Training the brain: could it improve multiple sclerosis treatment?
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Berenice Anabel Silva
Dr Berenice Anabel Silva, MS, PhD , Neurologist of Multiple Sclerosis Clinic and Demyelinating Diseases. Ramos Mejía Hospital, University Centre of Neurology, School of Medicine. University of Buenos Aires, Argentina. Research field: Neuroscience. More than 40 publications in international journals. She studied the effect of cytokines in the brain in Multiple Sclerosis. During the last years, she developed pre-clinical model to study MS progressive lesions.Esteban Alberto Miglietta , Graduate student at the Faculty of Exact and Natural Sciences, University of Buenos Aires. Currently finishing his PhD thesis at the Laboratory of Protective and Regenerative Therapies of the Nervous System (Leloir Institute Foundation) with a fellowship from the National Research Council of Argentina (CONICET). Research field: Neuroscience. He studies the role of pathogenic mutations in the human LRRK2 protein as intermediaries of peripheral inflammation and neurodegeneration in the context of Parkinson's Disease in animal models.Dr Carina Cintia Ferrari, PhD , Research scientist of the National Research Council of Argentina (CONICET).Research field: Neuroscience. More than 40 publications in international journals. She studied the effect of cytokines in the brain in several neuroinflammatory disease (Parkison and Multiple sclerosis (MS). During the last years, she developed pre-clinical model to study MS progressive lesions.
Abstract
Multiple sclerosis (MS) is a neurological disease characterized by neuroinflammation, demyelination and axonal degeneration along with loss of function in the central nervous system. For many years, research in MS has focused on the efficacy of pharmacological treatments. However, during the last years, many publications have been dedicated to the study of the efficacy of non-pharmacological strategies, such as physical exercise and cognitive training. Beneficial effects of the combination of both strategies on cognitive function have been described in both ageing adults and patients with neurodegenerative diseases, such as MS. The analysis of combining both physical and cognitive stimulation can be summarized by the environmental enrichment (EE) experiments, which are more suitable for animal models. EE refers to housing conditions consisting of exercise and cognitive and social stimulation. In this review, we will summarize the available studies that describe the influence of EE in both MS patients and MS animal models.
Funding source: National Agency for Scientific and Technological Promotion (ANPCyT), Argentina
Award Identifier / Grant number: PICT-2012-0656
Funding source: Agencia Nacional de Promoción Científica y Tecnológica
Funding source: Consejo Nacional de Investigaciones Científicas y Técnicas
About the authors



Acknowledgments
This work was supported by the National Agency for Scientific and Technological Promotion (ANPCyT), Argentina, PICT-2012-0656 grant (CCF); the René Baron Foundation and Institute of Translational Medicine and Biomedical Engineering of the Italian Hospital (IMTIB, CONICET)
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This work was supported by the National Agency for Scientific and Technological Promotion (ANPCyT), Argentina, PICT-2012-0656 grant (CCF).
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19)
- Depression in post-traumatic stress disorder
- The continuum between neurodegeneration, brain plasticity, and movement: a critical appraisal
- The role of exosome lipids in central nervous system diseases
- Detection of disease-associated microRNAs — application for autism spectrum disorders
- The biological and diagnostic roles of MicroRNAs in meningiomas
- Training the brain: could it improve multiple sclerosis treatment?
- Treatment strategies for encephalopathy related to status epilepticus during slow sleep, a narrative review of the literature
Articles in the same Issue
- Frontmatter
- Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19)
- Depression in post-traumatic stress disorder
- The continuum between neurodegeneration, brain plasticity, and movement: a critical appraisal
- The role of exosome lipids in central nervous system diseases
- Detection of disease-associated microRNAs — application for autism spectrum disorders
- The biological and diagnostic roles of MicroRNAs in meningiomas
- Training the brain: could it improve multiple sclerosis treatment?
- Treatment strategies for encephalopathy related to status epilepticus during slow sleep, a narrative review of the literature