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Platinum organometallic compounds: classification and analysis of crystallographic and structural data. Monomeric Pt compounds with PtC2AB, PtA2BC and PtABCD compositions

  • Prof. Dr. Milan Melnik, DrSc graduated from the Comenius University of Bratislava, Slovakia and obtained his PhD (1972) and Doctor of Science (1990) from Slovak Technical University (Slovakia). His main research interest concern the coordination and bio-coordination chemistry of the transition and main group elements. His research is focussed their structure, properties and bioactivity and in the development of new drugs based on the bioactive ligands of the copper complex with regard to antiheumatics and antituberculotics. He has (co)authored 59 scientific monographs and over 350 scientific papers. He is a member of various universities and is the lead scientist of many research projects.

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    Dr. Ondrej Sprusansky, PhD, graduated from the Comenius University of Bratislava, Slovakia (1993) and obtained his PhD (2001) at the same university. He worked at the Slovak Academy of Science, Bratislava several years and at the University of Georgia, Genetics Department, Athens, GA, USA. He currently works as an Assistant Professor at the Pharmaceutical Faculty at Comenius University. He has previously worked on the morphological differentiation and antibiotics, and telomere capping proteins

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    Clive E. Holloway is Professor Emeritus, Department of Chemistry, York University, Toronto, Ontario, Canada. He obtained a MSc and a PhD at the University of Western Ontario, and joined the Department of Chemistry, York University, Toronto, Canada in 1968. His research has included the synthesis, structure and properties of metal complexes. He is the author of over 120 papers mostly on transition or post transition metal compounds. Currently retired, he continues to carry out research as Professor Emeritus at York University.

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    Assoc. Prof. Dr. Peter Mikus, PhD received his MSc in Analytical Chemistry in 1995 from the Faculty of Natural Sciences Comenius University in Bratislava, Slovak Republic. He received his PhD in Analytical Chemistry from the same Faculty in 2002. Currently, he is an Assistant Professor and the Head of the Department of Pharmaceutical Analysis and Nuclear Pharmacy and Director of the Toxicological and Antidoping Center. His research interests include development of new progressive (chiral) capillary electrophoresis separation methods for the advanced pharmaceutical and biomedical analyses of drugs, their (bio) degradation products, and biomarkers. His recent research is also oriented on the crystallography of coordination compounds.

Published/Copyright: December 8, 2012

Abstract

This review covers almost 350 four-coordinated monomeric organoplatinum complexes with PtC2AB, PtA2BC and PtABCD compositions, and there is wide variability of chromophores. The most common ligands in addition to the C donor are PPh3 and chlorine. Platinum(II) is found only in a square-planar environment involving cis- as well as trans-configurations with a different degree of distortion, especially when bi- or terdentate ligands are present. The trans-effect decreases in the order of the atoms in which the effect dominates, H>C>P>Si>S. There are at least two types of isomerism, cis-trans and distortion. The data strongly suggest that distortion isomerism is, for platinum chemistry, more common than cis- and trans-isomerism.


Corresponding author: Milan Melnik, Faculty of Pharmacy, Department of Pharmaceutical Analysis and Nuclear Pharmacy, Comenius University, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic

About the authors

Milan Melnik

Prof. Dr. Milan Melnik, DrSc graduated from the Comenius University of Bratislava, Slovakia and obtained his PhD (1972) and Doctor of Science (1990) from Slovak Technical University (Slovakia). His main research interest concern the coordination and bio-coordination chemistry of the transition and main group elements. His research is focussed their structure, properties and bioactivity and in the development of new drugs based on the bioactive ligands of the copper complex with regard to antiheumatics and antituberculotics. He has (co)authored 59 scientific monographs and over 350 scientific papers. He is a member of various universities and is the lead scientist of many research projects.

Ondrej Sprusansky

Dr. Ondrej Sprusansky, PhD, graduated from the Comenius University of Bratislava, Slovakia (1993) and obtained his PhD (2001) at the same university. He worked at the Slovak Academy of Science, Bratislava several years and at the University of Georgia, Genetics Department, Athens, GA, USA. He currently works as an Assistant Professor at the Pharmaceutical Faculty at Comenius University. He has previously worked on the morphological differentiation and antibiotics, and telomere capping proteins

Clive Eduard Holloway

Clive E. Holloway is Professor Emeritus, Department of Chemistry, York University, Toronto, Ontario, Canada. He obtained a MSc and a PhD at the University of Western Ontario, and joined the Department of Chemistry, York University, Toronto, Canada in 1968. His research has included the synthesis, structure and properties of metal complexes. He is the author of over 120 papers mostly on transition or post transition metal compounds. Currently retired, he continues to carry out research as Professor Emeritus at York University.

Peter Mikus

Assoc. Prof. Dr. Peter Mikus, PhD received his MSc in Analytical Chemistry in 1995 from the Faculty of Natural Sciences Comenius University in Bratislava, Slovak Republic. He received his PhD in Analytical Chemistry from the same Faculty in 2002. Currently, he is an Assistant Professor and the Head of the Department of Pharmaceutical Analysis and Nuclear Pharmacy and Director of the Toxicological and Antidoping Center. His research interests include development of new progressive (chiral) capillary electrophoresis separation methods for the advanced pharmaceutical and biomedical analyses of drugs, their (bio) degradation products, and biomarkers. His recent research is also oriented on the crystallography of coordination compounds.

Received: 2012-9-10
Accepted: 2012-10-31
Published Online: 2012-12-08
Published in Print: 2012-12-01

©2012 by Walter de Gruyter Berlin Boston

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