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Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia

  • Ulrike Richter EMAIL logo , Pär Halje and Per Petersson
Published/Copyright: August 2, 2013
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Abstract

A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies.


Corresponding author: Ulrike Richter, Integrative Neurophysiology and Neurotechnology, Neuroanano Research Center, Department of Experimental Medical Sciences, Lund University, BMC F10, S-221 84 Lund, Sweden

This work has been funded by: The Swedish Research Council [#325-2011-6441], Stiftelsen Olle Engkvist Byggmästare, The Parkinson Research Foundation, The Michael J Fox Foundation and Åke Wibergs Stiftelse. We would like to thank Martin Tamtè and Nedjeljka Ivica for comments on this manuscript, and we are thankful for the scientific environment created by friends and colleagues at the Neuronano Research Center coordinated by Dr. Jens Schouenborg.

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Received: 2013-6-4
Accepted: 2013-7-4
Published Online: 2013-08-02
Published in Print: 2013-08-01

©2013 by Walter de Gruyter Berlin Boston

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