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Transition metal complexes of symmetrical and asymmetrical Schiff bases as antibacterial, antifungal, antioxidant, and anticancer agents: progress and prospects

  • Ikechukwu P. Ejidike

    Ikechukwu P. Ejidike received his Masters degree in 2010 in Analytical Chemistry, from the University of Ibadan, Ibadan, Nigeria. In 2013, he started his PhD in Bioninorganic Chemistry at the Department of Chemistry, University of Fort Hare, South Africa in Prof. Ajibade’s research group. His PhD research activity focuses on synthesis, characterization and biological studies of metal complexes containing heterocyclic N- and O-ligands for potential medicinal applications.

    and Peter A. Ajibade

    Peter A. Ajibade holds a BSc (Honours) in pure and applied chemistry and MSc in inorganic chemistry, both from the University of Ibadan, Nigeria. He started his academic career at the University of Ado-Ekiti, Nigeria before proceeding to South Africa to pursue a doctoral degree. He obtained a PhD in inorganic chemistry from the University of Zululand, South Africa in 2006 and was postdoctoral researcher at the University of Johannesburg before taking up appointment at the University of Fort Hare in April 2007 where he is at present a professor of inorganic materials chemistry. He has published 80 peer-reviewed journal articles and he is leading a thriving research group in inorganic materials in the university with over 20 postgraduate students.

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Published/Copyright: September 3, 2015

Abstract

The huge research on Schiff base coordination complexes in the past few decades has given rise to several new molecules that have been of biological importance. The ease with which the Schiff base ligands are designed and prepared and their pattern is elucidated have made them to be referred to as “fortunate ligands” possessing azomethine derivatives, the C=N linkage that is essential for biological activity, including antibacterial, antifungal, antioxidant, anticancer, and diuretic activities. A variety of Schiff base and its complexes have been studied as model molecules for biological oxygen carrier systems. The uses of Schiff bases as DNA-cleaving agents and its mode of interaction and free-radical scavenging properties are described. The review encapsulates the applications of Schiff bases and their complexes.


Corresponding author: Peter A. Ajibade, Faculty of Science and Agriculture, Department of Chemistry, University of Fort Hare, P.B. X1314, Alice 5700, South Africa, e-mail:

About the authors

Ikechukwu P. Ejidike

Ikechukwu P. Ejidike received his Masters degree in 2010 in Analytical Chemistry, from the University of Ibadan, Ibadan, Nigeria. In 2013, he started his PhD in Bioninorganic Chemistry at the Department of Chemistry, University of Fort Hare, South Africa in Prof. Ajibade’s research group. His PhD research activity focuses on synthesis, characterization and biological studies of metal complexes containing heterocyclic N- and O-ligands for potential medicinal applications.

Peter A. Ajibade

Peter A. Ajibade holds a BSc (Honours) in pure and applied chemistry and MSc in inorganic chemistry, both from the University of Ibadan, Nigeria. He started his academic career at the University of Ado-Ekiti, Nigeria before proceeding to South Africa to pursue a doctoral degree. He obtained a PhD in inorganic chemistry from the University of Zululand, South Africa in 2006 and was postdoctoral researcher at the University of Johannesburg before taking up appointment at the University of Fort Hare in April 2007 where he is at present a professor of inorganic materials chemistry. He has published 80 peer-reviewed journal articles and he is leading a thriving research group in inorganic materials in the university with over 20 postgraduate students.

Acknowledgments

The authors would like to acknowledge the funding received from the Goven Mbeki Research and Development Centre, University of Fort Hare, and NRF-Sasol Inzalo Science fellowships.

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Received: 2015-5-24
Accepted: 2015-7-20
Published Online: 2015-9-3
Published in Print: 2015-12-1

©2015 by De Gruyter

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