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The biological and diagnostic roles of MicroRNAs in meningiomas

  • Lei Wang EMAIL logo , Shengpan Chen , Yan Liu , Hongqi Zhang , Nianjun Ren , Ruoyu Ma and Zhengwen He EMAIL logo
Published/Copyright: July 22, 2020
Become an author with De Gruyter Brill

Abstract

MicroRNAs (miRNAs) refer to a class of small endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level. Emerging studies have shown that miRNAs play critical roles in tumorigenesis and cancer progression. However, roles and mechanisms of miRNA dysregulation in the pathogenesis of meningioma are not fully understood. Here, we first reviewed existing research of aberrantly expressed miRNAs identified by high throughput microarray profiling in meningioma. We also explored the potential of miRNA as biomarkers and therapeutic targets for novel treatment paradigms of meningiomas. In addition, we summarized recent researches that focused on the possible mechanisms involved in miRNA-mediate meningioma occurrence and progression. This review provides an overview of miRNA deregulation in meningioma and indicates the potential of miRNAs to be used as biomarkers or novel therapeutic targets.


Corresponding authors: Lei Wang, Department of Neurosurgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China, E-mail: ; and Zhengwen He, Department of Neurosurgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China, e-mail:

Funding source: National Key R&D Program of China

Award Identifier / Grant number: No.2018YFB1107103

Funding source: Hunan Provincial Natural Science Foundation of China

Award Identifier / Grant number: No.2019JJ40182

Funding source: Scientific Research Project of Hunan Provincial Health Commission

Award Identifier / Grant number: No.20200709

Funding source: China Postdoctoral Science Foundation

Award Identifier / Grant number: No.2019M660713

Funding source: Science Research Foundation of Hunan Provincial Education Department

Award Identifier / Grant number: No. 13B067

Funding source: Hunan Cancer Hospital Climb Plan

Award Identifier / Grant number: No.QH201906

Acknowledgements

This study was supported by the National Key R&D Program of China (No. 2018YFB1107103), Hunan Provincial Natural Science Foundation of China (No. 2019JJ40182), Scientific Research Project of Hunan Provincial Health Commission (No. 20200709), China Postdoctoral Science Foundation (No. 2019M660713), Science Research Foundation of Hunan Provincial Education Department (No. 13B067) and Hunan Cancer Hospital Climb Plan (No. QH201906).

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declare.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2020-04-11
Accepted: 2020-06-04
Published Online: 2020-07-22
Published in Print: 2020-10-25

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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