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Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis

  • Amene Saghazadeh , Maryam Gharedaghi , Alipasha Meysamie , Sebastian Bauer and Nima Rezaei EMAIL logo
Published/Copyright: February 7, 2014
Become an author with De Gruyter Brill

Abstract

Activation of proinflammatory and anti-inflammatory cytokines network seems to have a role in febrile seizures (FS). The present meta-analysis was aimed to pool the inconsistent data provided with case-control studies on the relationship of proinflammatory and anti-inflammatory cytokines and FS/epilepsy risk. The genotype interleukin (IL)-1α-889 1/1 (recessive model) was significantly correlated with increased risk of epilepsy (p=0.008) and FS/epilepsy (p=0.004). Patients with IL-1β-511 T/T homozygote were more susceptible to develop FS (p=0.036) but not epilepsy. Furthermore, the T/T genotype was totally associated with increased risk of FS/epilepsy (p=0.043). Although the recessive model was also confirmed for the Asian subgroup (FS and FS/epilepsy), we found a protective effect of C/C genotype toward developing FS in the Caucasian race (p=0.020). The second meta-analysis on cytokine levels showed a statistically higher serum level of IL-6 in patients with epilepsy compared to control subjects without epilepsy. The present meta-analysis showed that two alleles of proinflammatory cytokines (IL-1α-889 and IL-1β-511) in addition to the serum concentration of IL-6 were significantly associated with FS and epilepsy or both in various subgroup analyses.


Corresponding author: Nima Rezaei, Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Dr. Qarib Street, Keshavarz Boulevard, Tehran 14194, Iran, e-mail: ; Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran 14194, Iran; and Department of Infection and Immunity, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, S10 2TN, UK

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Received: 2013-10-20
Accepted: 2013-12-26
Published Online: 2014-2-7
Published in Print: 2014-4-1

©2014 by Walter de Gruyter Berlin/Boston

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