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Exploring the latest findings on endovascular treatments for giant aneurysms: a review

  • David-Dimitris Chlorogiannis ORCID logo EMAIL logo , Athina-Maria Aloizou , Anargyros Chlorogiannis , Nefeli Kosta , Jonathan Andreas Sänger , Achilles Chatziioannou and Panagiotis Papanagiotou
Published/Copyright: January 1, 2024
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Abstract

Giant intracranial aneurysms represent a very challenging aspect of aneurysmal pathophysiology with very high mortality and morbidity if left untreated. Their variety in clinical presentation (subarachnoid hemorrhage, cranial nerve palsy, etc.) and pathological and imaging properties (location, anatomy, presence of collateral circulation) pose serious questions regarding the best treatment option. Admirable advances have been achieved in surgical techniques, while endovascular modalities with flow diversion techniques have become widely used. However, there is still lack of data regarding whether a single endovascular technique can be the universal treatment for such cases. In this review, we aim to summarize the current funds of knowledge concerning giant intracranial aneurysms and the role of endovascular management in their treatment.


Corresponding author: David-Dimitris Chlorogiannis, Department of Radiology, Brigham and Womens Hospital, Boston, MA 02115, USA, E-mail:

  1. Research ethics: Not applicable.

  2. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors state no conflict of interest.

  4. Research funding: None declared.

  5. Data availability: Not applicable.

References

Aenis, M., Stancampiano, A.P., Wakhloo, A.K., and Lieber, B.B. (1997). Modeling of flow in a straight stented and nonstented side wall aneurysm model. J. Biomech. Eng. 119: 206–212, https://doi.org/10.1115/1.2796081.Search in Google Scholar PubMed

Ansari, A., Kalyan, S., Sae-Ngow, T., Yamada, Y., Tanaka, R., Kawase, T., and Kato, Y. (2019). Review of avoidance of complications in cerebral aneurysm surgery: the Fujita experience. Asian J. Neurosurg. 14: 686–692, https://doi.org/10.4103/ajns.ajns_131_17.Search in Google Scholar

Anson, J.A., Lawton, M.T., and Spetzler, R.F. (1996). Characteristics and surgical treatment of dolichoectatic and fusiform aneurysms. J. Neurosurg. 84: 185–193, https://doi.org/10.3171/jns.1996.84.2.0185.Search in Google Scholar PubMed

Aoki, T., Kataoka, H., Morimoto, M., Nozaki, K., and Hashimoto, N. (2007). Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. Stroke 38: 162–169, https://doi.org/10.1161/01.str.0000252129.18605.c8.Search in Google Scholar PubMed

Arambepola, P.K., McEvoy, S.D., and Bulsara, K.R. (2010). De novo aneurysm formation after carotid artery occlusion for cerebral aneurysms. Skull Base 20: 405–408, https://doi.org/10.1055/s-0030-1253578.Search in Google Scholar PubMed PubMed Central

Austin, G., Fisher, S., Dickson, D., Anderson, D., and Richardson, S. (1993). The significance of the extracellular matrix in intracranial aneurysms. Ann. Clin. Lab. Sci. 23: 97–105.Search in Google Scholar

Bakker, M.K. and Ruigrok, Y.M. (2021). Genetics of intracranial aneurysms. Stroke 52: 3004–3012, https://doi.org/10.1161/strokeaha.120.032621.Search in Google Scholar PubMed

Bechan, R.S., Majoie, C.B., Sprengers, M.E., Peluso, J.P., Sluzewski, M., and van Rooij, W.J. (2016). Therapeutic internal carotid artery occlusion for large and giant aneurysms: a single center cohort of 146 patients. AJNR Am. J. Neuroradiol. 37: 125–129, https://doi.org/10.3174/ajnr.a4487.Search in Google Scholar PubMed PubMed Central

Becske, T., Kallmes, D.F., Saatci, I., McDougall, C.G., Szikora, I., Lanzino, G., Moran, C.J., Woo, H.H., Lopes, D.K., Berez, A.L., et al.. (2013). Pipeline for uncoilable or failed aneurysms: results from a multicenter clinical trial. Radiology 267: 858–868, https://doi.org/10.1148/radiol.13120099.Search in Google Scholar PubMed

Bender, M.T., Colby, G.P., Lin, L.M., Jiang, B., Westbroek, E.M., Xu, R., Campos, J.K., Huang, J., Tamargo, R.J., and Coon, A.L. (2018). Predictors of cerebral aneurysm persistence and occlusion after flow diversion: a single-institution series of 445 cases with angiographic follow-up. J. Neurosurg. 130: 259–267, https://doi.org/10.3171/2017.11.JNS171738.Search in Google Scholar PubMed

Boissonneau, S., Graillon, T., Meyer, M., Brunel, H., Fuentes, S., and Dufour, H. (2018). Intracranial giant mycotic aneurysm without endocarditis and vasculitis: report of rare entity and review of literature. World Neurosurg. 119: 353–357, https://doi.org/10.1016/j.wneu.2018.08.086.Search in Google Scholar PubMed

Bor, A.S., Koffijberg, H., Wermer, M.J., and Rinkel, G.J. (2010). Optimal screening strategy for familial intracranial aneurysms: a cost-effectiveness analysis. Neurology 74: 1671–1679, https://doi.org/10.1212/wnl.0b013e3181e04297.Search in Google Scholar PubMed

Bothun, M.L., Haaland, O.A., Logallo, N., Svendsen, F., Thomassen, L., and Helland, C.A. (2018). Time course of cerebrovascular reactivity in patients treated for unruptured intracranial aneurysms: a one-year transcranial Doppler and acetazolamide follow-up study. Biomed Res. Int. 2018: 6489276, https://doi.org/10.1155/2018/6489276.Search in Google Scholar PubMed PubMed Central

Brinjikji, W., Murad, M.H., Lanzino, G., Cloft, H.J., and Kallmes, D.F. (2013). Endovascular treatment of intracranial aneurysms with flow diverters: a meta-analysis. Stroke 44: 442–447, https://doi.org/10.1161/strokeaha.112.678151.Search in Google Scholar PubMed

Brown, R.D.Jr. and Broderick, J.P. (2014). Unruptured intracranial aneurysms: epidemiology, natural history, management options, and familial screening. Lancet Neurol. 13: 393–404, https://doi.org/10.1016/s1474-4422(14)70015-8.Search in Google Scholar PubMed

Cagnazzo, F., Mantilla, D., Rouchaud, A., Brinjikji, W., Lefevre, P.H., Dargazanli, C., Gascou, G., Riquelme, C., Perrini, P., di Carlo, D., et al.. (2018). Endovascular treatment of very large and giant intracranial aneurysms: comparison between reconstructive and deconstructive techniques-A meta-analysis. AJNR Am. J. Neuroradiol. 39: 852–858, https://doi.org/10.3174/ajnr.a5591.Search in Google Scholar PubMed PubMed Central

Cantore, G., Santoro, A., Guidetti, G., Delfinis, C.P., Colonnese, C., and Passacantilli, E. (2008). Surgical treatment of giant intracranial aneurysms: current viewpoint. Neurosurgery 63: 279–289, discussion 289–290, https://doi.org/10.1227/01.neu.0000313122.58694.91.Search in Google Scholar

Cares, H.L., Hale, J.R., Montgomery, D.B., Richter, H.A., and Sweet, W.H. (1973). Laboratory experience with a magnetically guided intravascular catheter system. J. Neurosurg. 38: 145–154, https://doi.org/10.3171/jns.1973.38.2.0145.Search in Google Scholar PubMed

Chalouhi, N., Ali, M.S., Jabbour, P.M., Tjoumakaris, S.I., Gonzalez, L.F., Rosenwasser, R.H., Koch, W.J., and Dumont, A.S. (2012). Biology of intracranial aneurysms: role of inflammation. J. Cereb. Blood Flow. Metab. 32: 1659–1676, https://doi.org/10.1038/jcbfm.2012.84.Search in Google Scholar PubMed PubMed Central

Chalouhi, N., Hoh, B.L., and Hasan, D. (2013). Review of cerebral aneurysm formation, growth, and rupture. Stroke 44: 3613–3622, https://doi.org/10.1161/strokeaha.113.002390.Search in Google Scholar PubMed

Chalouhi, N., Tjoumakaris, S., Gonzalez, L.F., Dumont, A.S., Starke, R.M., Hasan, D., Wu, C., Singhal, S., Moukarzel, L.A., Rosenwasser, R., et al.. (2014). Coiling of large and giant aneurysms: complications and long-term results of 334 cases. AJNR Am. J. Neuroradiol. 35: 546–552, https://doi.org/10.3174/ajnr.a3696.Search in Google Scholar

Chen, J., Li, M., Zhu, X., Chen, Y., Zhang, C., Shi, W., Chen, Q., and Wang, Y. (2020). Anterior communicating artery aneurysms: anatomical considerations and microsurgical strategies. Front. Neurol. 11: 1020, https://doi.org/10.3389/fneur.2020.01020.Search in Google Scholar PubMed PubMed Central

Choi, I.S. and David, C. (2003). Giant intracranial aneurysms: development, clinical presentation and treatment. Eur. J. Radiol. 46: 178–194, https://doi.org/10.1016/s0720-048x(03)00090-1.Search in Google Scholar PubMed

Christiano, L.D., Gupta, G., Prestigiacomo, C.J., and Gandhi, C.D. (2009). Giant serpentine aneurysms. Neurosurg. Focus 26: E5, https://doi.org/10.3171/2009.2.focus0918.Search in Google Scholar

Clarencon, F., Bonneville, F., Boch, A.L., Lejean, L., and Biondi, A. (2011). Parent artery occlusion is not obsolete in giant aneurysms of the ICA. Experience with very-long-term follow-up. Neuroradiology 53: 973–982, https://doi.org/10.1007/s00234-010-0800-8.Search in Google Scholar PubMed

Cun, Y.P., Xiong, C.J., Diao, B., Yang, Y., Pan, L., and Ma, L.T. (2017). Association between angiotensin-converting enzyme insertion/deletion polymorphisms and intracranial aneurysm susceptibility: a meta-analysis. Biomed. Rep. 6: 663–670, https://doi.org/10.3892/br.2017.893.Search in Google Scholar PubMed PubMed Central

Dao, W., Xiao, Z., Kong, Z., Jiang, J., and Lu, Z. (2021). Clinical characteristics and endovascular treatment in patients with intracranial giant serpentine aneurysms. Quant. Imag. Med. Surg. 11: 1490–1495, https://doi.org/10.21037/qims-20-698.Search in Google Scholar PubMed PubMed Central

Dengler, J., Maldaner, N., Glasker, S., Endres, M., Wagner, M., Malzahn, U., Heuschmann, P.U., and Vajkoczy, P., and Giant Intracranial Aneurysm Study, G (2016). Outcome of surgical or endovascular treatment of giant intracranial aneurysms, with emphasis on age, aneurysm location, and unruptured aneuryms – A systematic review and meta-analysis. Cerebrovasc. Dis. 41: 187–198, https://doi.org/10.1159/000443485.Search in Google Scholar PubMed

Derrey, S., Penchet, G., Thines, L., Lonjon, M., David, P., Bataille, B., Emery, E., Lubrano, V., Laguarrigue, J., Bresson, D., et al.. (2015). French collaborative group series on giant intracranial aneurysms: current management. Neurochirurgie 61: 371–377, https://doi.org/10.1016/j.neuchi.2013.11.006.Search in Google Scholar PubMed

Drake, C.G. (1979). Giant intracranial aneurysms: experience with surgical treatment in 174 patients. Clin. Neurosurg. 26: 12–95, https://doi.org/10.1093/neurosurgery/26.cn_suppl_1.12.Search in Google Scholar PubMed

Etminan, N. and Rinkel, G.J. (2016). Unruptured intracranial aneurysms: development, rupture and preventive management. Nat. Rev. Neurol. 12: 699–713, https://doi.org/10.1038/nrneurol.2016.150.Search in Google Scholar PubMed

Fernandez Zubillaga, A., Guglielmi, G., Vinuela, F., and Duckwiler, G.R. (1994). Endovascular occlusion of intracranial aneurysms with electrically detachable coils: correlation of aneurysm neck size and treatment results. AJNR Am. J. Neuroradiol. 15: 815–820.Search in Google Scholar

Fiorella, D., Albuquerque, F.C., Deshmukh, V.R., and McDougall, C.G. (2005). Usefulness of the Neuroform stent for the treatment of cerebral aneurysms: results at initial (3-6-mo) follow-up. Neurosurgery 56: 1191–1201, discussion 1201-1192, https://doi.org/10.1227/01.neu.0000159645.86823.af.Search in Google Scholar PubMed

Fodstad, H., Liliequist, B., Wirell, S., Nilsson, P.E., Boquist, L., and Abdul-Rahman, A. (1978). Giant serpentine intracranial aneurysm after carotid ligation. Case Report. J. Neurosurg. 49: 903–909, https://doi.org/10.3171/jns.1978.49.6.0903.Search in Google Scholar PubMed

Foroud, T., Sauerbeck, L., Brown, R., Anderson, C., Woo, D., Kleindorfer, D., Flaherty, M.L., Deka, R., Hornung, R., Meissner, I., et al.., and Familial Intracranial Aneurysm Study, I. (2009). Genome screen in familial intracranial aneurysm. BMC Med. Genet. 10: 3, https://doi.org/10.1186/1471-2350-10-3.Search in Google Scholar PubMed PubMed Central

Foroud, T., Sauerbeck, L., Brown, R., Anderson, C., Woo, D., Kleindorfer, D., Flaherty, M.L., Deka, R., Hornung, R., Meissner, I., et al.. (2008). Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study. Stroke 39: 1434–1440, https://doi.org/10.1161/strokeaha.107.502930.Search in Google Scholar

Gan, Q., Liu, Q., Hu, X., and You, C. (2017). Collagen type I alpha 2 (COL1A2) polymorphism contributes to intracranial aneurysm susceptibility: a meta-analysis. Med. Sci. Mon. 23: 3240–3246, https://doi.org/10.12659/msm.902327.Search in Google Scholar PubMed PubMed Central

Ganesh Kumar, N., Ladner, T.R., Kahn, I.S., Zuckerman, S.L., Baker, C.B., Skaletsky, M., Cushing, D., Sanborn, M.R., Mocco, J., and Ecker, R.D. (2017). Parent vessel occlusion for treatment of cerebral aneurysms: is there still an indication? A series of 17 patients. J. Neurol. Sci. 372: 250–255, https://doi.org/10.1016/j.jns.2016.11.057.Search in Google Scholar PubMed

Garg, K., Singh, P.K., Sharma, B.S., Chandra, P.S., Suri, A., Singh, M., Kumar, R., Kale, S.S., Mishra, N.K., Gaikwad, S.K., et al.. (2014). Pediatric intracranial aneurysms – our experience and review of literature. Childs Nerv. Syst. 30: 873–883, https://doi.org/10.1007/s00381-013-2336-9.Search in Google Scholar PubMed

Gmeiner, M. and Gruber, A. (2021). Current strategies in the treatment of intracranial large and giant aneurysms. In: Esposito, G., Regli, L., Cenzato, M., Kaku, Y., Tanaka, M., and Tsukahara, T. (Eds.), Trends in cerebrovascular surgery and interventions. Springer, Cham (CH), pp. 19–26.10.1007/978-3-030-63453-7_3Search in Google Scholar PubMed

Go, A.S., Mozaffarian, D., Roger, V.L., Benjamin, E.J., Berry, J.D., Blaha, M.J., Dai, S., Ford, E.S., Fox, C.S., Franco, S., American Heart Association Statistics, C., and Stroke Statistics, S (2014). Heart disease and stroke statistics – 2014 update: a report from the American Heart Association. Circulation 129: e28–e292, https://doi.org/10.1161/01.cir.0000441139.02102.80.Search in Google Scholar PubMed PubMed Central

Gruber, A., Killer, M., Bavinzski, G., and Richling, B. (1999). Clinical and angiographic results of endosaccular coiling treatment of giant and very large intracranial aneurysms: a 7-year, single-center experience. Neurosurgery 45: 793–803, discussion 803–794, https://doi.org/10.1097/00006123-199910000-00013.Search in Google Scholar PubMed

Guglielmi, G., Vinuela, F., Dion, J., and Duckwiler, G. (1991a). Electrothrombosis of saccular aneurysms via endovascular approach. Part 2: preliminary clinical experience. J. Neurosurg. 75: 8–14, https://doi.org/10.3171/jns.1991.75.1.0008.Search in Google Scholar PubMed

Guglielmi, G., Vinuela, F., Sepetka, I., and Macellari, V. (1991b). Electrothrombosis of saccular aneurysms via endovascular approach. Part 1: electrochemical basis, technique, and experimental results. J. Neurosurg. 75: 1–7, https://doi.org/10.3171/jns.1991.75.1.0001.Search in Google Scholar PubMed

Guo, H., Liu, J.F., Li, C.H., Wang, J.W., Li, H., and Gao, B.L. (2022). Effects of stent-assisted coiling in comparison with flow diversion on intracranial aneurysms. Front. Neurol. 13: 937536, https://doi.org/10.3389/fneur.2022.937536.Search in Google Scholar PubMed PubMed Central

Hampton, T., Walsh, D., Tolias, C., and Fiorella, D. (2011). Mural destabilization after aneurysm treatment with a flow-diverting device: a report of two cases. J. Neurointerventional Surg. 3: 167–171, https://doi.org/10.1136/jnis.2010.002873.Search in Google Scholar PubMed

Hasan, D., Chalouhi, N., Jabbour, P., and Hashimoto, T. (2012a). Macrophage imbalance (M1 vs. M2) and upregulation of mast cells in wall of ruptured human cerebral aneurysms: preliminary results. J. Neuroinflammation. 9: 222, https://doi.org/10.1186/1742-2094-9-222.Search in Google Scholar PubMed PubMed Central

Hasan, D.M., Nadareyshvili, A.I., Hoppe, A.L., Mahaney, K.B., Kung, D.K., and Raghavan, M.L. (2012b). Cerebral aneurysm sac growth as the etiology of recurrence after successful coil embolization. Stroke 43: 866–868, https://doi.org/10.1161/strokeaha.111.637827.Search in Google Scholar PubMed PubMed Central

Hasan, D.M., Chalouhi, N., Jabbour, P., Dumont, A.S., Kung, D.K., Magnotta, V.A., Young, W.L., Hashimoto, T., Richard Winn, H., and Heistad, D. (2013). Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results. J. Am. Heart Assoc. 2: e000019, https://doi.org/10.1161/jaha.112.000019.Search in Google Scholar PubMed PubMed Central

Hecht, S.T., Horton, J.A., and Yonas, H. (1991). Growth of a thrombosed giant vertebral artery aneurysm after parent artery occlusion. AJNR Am. J. Neuroradiol. 12: 449–451.Search in Google Scholar

Hilal, S.K., Khandji, A., and Solomon, R.W. (1989). Obliteration of intracranial aneurysms with pre-shaped highly thrombogenic coils. Radiology 173: 250–257.Search in Google Scholar

Hoi, Y., Ionita, C.N., Tranquebar, R.V., Hoffmann, K.R., Woodward, S.H., Taulbee, D.B., Meng, H., and Rudin, S. (2006). Flow modification in canine intracranial aneurysm model by an asymmetric stent: studies using digital subtraction angiography (DSA) and image-based computational fluid dynamics (CFD) analyses. Proc. SPIE Int. Soc. Opt. Eng. 6143: 61430J, https://doi.org/10.1117/12.650624.Search in Google Scholar PubMed PubMed Central

Hu, X., Fang, Y., Li, Y.K., Liu, W.K., Li, H., Ma, L., and You, C. (2015). Role of endoglin insertion and rs1800956 polymorphisms in intracranial aneurysm susceptibility: a meta-analysis. Medicine 94: e1847, https://doi.org/10.1097/md.0000000000001847.Search in Google Scholar PubMed PubMed Central

Inci, S. and Karakaya, D. (2023). Microsurgical treatment of previously coiled giant aneurysms: experience with 6 cases and literature review. World Neurosurg. 171: e336–e348, https://doi.org/10.1016/j.wneu.2022.12.016.Search in Google Scholar PubMed

Investigators, U.J., Morita, A., Kirino, T., Hashi, K., Aoki, N., Fukuhara, S., Hashimoto, N., Nakayama, T., Sakai, M., Teramoto, A., et al.. (2012). The natural course of unruptured cerebral aneurysms in a Japanese cohort. N. Engl. J. Med. 366: 2474–2482, https://doi.org/10.1056/nejmoa1113260.Search in Google Scholar PubMed

Johnston, S.C., Selvin, S., and Gress, D.R. (1998). The burden, trends, and demographics of mortality from subarachnoid hemorrhage. Neurology 50: 1413–1418, https://doi.org/10.1212/wnl.50.5.1413.Search in Google Scholar PubMed

Katayama, Y., Tsubokawa, T., Miyazaki, S., Furuichi, M., Hirayama, T., and Himi, K. (1991). Growth of totally thrombosed giant aneurysm within the posterior cranial fossa. Diagnostic and therapeutic considerations. Neuroradiology 33: 168–170, https://doi.org/10.1007/bf00588260.Search in Google Scholar PubMed

Labeyrie, M.A., Lenck, S., Bresson, D., Desilles, J.P., Bisdorff, A., Saint-Maurice, J.P., and Houdart, E. (2015). Parent artery occlusion in large, giant, or fusiform aneurysms of the carotid siphon: clinical and imaging results. AJNR Am. J. Neuroradiol. 36: 140–145, https://doi.org/10.3174/ajnr.a4064.Search in Google Scholar

Lall, R.R., Eddleman, C.S., Bendok, B.R., and Batjer, H.H. (2009). Unruptured intracranial aneurysms and the assessment of rupture risk based on anatomical and morphological factors: sifting through the sands of data. Neurosurg. Focus 26: E2, https://doi.org/10.3171/2009.2.focus0921.Search in Google Scholar PubMed

Lawton, M.T. and Spetzler, R.F. (1999). Surgical strategies for giant intracranial aneurysms. Acta Neurochir. Suppl. 72: 141–156, https://doi.org/10.1007/978-3-7091-6377-1_12.Search in Google Scholar PubMed

Li, H., Gao, B.L., Li, C.H., Wang, J.W., Liu, J.F., and Yang, S.T. (2020). Endovascular retreatment of cerebral aneurysms previously treated with endovascular embolization. J. Neurol. Surg. A Cent. Eur. Neurosurg. 81: 207–212, https://doi.org/10.1055/s-0039-1685513.Search in Google Scholar PubMed

Lin, N., Brouillard, A.M., Krishna, C., Mokin, M., Natarajan, S.K., Sonig, A., Snyder, K.V., Levy, E.I., and Siddiqui, A.H. (2015). Use of coils in conjunction with the pipeline embolization device for treatment of intracranial aneurysms. Neurosurgery 76: 142–149, https://doi.org/10.1227/neu.0000000000000579.Search in Google Scholar

Lonjon, M., Pennes, F., Sedat, J., and Bataille, B. (2015). Epidemiology, genetic, natural history and clinical presentation of giant cerebral aneurysms. Neurochirurgie 61: 361–365, https://doi.org/10.1016/j.neuchi.2015.08.003.Search in Google Scholar PubMed

Luessenhop, A.J. and Velasquez, A.C. (1964). Observations on the tolerance of the intracranial arteries to catheterization. J. Neurosurg. 21: 85–91, https://doi.org/10.3171/jns.1964.21.2.0085.Search in Google Scholar PubMed

Malisch, T.W., Guglielmi, G., Vinuela, F., Duckwiler, G., Gobin, Y.P., Martin, N.A., and Frazee, J.G. (1997). Intracranial aneurysms treated with the Guglielmi detachable coil: midterm clinical results in a consecutive series of 100 patients. J. Neurosurg. 87: 176–183, https://doi.org/10.3171/jns.1997.87.2.0176.Search in Google Scholar PubMed

Merei, F.T. and Gallyas, F. (1980). Role of the structural elements of the arterial wall in the formation and growth of intracranial saccular aneurysms. Neurol. Res. 2: 283–303, https://doi.org/10.1080/01616412.1980.11739584.Search in Google Scholar PubMed

Meyers, P.M., Coon, A.L., Kan, P.T., Wakhloo, A.K., and Hanel, R.A. (2019). SCENT trial. Stroke 50: 1473–1479, https://doi.org/10.1161/strokeaha.118.024135.Search in Google Scholar PubMed

Miller, J.D., Jawad, K., and Jennett, B. (1977). Safety of carotid ligation and its role in the management of intracranial aneurysms. J. Neurol. Neurosurg. Psychiatr. 40: 64–72, https://doi.org/10.1136/jnnp.40.1.64.Search in Google Scholar PubMed PubMed Central

Montgomery, D., Hale, J., Pierce, N., and Yodh, S. (1970). A magnetically guided catheter system for intercranial use in man. IEEE Trans. Magn. 6, https://doi.org/10.1109/tmag.1970.1066786.Search in Google Scholar

Moon, J., Cho, Y.D., Yoo, D.H., Lee, J., Kang, H.S., Cho, W.S., Kim, J.E., Zhang, L., and Han, M.H. (2019). Growth of asymptomatic intracranial fusiform aneurysms: incidence and risk factors. Clin. Neuroradiol. 29: 717–723, https://doi.org/10.1007/s00062-018-0695-z.Search in Google Scholar PubMed

Moret, J., Cognard, C., Weill, A., Castaings, L., and Rey, A. (1997). The “Remodelling Technique” in the treatment of wide neck intracranial aneurysms. Angiographic results and clinical follow-up in 56 cases. Interv. Neurol. 3: 21–35, https://doi.org/10.1177/159101999700300103.Search in Google Scholar PubMed

Nahed, B.V., Seker, A., Guclu, B., Ozturk, A.K., Finberg, K., Hawkins, A.A., DiLuna, M.L., State, M., Lifton, R.P., and Gunel, M. (2005). Mapping a Mendelian form of intracranial aneurysm to 1p34.3-p36.13. Am. J. Hum. Genet. 76: 172–179, https://doi.org/10.1086/426953.Search in Google Scholar PubMed PubMed Central

Nakajima, N., Nagahiro, S., Sano, T., Satomi, J., and Satoh, K. (2000). Phenotypic modulation of smooth muscle cells in human cerebral aneurysmal walls. Acta Neuropathol. 100: 475–480, https://doi.org/10.1007/s004010000220.Search in Google Scholar PubMed

Nakajima, N., Nagahiro, S., Sano, T., Satomi, J., Tada, Y., Yagi, K., Kitazato, K.T., and Satoh, K. (2012). Kruppel-like zinc-finger transcription factor 5 (KLF5) is highly expressed in large and giant unruptured cerebral aneurysms. World Neurosurg. 78: 114–121, https://doi.org/10.1016/j.wneu.2011.05.052.Search in Google Scholar PubMed

Nanda, A., Sonig, A., Banerjee, A.D., and Javalkar, V.K. (2014). Microsurgical management of giant intracranial aneurysms: a single surgeon experience from Louisiana State University, Shreveport. World Neurosurg. 81: 752–764, https://doi.org/10.1016/j.wneu.2012.12.010.Search in Google Scholar PubMed

Nishi, H., Ishii, A., Satow, T., Iihara, K., Sakai, N. and Japanese Registry of Neuroendovascular Therapy, I (2019). Parent artery occlusion for unruptured cerebral aneurysms: results of the Japanese registry of neuroendovascular therapy 3. Neurol. Med. Chir. 59: 1–9, https://doi.org/10.2176/nmc.st.2018-0190.Search in Google Scholar PubMed PubMed Central

Nossek, E., Chalif, D.J., Chakraborty, S., Lombardo, K., Black, K.S., and Setton, A. (2015). Concurrent use of the Pipeline Embolization Device and coils for intracranial aneurysms: technique, safety, and efficacy. J. Neurosurg. 122: 904–911, https://doi.org/10.3171/2014.12.jns141259.Search in Google Scholar

Parkinson, R.J., Eddleman, C.S., Batjer, H.H., and Bendok, B.R. (2006). Giant intracranial aneurysms: endovascular challenges. Neurosurgery 59: S103–S112, discussion S103-113, https://doi.org/10.1227/01.neu.0000237410.32115.c9.Search in Google Scholar PubMed

Paschoal, E.H.A., Yamaki, V.N., Teixeira, R.K.C., Paschoal Junior, F.M., Jong, A.L.G.S., Teixeira, M.J., Yamada, E.S., Ribeiro-Dos-Santos, A., and Bor-Seng-Shu, E. (2018). Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis. Neurosurg. Rev. 41: 87–94, https://doi.org/10.1007/s10143-016-0761-4.Search in Google Scholar PubMed

Paterakis, K., Koutsias, S., Doxani, C., Xanthopoulou, P., Kokkali, C., Mpoulimari, I., Tziastoudi, M., Karampelas, I., Dardiotis, E., Hadjigeorgiou, G., et al.. (2017). Variants of the elastin (ELN) gene and susceptibility to intracranial aneurysm: a synthesis of genetic association studies using a genetic model-free approach. Int. J. Neurosci. 127: 567–572, https://doi.org/10.1080/00207454.2016.1212027.Search in Google Scholar PubMed

Peschillo, S., Caporlingua, A., Resta, M.C., Peluso, J.P.P., Burdi, N., Sourour, N., Diana, F., Guidetti, G., Clarencon, F., Bloemsma, G.C., et al.. (2017). Endovascular treatment of large and giant carotid aneurysms with flow-diverter stents alone or in combination with coils: a multicenter experience and long-term follow-up. Oper. Neurosurg. 13: 492–502, https://doi.org/10.1093/ons/opx032.Search in Google Scholar PubMed

Pritz, M.B. (2011). Cerebral aneurysm classification based on angioarchitecture. J. Stroke Cerebrovasc. Dis. 20: 162–167, https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.11.018.Search in Google Scholar PubMed

Rinkel, G.J. (2005). Intracranial aneurysm screening: indications and advice for practice. Lancet Neurol. 4: 122–128, https://doi.org/10.1016/s1474-4422(05)00993-2.Search in Google Scholar PubMed

Rinkel, G.J., Djibuti, M., Algra, A., and van Gijn, J. (1998). Prevalence and risk of rupture of intracranial aneurysms: a systematic review. Stroke 29: 251–256, https://doi.org/10.1161/01.str.29.1.251.Search in Google Scholar PubMed

Ronkainen, A., Hernesniemi, J., Puranen, M., Niemitukia, L., Vanninen, R., Ryynanen, M., Kuivaniemi, H., and Tromp, G. (1997). Familial intracranial aneurysms. Lancet 349: 380–384, https://doi.org/10.1016/s0140-6736(97)80009-8.Search in Google Scholar

Ruigrok, Y.M., Rinkel, G.J., Wijmenga, C., Kasuya, H., Tajima, A., Takahashi, T., Hata, A., Inoue, I., and Krischek, B. (2009). Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort. Cerebrovasc. Dis. 28: 131–134, https://doi.org/10.1159/000223438.Search in Google Scholar PubMed

Ruigrok, Y.M., Wijmenga, C., Rinkel, G.J., van’t Slot, R., Baas, F., Wolfs, M., Westerveld, A., and Roos, Y.B. (2008). Genomewide linkage in a large Dutch family with intracranial aneurysms: replication of 2 loci for intracranial aneurysms to chromosome 1p36.11-p36.13 and Xp22.2-p22.32. Stroke 39: 1096–1102, https://doi.org/10.1161/strokeaha.107.495168.Search in Google Scholar

Samagh, N., Bhagat, H., and Jangra, K. (2019). Monitoring cerebral vasospasm: how much can we rely on transcranial Doppler. J. Anaesthesiol. Clin. Pharmacol. 35: 12–18, https://doi.org/10.4103/joacp.joacp_192_17.Search in Google Scholar PubMed PubMed Central

Santoro, A., Armocida, D., Paglia, F., Iacobucci, M., Berra, L.V., D’Angelo, L., Cirelli, C., Guidetti, G., Biraschi, F., and Cantore, G. (2022). Treatment of giant intracranial aneurysms: long-term outcomes in surgical versus endovascular management. Neurosurg. Rev. 45: 3759–3770, https://doi.org/10.1007/s10143-022-01884-3.Search in Google Scholar PubMed PubMed Central

Sathyan, S., Koshy, L.V., Balan, S., Easwer, H.V., Premkumar, S., Nair, S., Bhattacharya, R.N., Alapatt, J.P., and Banerjee, M. (2014). Association of Versican (VCAN) gene polymorphisms rs251124 and rs2287926 (G428D), with intracranial aneurysm. Meta Gene 2: 651–660, https://doi.org/10.1016/j.mgene.2014.07.001.Search in Google Scholar PubMed PubMed Central

Schubiger, O., Valavanis, A., and Wichmann, W. (1987). Growth-mechanism of giant intracranial aneurysms; demonstration by CT and MR imaging. Neuroradiology 29: 266–271, https://doi.org/10.1007/bf00451765.Search in Google Scholar

Sharma, B.S., Gupta, A., Ahmad, F.U., Suri, A., and Mehta, V.S. (2008). Surgical management of giant intracranial aneurysms. Clin. Neurol. Neurosurg. 110: 674–681, https://doi.org/10.1016/j.clineuro.2008.04.001.Search in Google Scholar PubMed

Sluzewski, M., Menovsky, T., van Rooij, W.J., and Wijnalda, D. (2003). Coiling of very large or giant cerebral aneurysms: long-term clinical and serial angiographic results. AJNR Am. J. Neuroradiol. 24: 257–262.Search in Google Scholar

Sorteberg, A. and Dahlberg, D. (2013). Intracranial non-traumatic aneurysms in children and adolescents. Curr. Pediatr. Rev. 9: 343–352, https://doi.org/10.2174/221155281120100005.Search in Google Scholar PubMed PubMed Central

Starke, R.M., Chalouhi, N., Ali, M.S., Jabbour, P.M., Tjoumakaris, S.I., Gonzalez, L.F., Rosenwasser, R.H., Koch, W.J., and Dumont, A.S. (2013). The role of oxidative stress in cerebral aneurysm formation and rupture. Curr. Neurovasc. Res. 10: 247–255, https://doi.org/10.2174/15672026113109990003.Search in Google Scholar PubMed PubMed Central

Stehbens, W.E. (1963). Histopathology of cerebral aneurysms. Arch. Neurol. 8: 272–285, https://doi.org/10.1001/archneur.1963.00460030056005.Search in Google Scholar PubMed

Sughrue, M.E., Saloner, D., Rayz, V.L., and Lawton, M.T. (2011). Giant intracranial aneurysms: evolution of management in a contemporary surgical series. Neurosurgery 69: 1261–1270, discussion 1270-1261, https://doi.org/10.1227/neu.0b013e31822bb8a6.Search in Google Scholar PubMed PubMed Central

Sugita, K. and Kobayashi, S. (1985). Microneurosurgical atlas. Springer, Heidelberg.10.1007/978-3-642-61669-3Search in Google Scholar

Suzuki, S., Takahashi, T., Ohkuma, H., Shimizu, T., and Fujita, S. (1992). Management of giant serpentine aneurysms of the middle cerebral artery – review of literature and report of a case successfully treated by STA-MCA anastomosis only. Acta Neurochir. 117: 23–29, https://doi.org/10.1007/bf01400630.Search in Google Scholar

Taufique, Z., May, T., Meyers, E., Falo, C., Mayer, S.A., Agarwal, S., Park, S., Connolly, E.S., Claassen, J., and Schmidt, J.M. (2016). Predictors of poor quality of life 1 Year after subarachnoid hemorrhage. Neurosurgery 78: 256–264, https://doi.org/10.1227/neu.0000000000001042.Search in Google Scholar

van der Schaaf, I.C., Brilstra, E.H., Buskens, E., and Rinkel, G.J. (2002). Endovascular treatment of aneurysms in the cavernous sinus: a systematic review on balloon occlusion of the parent vessel and embolization with coils. Stroke 33: 313–318, https://doi.org/10.1161/hs0102.101479.Search in Google Scholar PubMed

van Gijn, J. and Rinkel, G.J. (2001). Subarachnoid haemorrhage: diagnosis, causes and management. Brain 124: 249–278, https://doi.org/10.1093/brain/124.2.249.Search in Google Scholar PubMed

van Rooij, W.J. and Sluzewski, M. (2007). Coiling of very large and giant basilar tip aneurysms: midterm clinical and angiographic results. AJNR Am. J. Neuroradiol. 28: 1405–1408, https://doi.org/10.3174/ajnr.a0556.Search in Google Scholar PubMed PubMed Central

Vishteh, A.G. and Spetzler, R.F. (1999). Evolution of a dolichoectatic aneurysm into a giant serpentine aneurysm during long-term follow up. Case illustration. J. Neurosurg. 91: 346, https://doi.org/10.3171/jns.1999.91.2.0346.Search in Google Scholar PubMed

Wang, B., Gao, B.L., Xu, G.P., Xiang, C., and Liu, X.S. (2015). Endovascular embolization is applicable for large and giant intracranial aneurysms: experience in one center with long-term angiographic follow-up. Acta Radiol. 56: 105–113, https://doi.org/10.1177/0284185113520312.Search in Google Scholar PubMed

Wehman, J.C., Hanel, R.A., Levy, E.I., and Hopkins, L.N. (2006). Giant cerebral aneurysms: endovascular challenges. Neurosurgery 59: S125–S138, discussion S123-113, https://doi.org/10.1227/01.neu.0000237330.11482.90.Search in Google Scholar

Wessels, L., Hecht, N., Faust, K., Schneider, U., Czabanka, M., and Vajkoczy, P. (2021). Complete or partial parent artery sacrifice: effect of vessel-occlusion strategies on complete obliteration of complex aneurysms. World Neurosurg. 147: e282–e292, https://doi.org/10.1016/j.wneu.2020.12.050.Search in Google Scholar PubMed

Yan, P., Zhang, Y., Liang, F., Ma, C., Liang, S., Guo, F., and Jiang, C. (2019). Comparison of safety and effectiveness of endovascular treatments for unruptured intracranial large or giant aneurysms in internal carotid artery. World Neurosurg. 125: e385–e391, https://doi.org/10.1016/j.wneu.2019.01.082.Search in Google Scholar PubMed

Yasargil, M.G. (1984). Microneurosurgery, volume I: microsurgical Anatomy of the Basal Cisterns and Vessels of the brain, diagnostic studies, general operative Techniques and pathological Considerations of intracranial aneurysms. Thieme, Germany.Search in Google Scholar

Zheng, S., Su, A., Sun, H., and You, C. (2013). The association between interleukin-6 gene polymorphisms and intracranial aneurysms: a meta-analysis. Hum. Immunol. 74: 1679–1683, https://doi.org/10.1016/j.humimm.2013.08.274.Search in Google Scholar PubMed

Zhou, S., Dion, P.A., and Rouleau, G.A. (2018). Genetics of intracranial aneurysms. Stroke 49: 780–787, https://doi.org/10.1161/strokeaha.117.018152.Search in Google Scholar PubMed

Received: 2023-08-02
Accepted: 2023-12-08
Published Online: 2024-01-01
Published in Print: 2024-06-25

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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