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Nicotinic modulation of serotonergic activity in the dorsal raphe nucleus

  • Salvador Hernandez-Lopez

    Dr. Hernandez received his BS in Psychobiology from Universidad Nacional Autonoma de México (UNAM, 1990) and a PhD in Neurosciences from Centro de Investigación y de Estudios Avanzados (CINVESTAV-IPN), México City (1994). Afterwards, he worked at the Institute of Physiology, UNAM where he studied the effects of dopamine on medium spiny neurons (basal ganglia) from 1994 to 1998. Then, he got a postdoctoral position at the Northwestern University in Chicago where he continued to work on the basal ganglia (1998–2003). Currently, Dr. Hernandez is a professor of physiology at the Faculty of Medicine, UNAM and he pursues research aimed to understand the effect of nicotine on the dorsal raphe nucleus.

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    , Julieta Garduño

    Julieta Garduño received her BS in Biology from Universidad Autonoma Metropolitana, México City (1993), and PhD in Physiology from Centro de Investigación y de Estudios Avanzados del (CINVESTAV-IPN), México City (2000). She was a postdoctoral fellow at the Cajal Institute of Madrid, Spain in the Department of Functional Neurobiology and Systems (2001–2004). After completing her postdoctoral fellowship, she joined the Department of Physiology, Faculty of Medicine at the Universidad Nacional Autonoma de México, where she currently is a Professor of Physiology.

    and Stefan Mihailescu

    Dr. Mihailescu earned his MD title from the Faculty of Medicine of Craiova, Romania and the PhD title (Physiology) from the Faculty of Medicine of Iasi, Romania. He was a postdoctoral fellow in the Department of Physiology, School of Medicine, Columbia, South Carolina. Currently he is Professor at the Department of Physiology of the Universidad Nacional Autonoma de México, México City. His research is focused on nicotine effects on dorsal raphe neurons.

Published/Copyright: September 7, 2013
Become an author with De Gruyter Brill

Abstract

Cholinergic signaling mediated by nicotinic receptors has been associated to a large number of physiological and behavioral processes such as learning, memory, attention, food-intake and mood disorders. Although it is well established that many nicotinic actions are mediated through an increase in serotonin (5-HT) release, the physiological mechanisms by which nicotine produces these effects are still unclear. The dorsal raphe nucleus (DRN) contains the major amount of 5-HT neurons projecting to different parts of the brain. DRN also contains nicotinic acetylcholine receptors (nAChRs) located at somatic and presynaptic elements. Nicotine produces both inhibitory and excitatory effects on different subpopulations of 5-HT DRN neurons. In this review, we describe the presynaptic and postsynaptic mechanisms by which nicotine increases the excitability of DRN neurons as well as the subtypes of nAChRs involved. We also describe the inhibitory effects of nicotine and the role of 5-HT1A receptors in this effect. These nicotinic actions modulate the activity of different neuronal subpopulations in the DRN, changing the 5-HT tone in the brain areas where these groups of neurons project. Some of the physiological implications of nicotine-induced 5-HT release are discussed.


Corresponding author: Salvador Hernandez-Lopez, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F. 04510, México, e-mail:

About the authors

Salvador Hernandez-Lopez

Dr. Hernandez received his BS in Psychobiology from Universidad Nacional Autonoma de México (UNAM, 1990) and a PhD in Neurosciences from Centro de Investigación y de Estudios Avanzados (CINVESTAV-IPN), México City (1994). Afterwards, he worked at the Institute of Physiology, UNAM where he studied the effects of dopamine on medium spiny neurons (basal ganglia) from 1994 to 1998. Then, he got a postdoctoral position at the Northwestern University in Chicago where he continued to work on the basal ganglia (1998–2003). Currently, Dr. Hernandez is a professor of physiology at the Faculty of Medicine, UNAM and he pursues research aimed to understand the effect of nicotine on the dorsal raphe nucleus.

Julieta Garduño

Julieta Garduño received her BS in Biology from Universidad Autonoma Metropolitana, México City (1993), and PhD in Physiology from Centro de Investigación y de Estudios Avanzados del (CINVESTAV-IPN), México City (2000). She was a postdoctoral fellow at the Cajal Institute of Madrid, Spain in the Department of Functional Neurobiology and Systems (2001–2004). After completing her postdoctoral fellowship, she joined the Department of Physiology, Faculty of Medicine at the Universidad Nacional Autonoma de México, where she currently is a Professor of Physiology.

Stefan Mihailescu

Dr. Mihailescu earned his MD title from the Faculty of Medicine of Craiova, Romania and the PhD title (Physiology) from the Faculty of Medicine of Iasi, Romania. He was a postdoctoral fellow in the Department of Physiology, School of Medicine, Columbia, South Carolina. Currently he is Professor at the Department of Physiology of the Universidad Nacional Autonoma de México, México City. His research is focused on nicotine effects on dorsal raphe neurons.

This work was funded by Consejo Nacional de Ciencia y Tecnología (CONACyT) grant 50147-M and Dirección General de Asuntos del Personal Académico-UNAM grants IN212303 and IN220112-3.

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Received: 2013-4-29
Accepted: 2013-8-10
Published Online: 2013-09-07
Published in Print: 2013-10-01

©2013 by Walter de Gruyter Berlin Boston

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