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Current status of Guillain–Barré syndrome (GBS) in China: a 10-year comprehensive overview

  • Yanna Song , Xiaoxiao Zheng , Yong Fang , Shan Liu , Kangding Liu , Jie Zhu EMAIL logo and Xiujuan Wu ORCID logo EMAIL logo
Published/Copyright: May 8, 2023
Become an author with De Gruyter Brill

Abstract

Guillain–Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy; a disease involving the peripheral nervous system which is the most common cause of acute flaccid paralysis worldwide. So far, it is still lack of a comprehensive overview and understanding of the national epidemiological, clinical characteristics, and the risk factors of GBS in China, as well as differences between China and other countries and regions in these respects. With the global outbreak of the coronavirus disease 2019 (COVID-19), an epidemiological or phenotypic association between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and GBS has attracted great attention. In this review, we outlined the current clinical data of GBS in China by retrieving literature, extracting and synthesizing the data of GBS in China from 2010 to 2021. Besides, we compared the characteristics of epidemiology, preceding events and clinical profiles of GBS between China and other countries and regions. Furthermore, in addition to conventional intravenous immunoglobulin (IVIG) and plasma exchange (PE) therapy, the potential therapeutic effects with novel medications in GBS, such as complement inhibitors, etc., have become the research focus in treatments. We found that epidemiological and clinical findings of GBS in China are approximately consistent with those in the International GBS Outcome Study (IGOS) cohort. We provided an overall picture of the present clinical status of GBS in China and summarized the global research progress of GBS, aiming to further understand the characteristics of GBS and improve the future work of GBS worldwide, especially in countries with the middle and low incomes.


Corresponding authors: Jie Zhu, Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Xinmin Street 1, 130021 Changchun, China; and Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital, 17177 Solna, Stockholm, Sweden, E-mail: ; and Xiujuan Wu, Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Xinmin Street 1, 130021 Changchun, China, E-mail:
Yanna Song and Xiaoxiao Zheng are contributed equally to this work.

Acknowledgment

This work was supported by the project of The First hospital of Jilin University, Changchun city, Jilin Province, China.

  1. Author contribution: YS and XZ contributed equally to this work. YS and XW conceived the idea, revised all the literature, and wrote the manuscript. XZ, YF, KL, SL, and YS collected the clinical data. XW and YS analysis these data. XW and JZ contributed to the revision of the manuscript and read and approved the submitted version. All authors have read and approved the final manuscript.

  2. Research funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

  3. Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Received: 2023-02-27
Accepted: 2023-04-13
Published Online: 2023-05-08
Published in Print: 2023-12-15

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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