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Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes

  • Lan Huang , Fengyan Zhao , Yi Qu , Li Zhang , Yan Wang and Dezhi Mu EMAIL logo
Published/Copyright: August 25, 2016
Become an author with De Gruyter Brill

Abstract

Hypoxic-ischemic encephalopathy (HIE), a serious disease leading to neonatal death, is becoming a key area of pediatric neurological research. Despite remarkable advances in the understanding of HIE, the explicit pathogenesis of HIE is unclear, and well-established treatments are absent. Animal models are usually considered as the first step in the exploration of the underlying disease and in evaluating promising therapeutic interventions. Various animal models of HIE have been developed with distinct characteristics, and it is important to choose an appropriate animal model according to the experimental objectives. Generally, small animal models may be more suitable for exploring the mechanisms of HIE, whereas large animal models are better for translational studies. This review focuses on the features of commonly used HIE animal models with respect to their modeling strategies, merits, and shortcomings, and associated neuropathological changes, providing a comprehensive reference for improving existing animal models and developing new animal models.

Acknowledgments

This work was supported by the National Science Foundation of China (grant numbers 81330016 and 81270724), the Major State Basic Research Development Program (2013CB967404 and 2012BAl04B00), a grant from the Ministry of Education of China (IRT0935), grants from the Science and Technology Bureau of Sichuan province (2014SZ0149 and 2016TD0002), and a grant of the Clinical Discipline Program (Neonatology) from the Ministry of Health of China (1311200003303).

  1. Conflict of interest statement: The authors declare that they have no conflict of interest.

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Received: 2016-4-27
Accepted: 2016-7-15
Published Online: 2016-8-25
Published in Print: 2017-1-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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