Startseite Exposure to pesticides and prostate cancer: systematic review of the literature
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Exposure to pesticides and prostate cancer: systematic review of the literature

  • João F.S. Silva EMAIL logo , Inês E. Mattos , Laércio L. Luz , Cleber N. Carmo und Ricardo D. Aydos
Veröffentlicht/Copyright: 31. Mai 2016

Abstract

Introduction:

Investigations about the association between prostate cancer and environmental and/or occupational pesticide exposure have evidenced a possible role of these chemical substances on tumor etiology, related to their action as endocrine disruptors.

Objective:

To assess the association between pesticide exposure and prostate cancer by conducting a systematic review of the scientific literature.

Materials and methods:

Articles published until August 18, 2015 were searched in the databases MEDLINE/Pubmed, Scielo, and Lilacs using the keywords “pesticides” and “prostate cancer”. Only the analytical observational studies whose methodological quality met the criteria established by the New Castle-Ottawa scale were included in this review.

Results:

The review included 49 studies published between 1993 and 2015. All studies were in English and analyzed exposure to pesticides and/or agricultural activities. Most studies (32 articles) found a positive association between prostate cancer and pesticides or agricultural occupations, with estimates ranging from 1.01 to 14.10.

Conclusion:

The evidence provided by the reviewed studies indicates a possible association between the development of prostate cancer and pesticide exposure and/or agricultural occupations.

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Received: 2016-1-18
Accepted: 2016-4-22
Published Online: 2016-5-31
Published in Print: 2016-9-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

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