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Synthesis of Spacered Nucleoside Analogues Comprising a Difluorocyclopropane Moiety

  • René Csuk EMAIL logo and Gisela Thiede
Published/Copyright: June 2, 2014
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Zeitschrift für Naturforschung B
From the journal Zeitschrift für Naturforschung B Volume 58 Issue 9

A novel class of difluorinated cyclopropanoic nucleoside analogues containing a propyl spacer between the cyclopropane ring and the heterocycle has been prepared. Some of these compounds showed weak antitumor activity in prelimary screenings. The resolution of these racemic compounds on an analytical scale was performed by HPLC using chiral stationary phases.

Keywords : Nucleoside Analogues; Cyclopropanes; HPLC
Received: 2003-6-5
Published Online: 2014-6-2
Published in Print: 2003-9-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

Articles in the same Issue

  1. ERRATUM
  2. Asymmetric Catalysis, 154 [1]. New 1,1’-Binaphthyl Ligands for Enantioselective Catalysis
  3. Ternary Gallides REMgGa (RE = Y, La, Pr, Nd, Sm–Tm, Lu) – Synthesis and Crystal Chemistry
  4. Organometallic Compounds of the Lanthanides 169. Lanthanidocene Complexes Containing Chiral Nitrogen-Functionalized Cyclopentadienyl Ligands
  5. Structural Features of a Sulfur-Containing Group 4 Metalla[11]-crown-4 Derivative
  6. Synthesis of Cyclopropanoid Nucleoside Analogues Possessing a Flexible Side Chain
  7. Synthesis of Spacered Nucleoside Analogues Comprising a Difluorocyclopropane Moiety
  8. Synthesis of Some New Chiral Tricyclic and Macrocyclic Pyridine Derivatives as Antimicrobial Agents
  9. Molecular Complexes, 14. Isomeric Arene Complexes of Caffeine and 1,3,7,9-Tetramethyluric Acid Detected with Toluene. Polar Interactions Inverted with Hexafluorobenzene
  10. Synthesis and One-Electron Oxidation Chemistry of Stable β,β-Dimesityl Enols with Heteroaryl Substituents
  11. α-Dicarbonylmonohydrazone und ihre Acylderivate als Nucleophile und Nachbargruppen/α-Dicarbonylmonohydrazones and their Acylderivatives as Nucleophiles and Neighbouring Groups
  12. Synthesis of Some New (Nα-Dipicolinoyl)-bis-L-leucyl-DL-norvalyl Linear tetra and Cyclic octa Bridged Peptides as New Antiinflammatory Agents
  13. Synthesis, Characterisation and Structural Studies of [Zn(phen)3][Fe(CN)5(NO)]·2H2O·0.25MeOH and [(bipy)2(H2O)Zn(μ-NC)Fe(CN)4(NO)]·0.5H2O
  14. Photolysis of Naphthol Green B in Aqueous Solution. Photoreduction of Fe(III) Induced by Ligand-to-Metal Charge Transfer Excitation
  15. Crystal Structure of B-Type Tm2Si2O7 (≡Tm4[Si3O10][SiO4])
  16. Neue Strukturverfeinerung und Eigenschaften von Cr3C2/Structure Refinement and Properties of Cr3C2
https://doi.org/10.1515/znb-2003-0907
Keywords for this article
Nucleoside Analogues; Cyclopropanes; HPLC

Articles in the same Issue

  1. ERRATUM
  2. Asymmetric Catalysis, 154 [1]. New 1,1’-Binaphthyl Ligands for Enantioselective Catalysis
  3. Ternary Gallides REMgGa (RE = Y, La, Pr, Nd, Sm–Tm, Lu) – Synthesis and Crystal Chemistry
  4. Organometallic Compounds of the Lanthanides 169. Lanthanidocene Complexes Containing Chiral Nitrogen-Functionalized Cyclopentadienyl Ligands
  5. Structural Features of a Sulfur-Containing Group 4 Metalla[11]-crown-4 Derivative
  6. Synthesis of Cyclopropanoid Nucleoside Analogues Possessing a Flexible Side Chain
  7. Synthesis of Spacered Nucleoside Analogues Comprising a Difluorocyclopropane Moiety
  8. Synthesis of Some New Chiral Tricyclic and Macrocyclic Pyridine Derivatives as Antimicrobial Agents
  9. Molecular Complexes, 14. Isomeric Arene Complexes of Caffeine and 1,3,7,9-Tetramethyluric Acid Detected with Toluene. Polar Interactions Inverted with Hexafluorobenzene
  10. Synthesis and One-Electron Oxidation Chemistry of Stable β,β-Dimesityl Enols with Heteroaryl Substituents
  11. α-Dicarbonylmonohydrazone und ihre Acylderivate als Nucleophile und Nachbargruppen/α-Dicarbonylmonohydrazones and their Acylderivatives as Nucleophiles and Neighbouring Groups
  12. Synthesis of Some New (Nα-Dipicolinoyl)-bis-L-leucyl-DL-norvalyl Linear tetra and Cyclic octa Bridged Peptides as New Antiinflammatory Agents
  13. Synthesis, Characterisation and Structural Studies of [Zn(phen)3][Fe(CN)5(NO)]·2H2O·0.25MeOH and [(bipy)2(H2O)Zn(μ-NC)Fe(CN)4(NO)]·0.5H2O
  14. Photolysis of Naphthol Green B in Aqueous Solution. Photoreduction of Fe(III) Induced by Ligand-to-Metal Charge Transfer Excitation
  15. Crystal Structure of B-Type Tm2Si2O7 (≡Tm4[Si3O10][SiO4])
  16. Neue Strukturverfeinerung und Eigenschaften von Cr3C2/Structure Refinement and Properties of Cr3C2
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