A brief essay on non-pharmacological treatment of Alzheimer’s disease

References

Ahmed, M.A., Darwish, E.S., Khedr, E.M., El Serogy, Y.M., and Ali, A.M. (2012). Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer’s dementia. J. Neurol. 259, 83–92.10.1007/s00415-011-6128-4Search in Google Scholar PubMed

Allain, P., Foloppe, D.A., Besnard, J., Yamaguchi, T., Etcharry-Bouyx, F., Le Gall, D., Nolin, P., and Richard, P. (2014). Detecting everyday action deficits in Alzheimer’s disease using a nonimmersive virtual reality kitchen. J. Int. Neuropsychol. Soc. 20, 468–477.10.1017/S1355617714000344Search in Google Scholar PubMed

Anguera, J.A., Boccanfuso, J., Rintoul, J.L., Al-Hashimi, O., Faraji, F., Janowich, J., Kong, E., Larraburo, Y., Rolle, C., Johnston, E., et al. (2013). Video game training enhances cognitive control in older adults. Nature 501, 97–101.10.1038/nature12486Search in Google Scholar PubMed PubMed Central

Arrieta-Cruz, I., Pavlides, C., and Pasinetti, G.M. (2010). Deep brain stimulation in the midline thalamic region facilitates short-term memory in a mouse model of Alzheimer’s disease. Transl. Neurosci. 1, 188–194.10.2478/v10134-010-0023-xSearch in Google Scholar PubMed PubMed Central

Avila, R., Bottino, C.M., Carvalho, I.A., Santos, C.B., Seral, C., and Miotto, E.C. (2004). Neuropsychological rehabilitation of memory deficits and activities of daily living in patients with Alzheimer’s disease: a pilot study. Braz. J. Med. Biol. Res. 37, 1721–1729.10.1590/S0100-879X2004001100018Search in Google Scholar

Baglio, F., Griffanti, L., Saibene, F.L., Ricci, C., Alberoni, M., Critelli, R., Villanelli, F., Fioravanti, R., Mantovani, F., D’amico, A., et al. (2015). Multistimulation group therapy in Alzheimer’s disease promotes changes in brain functioning. Neurorehabil. Neural Repair. 29, 13–24.10.1177/1545968314532833Search in Google Scholar PubMed

Bahar-Fuchs, A., Clare, L., and Woods, B. (2013). Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer’s disease and vascular dementia. Cochrane Database Syst. Rev. 5, CD003260.10.1002/14651858.CD003260.pub2Search in Google Scholar PubMed PubMed Central

Bailey, R.A. (2008). Design of comparative experiments (Cambridge: Cambridge University Press).Search in Google Scholar

Bentwich, J., Dobronevsky, E., Aichenbaum, S., Shorer, R., Peretz, R., Khaigrekht, M., Marton, R.G., and Rabey, J.M. (2011). Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer’s disease: a proof of concept study. J. Neural. Transm. (Vienna) 118, 463–471.10.1007/s00702-010-0578-1Search in Google Scholar PubMed

Boggio, P.S., Khoury, L.P., Martins, D.C., Martins, O.E., de Macedo, E.C., and Fregni, F. (2009). Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease. J. Neurol. Neurosurg. Psychiatry 80, 444–447.10.1136/jnnp.2007.141853Search in Google Scholar PubMed

Boggio, P.S., Ferrucci, R., Mameli, F., Martins, D., Martins, O., Vergari, M., Tadini, L., Scarpini, E., Fregni, F., and Priori, A. (2012). Prolonged visual memory enhancement after direct current stimulation in Alzheimer’s disease. Brain Stimul. 5, 223–230.10.1016/j.brs.2011.06.006Search in Google Scholar PubMed

Bohil, C.J., Alicea, B., and Biocca, F.A. (2011). Virtual reality in neuroscience research and therapy. Nat. Rev. Neurosci. 12, 752–762.10.1038/nrn3122Search in Google Scholar PubMed

Burdea, G.C. (2003a). Virtual Rehabilitation – benefits and challenges. Yearb. Med. Inform. 1, 170176.Search in Google Scholar

Burdea, G.C. (2003b). Virtual rehabilitation – benefits and challenges. Methods Inf. Med. 42, 519–523.10.1055/s-0038-1634378Search in Google Scholar

Burdea, G.C. and Coiffet, P. (2003). Virtual Reality Technology, 2nd ed. (New York, NY: Wiley).10.1162/105474603322955950Search in Google Scholar

Burke, W.H., Zencius, A.H., Wesolowski, M.D., and Doubleday, F. (1991). Improving executive function disorders in brain-injured clients. Brain Inj. 5, 241–252.10.3109/02699059109008095Search in Google Scholar PubMed

Cantone, M., Di Pino, G., Capone, F., Piombo, M., Chiarello, D., Cheeran, B., Pennisi, G., and Di Lazzaro, V. (2014). The contribution of transcranial magnetic stimulation in the diagnosis and in the management of dementia. Clin. Neurophysiol. 125, 1509–1532.10.1016/j.clinph.2014.04.010Search in Google Scholar PubMed

Cicerone, K.D., Dahlberg, C., Malec, J.F., Langenbahn, D.M., Felicetti, T., Kneipp, S., Ellmo, W., Kalmar, K., Giacino, J.T., Harley, J.P., et al. (2005). Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch. Phys. Med. Rehabil. 86, 1681–1692.10.1016/j.apmr.2005.03.024Search in Google Scholar PubMed

Clare, L. and Woods, B. (2004). Cognitive training and cognitive rehabilitation for people with early-stage Alzheimer’s disease: a review. Neuropsychol. Rehabil. 14, 385–401.10.1080/09602010443000074Search in Google Scholar

Cotelli, M., Manenti, R., Cappa, S.F., Geroldi, C., Zanetti, O., Rossini, P.M., and Miniussi, C. (2006). Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease. Arch. Neurol. 63, 1602–1604.10.1001/archneur.63.11.1602Search in Google Scholar PubMed

Cotelli, M., Manenti, R., Cappa, S.F., Zanetti, O., and Miniussi, C. (2008). Transcranial magnetic stimulation improves naming in Alzheimer disease patients at different stages of cognitive decline. Eur. J. Neurol. 15, 1286–1292.10.1111/j.1468-1331.2008.02202.xSearch in Google Scholar PubMed

Cotelli, M., Manentil, R., Rosini, S., Brambilla, M., Zanetti, O., and Miniussi, C. (2010). Brain stimulation in Alzheimer disease. Neuropsychol. Trends 8, 57–60.Search in Google Scholar

Cotelli, M., Calabria, M., Manenti, R., Rosini, S., Zanetti, O., Cappa, S.F., and Miniussi, C. (2011). Improved language performance in Alzheimer disease following brain stimulation. J. Neurol. Neurosurg. Psychiatry 82, 794–797.10.1136/jnnp.2009.197848Search in Google Scholar PubMed

Coyle, H., Traynor, V., and Solowij, N. (2015). Computerized and virtual reality cognitive training for individuals at high risk of cognitive decline: systematic review of the literature. Am. J. Geriatr. Psychiatry 23, 335–359.10.1016/j.jagp.2014.04.009Search in Google Scholar PubMed

Devi, G., Voss, H.U., Levine, D., Abrassart, D., Heier, L., Halper, J., Martin, L., and Lowe, S. (2014). Open-label, short-term, repetitive transcranial magnetic stimulation in patients with Alzheimer’s disease with functional imaging correlates and literature review. Am. J. Alzheimers Dis. Other Demen. 29, 248–255.10.1177/1533317513517047Search in Google Scholar PubMed

Elder, G.J. and Taylor, J.P. (2014). Transcranial magnetic stimulation and transcranial direct current stimulation: treatments for cognitive and neuropsychiatric symptoms in the neurodegenerative dementias? Alzheimers Res. Ther. 6, 74.10.1186/s13195-014-0074-1Search in Google Scholar PubMed PubMed Central

Ferrucci, R., Mameli, F., Guidi, I., Mrakic-Sposta, S., Vergari, M., Marceglia, S., Cogiamanian, F., Barbieri, S., Scarpini, E., and Priori, A. (2008). Transcranial direct current stimulation improves recognition memory in Alzheimer disease. Neurology 71, 493–498.10.1212/01.wnl.0000317060.43722.a3Search in Google Scholar PubMed

Folsom, J.C. (1967). Intensive hospital therapy of geriatric patients. Curr. Psychiatr Ther. 7, 209–215.Search in Google Scholar

Folstein, M.F., Folstein, S.E., and McHugh, P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12, 189–198.10.1016/0022-3956(75)90026-6Search in Google Scholar PubMed

García-Betances, R.I., Arredondo Waldmeyer, M.T., Fico, G., and Cabrera-Umpiérrez, M.F. (2015). A succinct overview of virtual reality technology use in Alzheimer’s disease. Front. Aging Neurosci. 7, 80.10.3389/fnagi.2015.00080Search in Google Scholar PubMed PubMed Central

Grieve, S.M., Williams, L.M., Paul, R.H., Clark, C.R., and Gordon, E. (2007). Cognitive aging, executive function, and fractional anisotropy: a diffusion tensor MR imaging study. Am. J. Neuroradiol. 28, 226–235.Search in Google Scholar

Hallett, M. (2007). Transcranial magnetic stimulation: a primer. Neuron 55, 187–199.10.1016/j.neuron.2007.06.026Search in Google Scholar PubMed

Hamani, C., Stone, S.S., Garten, A., Lozano, A.M., and Winocur, G. (2011). Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone. Exp Neurol. 232, 100–104.10.1016/j.expneurol.2011.08.023Search in Google Scholar PubMed

Hammond, C., Ammari, R., Bioulac, B., and Garcia, L. (2008). Latest view on the mechanism of action of deep brain stimulation. Mov. Disord. 23, 2111–2121.10.1002/mds.22120Search in Google Scholar PubMed

Hedges, L.V. and Olkin, I. (1985). Statistical Methods for Meta-analysis (New York: Academic Press).Search in Google Scholar

Hill, N.T., Mowszowski, L., Naismith, S.L., Chadwick, V.L., Valenzuela, M., and Lampit, A. (2017). Computerized cognitive training in older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis. Am. J. Psychiatry. 174, 329–340.10.1176/appi.ajp.2016.16030360Search in Google Scholar PubMed

Hoeppner, J., Wegrzyn, M., Thome, J., Bauer, A., Oltmann, I., Buchmann, J., and Teipel, S. (2012). Intra- and inter-cortical motor excitability in Alzheimer’s disease. J. Neural. Transm. (Vienna) 119, 605–612.10.1007/s00702-011-0738-ySearch in Google Scholar PubMed

Huntley, J.D., Gould, R.L., Liu, K., Smith, M., and Howard, R.J. (2015). Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression. BMJ Open 5, e005247.10.1136/bmjopen-2014-005247Search in Google Scholar PubMed PubMed Central

Ibarria, M., Alegret, M., Valero, S., Morera, A., Guitart, M., Cañabate, P., Moreno, M., Lara, S., Diego, S., Hernández, J., et al. (2016). Beneficial effects of an integrated psychostimulation program in patients with Alzheimer’s disease. J. Alzheimers Dis. 50, 559–566.10.3233/JAD-150455Search in Google Scholar PubMed PubMed Central

Khedr, E.M., Rothwell, J.C., Shawky, O.A., Ahmed, M.A., and Hamdy, A. (2006). Effect of daily repetitive transcranial magnetic stimulation on motor performance in Parkinson’s disease. Mov. Disord. 21, 2201–2205.10.1002/mds.21089Search in Google Scholar PubMed

Kimbrell, T.A., Dunn, R.T., George, M.S., Danielson, A.L., Willis, M.W., Repella, J.D., Benson, B.E., Herscovitch, P., Post, R.M., and Wassermann, E.M. (2002). Left prefrontal-repetitive transcranial magnetic stimulation (rTMS) and regional cerebral glucose metabolism in normal volunteers. Psychiatry Res. 115, 101–113.10.1016/S0925-4927(02)00041-0Search in Google Scholar PubMed

Kuhn, J., Hardenacke, K., Lenartz, D., Gruendler, T., Ullsperger, M., Bartsch, C., Mai, J.K., Zilles, K., Bauer, A., Matusch, A., et al. (2015). Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia. Mol. Psychiatry 20, 353–360.10.1038/mp.2014.32Search in Google Scholar PubMed

Laxton, A.W. and Lozano, A.M. (2013). Deep brain stimulation for the treatment of Alzheimer disease and dementias. World Neurosurg. 80, S28.e1–S28.e8.10.1016/j.wneu.2012.06.028Search in Google Scholar PubMed

Laxton, A.W., Tang-Wai, D.F., McAndrews, M.P., Zumsteg, D., Wennberg, R., Keren, R., Wherrett, J., Naglie, G., Hamani, C., Smith, G.S., et al. (2010). A phase I trial of deep brain stimulation of memory circuits in Alzheimer’s disease. Ann. Neurol. 68, 521–534.10.1002/ana.22089Search in Google Scholar PubMed

Lewis, M.I. and Butler, R.N. (1974). Life-review therapy. Putting memories to work in individual and group psychotherapy. Geriatrics 29, 165–173.Search in Google Scholar

Livingston, G., Kelly, L., Lewis-Holmes, E., Bai, G., Morris, S., Patel, N., Omar, R.Z., Katona, C., and Cooper, C. (2014). A systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementia. Health Technol. Assess. 18, 1–226.10.3310/hta18390Search in Google Scholar PubMed PubMed Central

Marras, A. and Pallanti, S. (2013). Transcranial magnetic stimulation for the treatment of pharmacoresistant nondelusional auditory verbal hallucinations in dementia. Case Rep. Psychiatry 2013, 930304.10.1155/2013/930304Search in Google Scholar PubMed PubMed Central

Monai, H., Ohkura, M., Tanaka, M., Oe, Y., Konno, A., Hirai, H., Mikoshiba, K., Itohara, S., Nakai, J., Iwai, Y., et al. (2016). Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain. Nat. Commun. 7, 11100.10.1038/ncomms11100Search in Google Scholar PubMed PubMed Central

Nitsche, M.A. and Paulus, W. (2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J. Physiol. 527, 633–639.10.1111/j.1469-7793.2000.t01-1-00633.xSearch in Google Scholar PubMed PubMed Central

Nitsche, M.A., Cohen, L.G., Wassermann, E.M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P.S., Fregni, F., et al. (2008). Transcranial direct current stimulation: state of the art 2008. Brain Stimul. 1, 206–223.10.1016/j.brs.2008.06.004Search in Google Scholar PubMed

O’Keefe, J. and Nadel, L. (1978). The Hippocampus as Cognitive Map (Oxford: Oxford University Press).Search in Google Scholar

Olazarán, J., Muñiz, R., Reisberg, B., Peña-Casanova, J., del Ser, T., Cruz-Jentoft, A.J., Serrano, P., Navarro, E., García de la Rocha, M.L., Frank, A., et al. (2004). Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. Neurology 63, 2348–2353.10.1212/01.WNL.0000147478.03911.28Search in Google Scholar PubMed

Optale, G., Urgesi, C., Busato, V., Marin, S., Piron, L., Priftis, K., Gamberini, L., Capodieci, S., and Bordin, A. (2010). Controlling memory impairment in elderly adults using virtual reality memory training: a randomized controlled pilot study. Neurorehabil. Neural Repair 24, 348–357.10.1177/1545968309353328Search in Google Scholar PubMed

Orgeta, V., Qazi, A., Spector, A.E., and Orrell, M. (2014). Psychological treatments for depression and anxiety in dementia and mild cognitive impairment. Cochrane Database Syst. Rev. 1, CD009125.10.1002/14651858.CD009125.pub2Search in Google Scholar PubMed PubMed Central

Orgeta, V., Leung, P., Yates, L., Kang, S., Hoare, Z., Henderson, C., Whitaker, C., Burns, A., Knapp, M., Leroi, I., et al. (2015). Individual cognitive stimulation therapy for dementia: a clinical effectiveness and cost-effectiveness pragmatic, multicentre, randomised controlled trial. Health Technol. Assess. 19, 1–108.10.3310/hta19640Search in Google Scholar PubMed PubMed Central

Orrell, M., Spector, A., Thorgrimsen, L., and Woods, B. (2005). A pilot study examining the effectiveness of maintenance cognitive stimulation therapy (MCST) for people with dementia. Int. J. Geriatr. Psychiatry 20, 446–451.10.1002/gps.1304Search in Google Scholar PubMed

Ovadia, D. and Bottini, G. (2015). Neuroethical implications of deep brain stimulation in degenerative disorders. Curr. Opin. Neurol. 28, 598–603.10.1097/WCO.0000000000000263Search in Google Scholar PubMed

Panerai, S., Tasca, D., Musso, S., Catania, V., Ruggeri, F., Raggi, A., Muratore, S., Prestianni, G., Bonforte, C., and Ferri, R. (2016). Group intensive cognitive activation in patients with major or mild neurocognitive disorder. Front. Behav. Neurosci. 10, 34.10.3389/fnbeh.2016.00034Search in Google Scholar PubMed PubMed Central

Pereira, J.L., Downes, A., Gorgulho, A., Patel, V., Malkasian, D., and De Salles, A. (2014). Alzheimer’s disease: the role for neurosurgery. Surg. Neurol. Int. 5, S385–S390.10.4103/2152-7806.140191Search in Google Scholar PubMed PubMed Central

Phung, K.T., Waldorff, F.B., Buss, D.V., Eckermann, A., Keiding, N., Rishøj, S., Siersma, V., Sørensen, J., Søgaard, R., Sørensen, L.V., et al. (2013). A three-year follow-up on the efficacy of psychosocial interventions for patients with mild dementia and their caregivers: the multicentre, rater-blinded, randomised Danish Alzheimer Intervention Study (DAISY). BMJ Open 3, e003584.10.1136/bmjopen-2013-003584Search in Google Scholar PubMed PubMed Central

Pievani, M., Pini, L., Cappa, S.F., and Frisoni, G.B. (2016). Brain networks stimulation in dementia: insights from functional imaging. Curr. Opin. Neurol. 29, 756–762.10.1097/WCO.0000000000000387Search in Google Scholar PubMed

Pikhovych, A., Stolberg, N.P., Jessica Flitsch, L., Walter, H.L., Graf, R., Fink, G.R., Schroeter, M., and Rueger, M.A. (2016). Transcranial direct current stimulation modulates neurogenesis and microglia activation in the mouse brain. Stem Cells Int. 2016, 2715196.10.1155/2016/2715196Search in Google Scholar PubMed PubMed Central

Pitkälä, K.H., Pöysti, M.M., Laakkonen, M.L., Tilvis, R.S., Savikko, N., Kautiainen, H., and Strandberg, T.E. (2013). Effects of the Finnish Alzheimer disease exercise trial (FINALEX): a randomized controlled trial. J. Am. Med. Assoc. Intern. Med. 173, 894–901.10.1001/jamainternmed.2013.359Search in Google Scholar PubMed

Ponce, F.A., Asaad, W.F., Foote, K.D., Anderson, W.S., Rees Cosgrove, G., Baltuch, G.H., Beasley, K., Reymers, D.E., Oh, E.S., Targum, S.D., et al.; for the Advance Research Group. (2016). Bilateral deep brain stimulation of the fornix for Alzheimer’s disease: surgical safety in the Advance Trial. J Neurosurg. 125, 75–84.10.3171/2015.6.JNS15716Search in Google Scholar PubMed PubMed Central

Poulton, J.L. and Strassberg, D.S. (1986). The therapeutic use of reminiscence. Int. J. Group Psychother. 36, 381–398.10.1080/00207284.1986.11490910Search in Google Scholar PubMed

Rabey, J.M., Dobronevsky, E., Aichenbaum, S., Gonen, O., Marton, R.G., and Khaigrekht, M. (2013). Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer’s disease: a randomized, double-blind study. J. Neural. Transm. 120, 813–819.10.1007/s00702-012-0902-zSearch in Google Scholar PubMed

Raggi, A., Iannaccone, S., Marcone, A., Ginex, V., Ortelli, P., Nonis, A., Giusti, M.C., and Cappa, S.F. (2007). The effects of a comprehensive rehabilitation program of Alzheimer’s disease in a hospital setting. Behav. Neurol. 18, 1–6.10.1155/2007/782959Search in Google Scholar PubMed PubMed Central

Raggi, A., Tasca, D., Panerai, S., Neri, W., and Ferri, R. (2015). The burden of distress and related coping processes in family caregivers of patients with Alzheimer’s disease living in the community. J. Neurol. Sci. 358, 77–81.10.1016/j.jns.2015.08.024Search in Google Scholar PubMed

Rosen, W.G., Mohs, R.C., and Davis, K.L. (1984). A new rating scale for Alzheimer’s disease. Am. J. Psychiatry 141, 1356–1364.10.1176/ajp.141.11.1356Search in Google Scholar PubMed

Rossi, S., Hallett, M., Rossini, P.M., and Pascual-Leone, A. (2009). Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin. Neurophysiol. 120, 2008–2039.10.1016/j.clinph.2009.08.016Search in Google Scholar PubMed PubMed Central

Rus-Calafell, M., Gutiérrez-Maldonado, J., and Ribas-Sabaté, J. (2014). A virtual reality-integrated program for improving social skills in patients with schizophrenia: a pilot study. J. Behav. Ther. Exp. Psychiatry. 45, 81–89.10.1016/j.jbtep.2013.09.002Search in Google Scholar PubMed

Rutherford, G., Lithgow, B., and Moussavi, Z. (2015). Short and long-term effects of rTMS treatment on Alzheimer’s disease at different stages: a pilot study. J. Exp. Neurosci. 9, 43–51.10.4137/JEN.S24004Search in Google Scholar PubMed PubMed Central

Serino, S. and Riva, G. (2013). Getting lost in Alzheimer’s disease: a break in the mental frame syncing. Med. Hypotheses 80, 416–421.10.1016/j.mehy.2012.12.031Search in Google Scholar PubMed

Serino, S., Morganti, F., Di Stefano, F., and Riva, G. (2015). Detecting early egocentric and allocentric impairments deficits in Alzheimer’s disease: an experimental study with virtual reality. Front Aging Neurosci. 7, 88.10.3389/fnagi.2015.00088Search in Google Scholar PubMed PubMed Central

Sevigny, J., Chiao, P., Bussière, T., Weinreb, P.H., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y., et al. (2016). The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature 537, 50–56.10.1038/nature19323Search in Google Scholar PubMed

Smith, G.S., Laxton, A.W., Tang-Wai, D.F., McAndrews, M.P., Diaconescu, A.O., Workman, C.I., and Lozano, A.M. (2012). Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease. Arch. Neurol. 69, 1141–1148.10.1001/archneurol.2012.590Search in Google Scholar PubMed

Sparing, R. and Mottaghy, F.M. (2008). Noninvasive brain stimulation with transcranial magnetic or direct current stimulation (TMS/tDCS) – from insights into human memory to therapy of its dysfunction. Methods 44, 329–337.10.1016/j.ymeth.2007.02.001Search in Google Scholar PubMed

Spector, A., Orrell, M., Davies, S., and Woods, B. (2001). Can reality orientation be rehabilitated? Development and piloting of an evidence based programme of cognition-based therapies for people with dementia. Neuropsychol. Rehabil. 11, 377–397.10.1080/09602010143000068Search in Google Scholar

Spector, A., Thorgrimsen, L., Woods, B., Royan, L., Davies, S., Butterworth, M., and Orrell, M. (2003). Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. Br. J. Psychiatry 183, 248–254.10.1192/bjp.183.3.248Search in Google Scholar PubMed

Stigler, S.M. (1992). A historical view of statistical concepts in psychology and educational research. Am. J. Educ. (Chic Ill). 10, 60–70.10.1086/444032Search in Google Scholar

Strøm, B.S., Ytrehus, S., and Grov, E.K. (2016). Sensory stimulation for persons with dementia: a review of the literature. J. Clin. Nurs. 25, 1805–1834.10.1111/jocn.13169Search in Google Scholar PubMed

Suemoto, C.K., Apolinario, D., Nakamura-Palacios, E.M., Lopes, L., Leite, R.E., Sales, M.C., Nitrini, R., Brucki, S.M., Morillo, L.S., Magaldi, R.M., et al. (2014). Effects of a non-focal plasticity protocol on apathy in moderate Alzheimer’s disease: a randomized, double-blind, sham-controlled trial. Brain Stimul. 7, 308–313.10.1016/j.brs.2013.10.003Search in Google Scholar PubMed

Taffou, M., Guerchouche, R., Drettakis, G., and Viaud-Delmon, I. (2013). Auditory-visual aversive stimuli modulate the conscious experience of fear. Multisens. Res. 26, 347–370.10.1163/22134808-00002424Search in Google Scholar

Talassi, E., Guerreschi, M., Feriani, M., Fedi, V., Bianchetti, A., and Trabucchi, M. (2007). Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): a case control study. Arch. Gerontol. Geriatr. 44, 391–399.10.1016/j.archger.2007.01.055Search in Google Scholar PubMed

Tarnanas, I., Tsolaki, M., Nef, T., Müri, R.M., and Mosimann, U.P. (2014). Can a novel computerized cognitive screening test provide additional information for early detection of Alzheimer’s disease? Alzheimers Dement. 10, 790–798.10.1016/j.jalz.2014.01.002Search in Google Scholar PubMed

Tarnanas, I., Tsolaki, A., Wiederhold, M., Wiederhold, B., and Tsolaki, M. (2015). Five-year biomarker progression variability for Alzheimer’s disease dementia prediction: can a complex instrumental activities of daily living marker fill in the gaps? Alzheimers Dement (Amst). 1, 521–532.10.1016/j.dadm.2015.10.005Search in Google Scholar PubMed PubMed Central

Taulbee, L.R. and Folsom, J.C. (1966). Reality orientation for geriatric patients. Hosp. Community Psychiatry 17, 133–135.10.1176/ps.17.5.133Search in Google Scholar PubMed

Tierney, T.S., Vasudeva, V.S., Weir, S., and Hayes M.T. (2013). Neuromodulation for neurodegenerative conditions. Front. Biosci. (Elite Ed) 5, 490–499.10.2741/E630Search in Google Scholar PubMed

Turnbull, I.M., McGeer, P.L., Beattie, L., Calne, D., and Pate, B. (1985). Stimulation of the basal nucleus of Meynert in senile dementia of Alzheimer’s type. A preliminary report. Appl. Neurophysiol. 48, 216–221.10.1159/000101130Search in Google Scholar

Turriziani, P., Smirni, D., Zappalà, G., Mangano, G.R., Oliveri, M, and Cipolotti, L. (2012). Enhancing memory performance with rTMS in healthy subjects and individuals with mild cognitive impairment: the role of the right dorsolateral prefrontal cortex. Front. Hum. Neurosci. 6, 62.10.3389/fnhum.2012.00062Search in Google Scholar PubMed PubMed Central

Ueyama, E., Ukai, S., Ogawa, A., Yamamoto, M., Kawaguchi, S., Ishii, R., and Shinosaki, K. (2011). Chronic repetitive transcranial magnetic stimulation increases hippocampal neurogenesis in rats. Psychiatry Clin. Neurosci. 65, 77–81.10.1111/j.1440-1819.2010.02170.xSearch in Google Scholar PubMed

Van Paasschen, J., Clare L., Yuen, K.S., Woods, R.T., Evans, S.J., Parkinson, C.H., Rugg, M.D., and Linden, D.E. (2013). Cognitive rehabilitation changes memory-related brain activity in people with Alzheimer disease. Neurorehabil. Neural Repair 27, 448–459.10.1177/1545968312471902Search in Google Scholar PubMed

Van Schaik, P., Martyr, A., Blackman, T., and Robinson, J. (2008). Involving persons with dementia in the evaluation of outdoor environments. Cyberpsychol. Behav. 11, 415–424.10.1089/cpb.2007.0105Search in Google Scholar PubMed

Volkmann, J. (2004). Deep brain stimulation for the treatment of Parkinson’s disease. J Clin. Neurophysiol. 21, 6–17.10.1097/00004691-200401000-00003Search in Google Scholar PubMed

Waite, L.M. (2015). Treatment for Alzheimer’s disease: has anything changed? Aust. Prescr. 38, 60–63.10.18773/austprescr.2015.018Search in Google Scholar PubMed PubMed Central

Wald, J. and Taylor, S. (2000). Efficacy of virtual reality exposure therapy to treat driving phobia: a case report. J. Behav. Ther. Exp. Psychiatry 31, 249–257.10.1016/S0005-7916(01)00009-XSearch in Google Scholar

Yates, L.A., Leung, P., Orgeta, V., Spector, A., and Orrell, M. (2014). The development of individual cognitive stimulation therapy (iCST) for dementia. Clin. Interv. Aging 10, 95–104.10.2147/CIA.S73844Search in Google Scholar PubMed PubMed Central

Yoon, K.J., Lee, Y.T., and Han, T.R. (2011). Mechanism of functional recovery after repetitive transcranial magnetic stimulation (rTMS) in the subacute cerebral ischemic rat model: neural plasticity or anti-apoptosis? Exp. Brain Res. 214, 549–556.10.1007/s00221-011-2853-2Search in Google Scholar PubMed

Yun, K., Song, I.U., and Chung, Y.A. (2016). Changes in cerebral glucose metabolism after 3 weeks of noninvasive electrical stimulation of mild cognitive impairment patients. Alzheimers Res. Ther. 8, 49.10.1186/s13195-016-0218-6Search in Google Scholar PubMed PubMed Central

Zucchella, C., Bartolo, M., Bernini, S., Picascia, M., and Sinforiani, E. (2015). Quality of life in Alzheimer disease: a comparison of patients’ and caregivers’ points of view. Alzheimer Dis. Assoc. Disord. 29, 50–54.10.1097/WAD.0000000000000050Search in Google Scholar PubMed