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Epilepsy and vitamin D: a comprehensive review of current knowledge

  • Seyed Amir Miratashi Yazdi , Mehdi Abbasi EMAIL logo and Seyed Masoud Miratashi Yazdi
Published/Copyright: December 19, 2016
Become an author with De Gruyter Brill

Abstract

Vitamin D has been considered as neurosteroid, and its pivotal role in neuroprotection, brain development, and immunomodulation has been noticed in studies; however, our knowledge regarding its role in neurological disorders is still developing. The potential role of vitamin D in the pathophysiology and treatment of epilepsy, as one the most prevalent neurological disorders, has received less attention in recent years. In this article, we review the possible relationship between vitamin D and epilepsy from different aspects, including the action mechanism of vitamin D in the central nervous system and ecological and epidemiological findings. We also present the outcome of studies that evaluated the level of vitamin D and the impact of administrating vitamin D in epileptic patients or animal subjects. We also review the current evidence on interactions between vitamin D and antiepileptic drugs.

  1. Conflict of interest statement: All authors declare that they have no conflict of interest.

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Received: 2016-7-21
Accepted: 2016-9-24
Published Online: 2016-12-19
Published in Print: 2017-2-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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