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Metal Complexes of Biologically Important Ligands, CXXV [1]. Palladium(II) and Platinum(II) Complexes of Quinine Derivatives and in vitro Tests

  • Roland Hubel , Tomas Jelinek and Wolfgang Beck EMAIL logo
Published/Copyright: June 2, 2014
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Zeitschrift für Naturforschung B
From the journal Zeitschrift für Naturforschung B Volume 55 Issue 9

Several quinine substituted derivatives at the C(9)-O position (1 - 7) have been obtained from quinine and N-protected glycine chloride, chlorocarbonyl ferrocene, phenylisocyanate, dicarboxylic acid dichlorides or trimesinic trichloride. From these only the glycine derivative 1 showed significant antimalarial activity in in vitro tests against Plasmodium falciparum isolates. The quinine derivatives were used as ligands and from chloro bridged palladium and platinum complexes Cl(R3P)M(μ-Cl)2M(PR3)Cl (M = Pd, Pt) di-, tri-, tetra- and hexametallic compounds 8-21 with coordination both of the aliphatic and aromatic N-atoms were synthesized. Protection of the tertiary N atom by protonation gave the quinoline complexes 22-25. Using a stoichiometric ratio metal/ligand = 1/1 it could be shown that the coordination of metal ions at the quinoline N-atom is by far preferred. A titanium(IV) complex 36 is formulated as [Ti(quinine)3Cl]Cl3 with quinine as a zwitterionic ligand

: Quinine Derivatives; Palladium; Platinum
Received: 2000-3-13
Published Online: 2014-6-2
Published in Print: 2000-9-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

Articles in the same Issue

  1. Wechselwirkungen in Molekülkristallen, 156 [1, 2]. Kristallzüchtung und Strukturbestimmung von (Imidodiphosphat)-Alkalisalzen mit Kationen niedriger und hoher Koordinationszahlen / Interaction in Molecular Crystals, 156 [1, 2]. Crystal Growth and Structure Determination of Alkali(imidodiphosphate) Salts with Cations of Low and High Coordination Numbers
  2. Wechselwirkungen in Molekülkristallen, 157 [1, 2]. Mischkristallzüchtung und Strukturbestimmungen von Tetra(3,4-dimethylphenyl)-imidodiphosphat-Salzen mit Alkalikation- Verhältnissen K⊕/Rb⊕(1:5) und Rb⊕/Cs⊕(1:1) / Interaction in Molecular Crystals, 157 [1, 2]. Mixed Crystal Growth and Structure Determinations of Tetrakis(3,4-dimethylphenyl)-imidodiphosphate Salts with Alkali Cation Ratios K⊕/Rb⊕ (1:5) and Rb⊕/Cs⊕ (1:1)
  3. Synthesis, Crystal Structure and Magnetic Properties of a (μ-Hydroxo)(μ-Pyrazolato) Dicopper(II) Complex
  4. Polysulfonylamine, CXXVIII [1]. Disulfonylamido-Gold(I)-Komplexe mit Tetrahydrothiophen als Ligand / Polysulfonylamines, CXXVIII. Disulfonylamido-gold(I) Complexes with Tetrahydrothiophene as Ligand
  5. 1,1′-Di(tert-butyl)metallocenium Cations. The X-Ray Crystal Structures of [M(C5H4tBu)2]PF6 (M = Fe, Co) and [Co (C5H4t Bu)2]2CoCl4
  6. Metal Complexes of Biologically Important Ligands, CXXV [1]. Palladium(II) and Platinum(II) Complexes of Quinine Derivatives and in vitro Tests
  7. New Indides EuAuIn2, EuPdIn4, GdRhIn2, YbRhIn4, and YbPdIn4
  8. peri-Interactions in Naphthalenes, 4 [1]. Hypercoordination in 8-Dimethylamino-naphth-1-yl Phosphorus Compounds
  9. Metallkomplexe mit biologisch wichtigen Liganden, CXXVIII [1], Palladium(II)-Komplexe mit deprotonierten Peptidestern als N,N′-Chelatliganden / Metal Complexes with Biologically Important Ligands, CXXVIII [1]. Palladium(II) Complexes with Deprotonated Peptide Esters as N,N′-Chelate Ligands
  10. Structural and Spectral Studies of Palladium (II) Complexes of Pyridil bis{3-Piperidyl-, bis{Hexamethyleneiminyl-, bis{N(4)-Diethyl- and bis{N(4)-Dipropylthiosemicarbazone}
  11. Synthesis, Crystal Structures and Properties of the Polychalcogenides Manganese-tris(1,2-ethanediamine)-triselenide [Mn(en)3]Se3 and Manganese-tris(1,2-ethanediamine)-monotellurodiselenide [Mn(en)3 ]TeSe2
  12. Lewis-Säure/Base Addukte von TiCl4 und Methylpyridinen / Lewis Acid/Base Adducts of TiCl4 and Methylpyridines
  13. Darstellung und Charakterisierung des Silber(I,II,III)-oxidclathrates Ag7O8HCO3 / Synthesis and Characterization of the Silver(I,II,III) Oxide Clathrate Ag7O8HCO3
  14. ERRATUM
https://doi.org/10.1515/znb-2000-0906

Articles in the same Issue

  1. Wechselwirkungen in Molekülkristallen, 156 [1, 2]. Kristallzüchtung und Strukturbestimmung von (Imidodiphosphat)-Alkalisalzen mit Kationen niedriger und hoher Koordinationszahlen / Interaction in Molecular Crystals, 156 [1, 2]. Crystal Growth and Structure Determination of Alkali(imidodiphosphate) Salts with Cations of Low and High Coordination Numbers
  2. Wechselwirkungen in Molekülkristallen, 157 [1, 2]. Mischkristallzüchtung und Strukturbestimmungen von Tetra(3,4-dimethylphenyl)-imidodiphosphat-Salzen mit Alkalikation- Verhältnissen K⊕/Rb⊕(1:5) und Rb⊕/Cs⊕(1:1) / Interaction in Molecular Crystals, 157 [1, 2]. Mixed Crystal Growth and Structure Determinations of Tetrakis(3,4-dimethylphenyl)-imidodiphosphate Salts with Alkali Cation Ratios K⊕/Rb⊕ (1:5) and Rb⊕/Cs⊕ (1:1)
  3. Synthesis, Crystal Structure and Magnetic Properties of a (μ-Hydroxo)(μ-Pyrazolato) Dicopper(II) Complex
  4. Polysulfonylamine, CXXVIII [1]. Disulfonylamido-Gold(I)-Komplexe mit Tetrahydrothiophen als Ligand / Polysulfonylamines, CXXVIII. Disulfonylamido-gold(I) Complexes with Tetrahydrothiophene as Ligand
  5. 1,1′-Di(tert-butyl)metallocenium Cations. The X-Ray Crystal Structures of [M(C5H4tBu)2]PF6 (M = Fe, Co) and [Co (C5H4t Bu)2]2CoCl4
  6. Metal Complexes of Biologically Important Ligands, CXXV [1]. Palladium(II) and Platinum(II) Complexes of Quinine Derivatives and in vitro Tests
  7. New Indides EuAuIn2, EuPdIn4, GdRhIn2, YbRhIn4, and YbPdIn4
  8. peri-Interactions in Naphthalenes, 4 [1]. Hypercoordination in 8-Dimethylamino-naphth-1-yl Phosphorus Compounds
  9. Metallkomplexe mit biologisch wichtigen Liganden, CXXVIII [1], Palladium(II)-Komplexe mit deprotonierten Peptidestern als N,N′-Chelatliganden / Metal Complexes with Biologically Important Ligands, CXXVIII [1]. Palladium(II) Complexes with Deprotonated Peptide Esters as N,N′-Chelate Ligands
  10. Structural and Spectral Studies of Palladium (II) Complexes of Pyridil bis{3-Piperidyl-, bis{Hexamethyleneiminyl-, bis{N(4)-Diethyl- and bis{N(4)-Dipropylthiosemicarbazone}
  11. Synthesis, Crystal Structures and Properties of the Polychalcogenides Manganese-tris(1,2-ethanediamine)-triselenide [Mn(en)3]Se3 and Manganese-tris(1,2-ethanediamine)-monotellurodiselenide [Mn(en)3 ]TeSe2
  12. Lewis-Säure/Base Addukte von TiCl4 und Methylpyridinen / Lewis Acid/Base Adducts of TiCl4 and Methylpyridines
  13. Darstellung und Charakterisierung des Silber(I,II,III)-oxidclathrates Ag7O8HCO3 / Synthesis and Characterization of the Silver(I,II,III) Oxide Clathrate Ag7O8HCO3
  14. ERRATUM
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