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Enzyme inhibitory assessment of the isolated constituents from Plantago holosteum Scop.

  • F. Tugce Guragac Dereli , Yasin Genc , Iclal Saracoglu and Esra Kupeli Akkol EMAIL logo
Published/Copyright: April 7, 2020
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Abstract

Plants of the Plantago genus are widely used in Turkish folk medicine especially for the treatment of wound, abscess, and inflammation. The aqueous extract and five phenylethanoid glycosides acteoside (1), arenarioside (2), echinacoside (3), isoacteoside (4), and leucosceptoside A (5) isolated from the aerial parts and roots of Plantago holosteum Scop. (Plantaginaceae) were tested for their possible inhibitory activity against hyaluronidase, elastase, and collagenase, related to wound pathogenesis. Even though the aqueous extract prepared from the aerial parts (36.26%) and roots (47.01%) and the isolated compounds acteoside (29.13%), echinacoside (28.73%), and isoacteoside (31.69%) exerted a notable inhibition, arenarioside and leucosceptoside A were found inactive in the hyaluronidase enzyme inhibition test. Similar results were obtained from the collagenase enzyme inhibition test. The aqueous extract prepared from the aerial parts (31.09%) and roots (35.17%), echinacoside (25.13%), and isoacteoside (23.85%) exerted a notable inhibition in this test. However, none of the extracts and isolated compounds displayed elastase enzyme inhibitory activity. The experimental data demonstrated that P. holosteum displayed a remarkable enzyme inhibitory activity against hyaluronidase and collagenase. This paper is the first report regarding the in vitro enzyme inhibitory activity of P. holosteum.

  1. Conflict of interest: The authors declare that there are no conflicts of interest.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2020-0008).


Received: 2020-01-16
Revised: 2020-02-12
Accepted: 2020-02-12
Published Online: 2020-04-07
Published in Print: 2020-03-26

©2020 Walter de Gruyter GmbH, Berlin/Boston

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