Abstract
Stroke is a major reason for disability and the second highest cause of death in the world. When a patient is admitted to a hospital, it is necessary to identify the type of stroke, and the likelihood for development of a recurrent stroke, vascular dementia, and depression. These factors could be determined using different biomarkers. Metabolomics is a very promising strategy for identification of biomarkers. The advantage of metabolomics, in contrast to other analytical techniques, resides in providing low molecular weight metabolite profiles, rather than individual molecule profiles. Technically, this approach is based on mass spectrometry and nuclear magnetic resonance. Furthermore, variations in metabolite concentrations during brain ischemia could alter the principal neuronal functions. Different markers associated with ischemic stroke in the brain have been identified including those contributing to risk, acute onset, and severity of this pathology. In the brain, experimental studies using the ischemia/reperfusion model (IRI) have shown an impaired energy and amino acid metabolism and confirmed their principal roles. Literature data provide a good basis for identifying markers of ischemic stroke and hemorrhagic stroke and understanding metabolic mechanisms of these diseases. This opens an avenue for the successful use of identified markers along with metabolomics technologies to develop fast and reliable diagnostic tools for ischemic and hemorrhagic stroke.
Funding source: Belarusian Republican Foundation for Fundamental Research
Award Identifier / Grant number: B19-001
Acknowledgments
We thank Mr. Randal Petlock, B.Sc., B.Ed. (Canada) and Ms. Natalla Liubetskaya for English language editing to improve the manuscript.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This work was supported by the Belorussian Republican Foundation of Basic Investigation (grant B19-001).
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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Articles in the same Issue
- Frontmatter
- Cell assembly formation and structure in a piriform cortex model
- Scoping review of the risk factors and time frame for development of post-traumatic hydrocephalus
- Triangle of cytokine storm, central nervous system involvement, and viral infection in COVID-19: the role of sFasL and neuropilin-1
- New insights into neural networks of error monitoring and clinical implications: a systematic review of ERP studies in neurological diseases
- Metabolomics and metabolites in ischemic stroke
- Post-stroke recrudescence—a possible connection to autoimmunity?
- Neuroplasticity mediated by motor rehabilitation in Parkinson’s disease: a systematic review on structural and functional MRI markers
Articles in the same Issue
- Frontmatter
- Cell assembly formation and structure in a piriform cortex model
- Scoping review of the risk factors and time frame for development of post-traumatic hydrocephalus
- Triangle of cytokine storm, central nervous system involvement, and viral infection in COVID-19: the role of sFasL and neuropilin-1
- New insights into neural networks of error monitoring and clinical implications: a systematic review of ERP studies in neurological diseases
- Metabolomics and metabolites in ischemic stroke
- Post-stroke recrudescence—a possible connection to autoimmunity?
- Neuroplasticity mediated by motor rehabilitation in Parkinson’s disease: a systematic review on structural and functional MRI markers