The role of serotonin in the antidyskinetic effects of deep brain stimulation: focus on antipsychotic-induced motor symptoms
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Meaghan C. Creed
Dr. Meaghan C. Creed completed her PhD in Pharmacology at the University of Toronto in September 2012. She currently has a postdoctoral position in Prof. C. Lüscher’s laboratory at the University of Genève. Her research interests are in the area of preclinical models of movement disorders, drug abuse and cognitive dysfunction.
Dr. José N. Nobrega is Senior Scientist and Head of the Behavioural Neurobiology Laboratory at the Centre for Addiction and Mental Health and Professor in the Departments of Psychiatry, Psychology and Pharmacology at the University of Toronto. His research deals primarily with preclinical models of therapeutic interventions in neuropsychiatric disorders, including movement disorders, depression, schizophrenia, addictions and impulse control disorders.
Abstract
Treatment with the classic antipsychotic drugs (APDs), such as haloperidol (HAL), is associated with both acute and chronic motor side effects. Acutely, these drugs may induce extrapyramidal symptoms, whereas a prolonged treatment may result in tardive dyskinesia (TD). Atypical antipsychotics have a lower incidence of motor side effects, which have been partially ascribed to the antagonism of serotonin (5-HT) receptors. Although there is currently no satisfactory pharmacotherapy for TD, deep brain stimulation (DBS) has emerged as a promising therapy. However, the mechanisms underlying its effects remain largely unknown. DBS has been shown to affect several neurotransmitter systems, including 5-HT. In this review, we outline the involvement of 5-HT in the development of HAL-induced catalepsy and TD. We also discuss the evidence for DBS-induced alterations in 5-HT function and the relevance of serotonergic alterations to the antidyskinetic effects of DBS. The evidence suggests that the serotonergic mechanisms may be involved in the acute and chronic motor side effects of APDs as well as in adverse psychiatric effects that have been reported following DBS. However, the current evidence suggests that 5-HT alterations do not play an important role in the effectiveness of DBS in models of dyskinesias induced by chronic APDs.
About the authors
Dr. Meaghan C. Creed completed her PhD in Pharmacology at the University of Toronto in September 2012. She currently has a postdoctoral position in Prof. C. Lüscher’s laboratory at the University of Genève. Her research interests are in the area of preclinical models of movement disorders, drug abuse and cognitive dysfunction.
Dr. José N. Nobrega is Senior Scientist and Head of the Behavioural Neurobiology Laboratory at the Centre for Addiction and Mental Health and Professor in the Departments of Psychiatry, Psychology and Pharmacology at the University of Toronto. His research deals primarily with preclinical models of therapeutic interventions in neuropsychiatric disorders, including movement disorders, depression, schizophrenia, addictions and impulse control disorders.
©2013 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Masthead
- Masthead
- The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson’s disease: a review of in vivo models
- The role of the subthalamic nucleus in cognition
- Physical exercise and Parkinson’s disease: influence on symptoms, disease course and prevention
- The role of serotonin in the antidyskinetic effects of deep brain stimulation: focus on antipsychotic-induced motor symptoms
- Imaging the structure of the human anxious brain: a review of findings from neuroscientific personality psychology
- 5-HT1A receptor as a key player in the brain 5-HT system
- Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders
- Effects of chronic stress on the auditory system and fear learning: an evolutionary approach
