, A, Pandey, DK, Dey, A. M. oleifera Lam. and derived phytochemicals as promising antiviral agents: a review. South Afr J Bot 2020;129:272–82. https://doi.org/10.1016/j.sajb.2019.07.049.Search in Google Scholar

187. Priya, V, Abiramasundari, P, Devi, SG, Jeyanthi, GP. Antibacterial activity of the leaves, bark, seed and flesh of M. oleifera. Int J Pharmaceut Sci Res 2011;2:2045.Search in Google Scholar

188. Kansal, SK, Kumari, A. Potential of M. oleifera for the treatment of water and wastewater. Chem Rev 2014;114:4993–5010. https://doi.org/10.1021/cr400093w.Search in Google Scholar PubMed

189. Moyo, B, Masika, PJ, Muchenje, V. Antimicrobial activities of M. oleifera Lam leaf extracts. Afr J Biotechnol 2012;11:2797–802. https://doi.org/10.5897/ajb10.686.Search in Google Scholar

190. Nweke, F. Antifungal activity of petroluem ether extracts of M. oleifera leaves and stem bark against some plant pathogenic fungi. J Nat Sci Res 2015;5:1–5.Search in Google Scholar

191. Ahmadu, T, Ahmad, K, Ismail, SI, Rashed, O, Asib, N, Omar, D. Antifungal efficacy of M. oleifera leaf and seed extracts against Botrytis cinerea causing gray mold disease of tomato (Solanum lycopersicum L.) Braz J Biol 2020;81:1007–22. https://doi.org/10.1590/1519-6984.233173.Search in Google Scholar PubMed

192. Iqbal, H, Jahan, N, Ali, S, Shahzad, A, Iqbal, R. Formulation of M. oleifera nanobiopesticides and their evaluation against Tribolium castaneum and Rhyzopertha Dominica. J Plant Dis Prot 2024;131:133–42. https://doi.org/10.1007/s41348-023-00802-z.Search in Google Scholar

193. Soliman, YM, Mahmoud, AM, Hussein, MF, Helmy, TA, Ayyat, AM. Impact of silicon and endophytic fungi application for plant survival, biomass and chemical compositions of M. oleifera Lam. Under Salinity Stress Conditions. Assiut J Agric Sci 2022;53:65–77. https://doi.org/10.21608/ajas.2022.164423.1180.Search in Google Scholar

194. Jimoh, WA, Ayeloja, AA, Badmus, GO, Olateju, KO. Antibacterial and antifungal effect of Moringa (M. oleifera) seedmeal on marinated smoked African mud catfish (Clarias gariepinus). J Food Saf 2020;40:e12772. https://doi.org/10.1111/jfs.12772.Search in Google Scholar

195. Abhang, P, Satape, RA, Masurkar, S. Phytochemical screening, antioxidant, and antimicrobial activities of M. oleifera extracts. Zoology (Anim Sci) 2024;43:618–29.Search in Google Scholar

196. Giugliano, R, Ferraro, V, Chianese, A, Della Marca, R, Zannella, C, Galdiero, F, et al.. Antiviral properties of M. oleifera leaf extracts against respiratory viruses. Viruses 2024;16:1199. https://doi.org/10.3390/v16081199.Search in Google Scholar PubMed PubMed Central

197. Alkharpotly, AA, Abd-Elkader, DY, Salem, MZ, Hassan, HS. Growth, productivity and phytochemicals of Coriander in responses to foliar application of Acacia saligna fruit extract as a biostimulant under field conditions. Sci Rep 2024;14:2921. https://doi.org/10.1038/s41598-024-53378-5.Search in Google Scholar PubMed PubMed Central

198. Naz, A, Chowdhury, A, Pareek, S, Kumar, P, Poddar, NK. A critical review on the active anti-viral metabolites of bioprospecting traditionally used plant species from semi-arid regions of the subcontinent. J Compl Integr Med 2024;21:412–39. https://doi.org/10.1515/jcim-2024-0186.Search in Google Scholar PubMed

199. Wilbroda, W, Anthony, W, Elizabeth, KM, Michael, GM. Effect of M. oleifera supplementation on CD4+ and CD8+ T cell patterns and renal functions of HIV/AIDS patients receiving highly active antiretroviral drugs (HAART). J Complementary Altern Med Res 2024;25:69–77. https://doi.org/10.9734/jocamr/2024/v25i9572.Search in Google Scholar

200. Khedkar, DD. Plant products and essential oil therapy for treatment of new and emerging viruses. In: Fighting multidrug resistance with herbal extracts, essential oils and their components. Academic Press; 2025:391–419 pp.10.1016/B978-0-443-29044-2.00017-5Search in Google Scholar

201. Yousefi Rad, A, Rastegari, AA, Shahanipour, K, Monajemi, R. M. oleifera and its biochemical compounds: potential multi-targeted therapeutic agents against COVID-19 and associated cancer progression. Biochem Genet 2024:1–24.10.1007/s10528-024-10758-wSearch in Google Scholar PubMed

202. Masoumvand, M, Ramezani, E, Rahimi, VB, Askari, VR. Promising influences of M. oleifera in functional foods against metabolic syndrome: a comprehensive and mechanistic review. Endocr Metab Immune Disord, Drug Targets 2024;24:1355–70. https://doi.org/10.2174/0118715303269893231207071440.Search in Google Scholar PubMed

203. Balekundri, A, Ahire, ED, Keservani, RK. Plant metabolites and vegetables for diabetes prevention and treatment. In: Plant metabolites and vegetables as nutraceuticals. Apple Academic Press; 2024:333–60 pp.10.1201/9781032680125-15Search in Google Scholar

204. Zarina, Wani, AW, Rawat, M, Kaur, H, Das, S, Kaur, T, et al.. Medicinal utilization and nutritional properties of drumstick (M. oleifera)—a comprehensive review. Food Sci Nutr 2024;12:4546–68. https://doi.org/10.1002/fsn3.4139.Search in Google Scholar PubMed PubMed Central

205. Jiang, X, Tang, J, Gao, Z, Chen, C, Li, W, Peng, L, et al.. Exploring the protection on islet β-cells and hypoglycemic effect of M. oleifera stem based on network pharmacology and experimental validation. J Funct Foods 2024;122:106499. https://doi.org/10.1016/j.jff.2024.106499.Search in Google Scholar

206. Ranade, M, Mudgalkar, N. Randomized, controlled open-label, pilot study of efficacy and safety of Shigrupatra (M. oleifera Lam. Leaves) capsule as an add-on therapy to standard medication in dyslipidemias in rural South Indian tertiary care hospital. J Ayurveda 2024;18:23–7.Search in Google Scholar

207. Ganiyu, AI, Yusuf, AP, Muntari, A, Kabir, S, Abdulrahman, B, Nura, L, et al.. Synergistic effects of combined treatments with oral zinc sulfate and dietary M. oleifera leaf powder on body weight, blood glucose, and lipid profile in streptozotocin-induced diabetic rats. FUOYE J Pure Appl Sci (FJPAS) 2024;9:131–45.Search in Google Scholar

208. Zeeshan, A, Munir, M, Sadia, S. Unlocking the promise of the ″miracle tree: a review on therapeutic applications and phytochemistry of M. oleifera L. J Bioresour Manag 2024;11:18.Search in Google Scholar

209. Srivastava, SP, Upadhyay, P, Das, S, Tiwari, N, Mishra, S, Tripathi, SM. Managing diabetic complications with alternative therapeutic strategies. Curr Diabetes Rev 2024;20:110–9. https://doi.org/10.2174/1573399820666230907112430.Search in Google Scholar PubMed

210. Adarthaiya, S, Sehgal, A. M. oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—a narrative review based on in vivo and clinical studies. Phytother Res 2024;38:755–75. https://doi.org/10.1002/ptr.8079.Search in Google Scholar PubMed

211. Padayachee, B, Baijnath, HJSAJOB. An updated comprehensive review of the medicinal, phytochemical and pharmacological properties of M. oleifera. South Afr J Bot 2020;129:304–16. https://doi.org/10.1016/j.sajb.2019.08.021.Search in Google Scholar

212. Singh, AK, Rana, HK, Tshabalala, T, Kumar, R, Gupta, A, Ndhlala, AR, et al.. Phytochemical, nutraceutical and pharmacological attributes of a functional crop M. oleifera Lam: an overview. South Afr J Bot 2020;129:209–20. https://doi.org/10.1016/j.sajb.2019.06.017.Search in Google Scholar

213. Alia, F, Putri, M, Anggraeni, N, Syamsunarno, MRAA. The potency of M. oleifera Lam. as protective agent in cardiac damage and vascular dysfunction. Front Pharmacol 2022;12:724439. https://doi.org/10.3389/fphar.2021.724439.Search in Google Scholar PubMed PubMed Central

214. Shahbaz, M, Naeem, H, Batool, M, Imran, M, Hussain, M, Mujtaba, A, et al.. Antioxidant, anticancer, and anti‐inflammatory potential of Moringa seed and Moringa seed oil: a comprehensive approach. Food Sci Nutr 2024;12:6157–73. https://doi.org/10.1002/fsn3.4312.Search in Google Scholar PubMed PubMed Central