Forced stability studies and estimation of encapsulated ellagic acid in nano-formulations using UV-spectroscopy
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Suraj Kumar
Suraj Kumar received his M.S. (Pharm.) in Pharmaceutics from the National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. His area of research is in the field of novel drug delivery systems, particularly drug targeting of colon cancer.
Yogesh Khairnar completed his M.S. (Pharm.) in Pharmaceutics from the National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. His area of research is enhancement of oral bioavailability of drugs.
Arka Karmakar is pursuing his Ph.D. in Pharmaceutics from the National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. His area of research is novel drug delivery systems.
Lalit Kumar received his Ph.D. in Pharmaceutical Sciences from Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India in 2016. He holds 3 Indian patents, has filed 7 patents, published 2 books, more than 35 book chapters and about 130 articles in peer-reviewed journals. He has about 15 years of teaching and research experience. His work includes novel drug delivery systems (especially nanoformulations), analytical method development and QbD. He has successfully completed more than ten research projects funded by AICTE, New Delhi, State of Karnataka VGST, Bengaluru, ICMR, New Delhi, SERB, New Delhi. He is currently working as Assistant Professor in the Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India.
Abstract
There is a growing interest in dietary materials to explore their therapeutic activities. Ellagic acid is considered as a dietary supplement and is naturally present in fruits and other foods. It has anticancer, antimalarial, antiviral, antioxidant, and anti-inflammatory activities. These activities can be enhanced with nanoformulations, which can increase its oral bioavailability. However, there is a need for an economical, simple, sensitive, and robust analytical method for the estimation of entrapped ellagic acid in the nanoformulations. Therefore, the present study presents the development and validation of a UV–visible spectroscopy method for the estimation of EA in nanoformulations. The phosphate buffer (pH 7.2) and the detection wavelength of 253.5 nm were used for the method development, and its validation was performed according to the ICH Q2A (R1) guidelines. The coefficient of determination value of the developed method was found to be 0.9988 in the concentration range of 1 μg mL−1 to 6 μg mL−1. The method was found to be linear, precise, sensitive, and robust. This method can be used for the estimation of EA in nanoformulations, bulk dosage forms, and other pharmaceutical formulations.
About the authors
Suraj Kumar received his M.S. (Pharm.) in Pharmaceutics from the National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. His area of research is in the field of novel drug delivery systems, particularly drug targeting of colon cancer.
Yogesh Khairnar completed his M.S. (Pharm.) in Pharmaceutics from the National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. His area of research is enhancement of oral bioavailability of drugs.
Arka Karmakar is pursuing his Ph.D. in Pharmaceutics from the National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. His area of research is novel drug delivery systems.
Lalit Kumar received his Ph.D. in Pharmaceutical Sciences from Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India in 2016. He holds 3 Indian patents, has filed 7 patents, published 2 books, more than 35 book chapters and about 130 articles in peer-reviewed journals. He has about 15 years of teaching and research experience. His work includes novel drug delivery systems (especially nanoformulations), analytical method development and QbD. He has successfully completed more than ten research projects funded by AICTE, New Delhi, State of Karnataka VGST, Bengaluru, ICMR, New Delhi, SERB, New Delhi. He is currently working as Assistant Professor in the Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India.
Acknowledgments
The authors would like to acknowledge the National Institute of Pharmaceutical Education and Research, Hajipur, Vaishali, Bihar, India, for providing the infrastructural facilities to complete this research.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interests: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Not applicable.
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© 2024 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Discussion
- How to better realise the potential of automatic dishwashing to reduce the energy (and water) use in European households: introduction of a ‘short eco’ programme
- Physical Chemistry
- Ionic surfactants critical micelle concentration modelling in water/organic solvent mixtures using random forest and support vector machine algorithms
- Research on a synergistic formula of anionic and betaine type surfactants for natural gas fields
- Effect of amphiphilic nanoparticles and non-ionic surfactants on emulsion stability
- Rheology on novel UV–light irradiation thinning and thickening viscoelastic oleamidopropyl dimethylamine/trans-o-methoxycinnamic acid micelle systems
- Applications
- Forced stability studies and estimation of encapsulated ellagic acid in nano-formulations using UV-spectroscopy
- Cloud point extraction of heavy metal ions for wastewater remediation: an equilibrium and kinetic study
- Development and blocking assessment of high softening point asphalt system
- Short Communication
- Effect of hydrophile–lipophile balance of F-alkylated cyclic polyethylene glycol succinates on their applications
Articles in the same Issue
- Frontmatter
- Discussion
- How to better realise the potential of automatic dishwashing to reduce the energy (and water) use in European households: introduction of a ‘short eco’ programme
- Physical Chemistry
- Ionic surfactants critical micelle concentration modelling in water/organic solvent mixtures using random forest and support vector machine algorithms
- Research on a synergistic formula of anionic and betaine type surfactants for natural gas fields
- Effect of amphiphilic nanoparticles and non-ionic surfactants on emulsion stability
- Rheology on novel UV–light irradiation thinning and thickening viscoelastic oleamidopropyl dimethylamine/trans-o-methoxycinnamic acid micelle systems
- Applications
- Forced stability studies and estimation of encapsulated ellagic acid in nano-formulations using UV-spectroscopy
- Cloud point extraction of heavy metal ions for wastewater remediation: an equilibrium and kinetic study
- Development and blocking assessment of high softening point asphalt system
- Short Communication
- Effect of hydrophile–lipophile balance of F-alkylated cyclic polyethylene glycol succinates on their applications
