Overcoming the obstacle of excess acetonitrile content in the final fluorine-18 radiotracers
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Mohammed Al-Qahtani
Abstract
Acetonitrile is widely used as a solvent in synthesizing various fluorine-18 positron emission tomography (PET) radiotracers. Acetonitrile is classified as a Class II residual solvent, and due to its inherent toxic properties, the quantity of residual acetonitrile in drug products has to be limited. When working under Good Manufacturing Practices (GMP) during the radiosynthesis of a radiotracer, the aim is to control all solvent concentrations contained in the ready-to-use product. All products must meet predetermined specifications. Rarely, these limits may be exceeded. To avoid eliminating the entire batch, applying a straightforward time-based technique would be desirable to allow the majority of the product to be safely used. This technique should be based on determining a specific time and volume for which the radiotracer can be utilized in the patients after completing quality control analysis. Here, we report a very simple Excel sheet program based on existing mathematical equations that calculates the exact time and volume at which the radiotracer product can be safely administered to a patient.
Acknowledgments
The author thanks King Faisal Specialist Hospital and Research Centre (KFSH&RC) (RAC # 2130 022) and to Mohammad Shoaib Shawoo for his technical assistance.
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Research ethics: Not applicable.
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Author contributions: The author has accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The author state no conflict of interest.
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Research funding: None declared.
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Data availability: Not applicable.
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Original Papers
- Morphology of uranium oxides reduced from magnesium and sodium diuranate
- HR GRS-HPGe as NDT method for quantification of uranium and 235U content in process stream samples from UO2 fuel production facilities
- Recycling waste polymer packaging materials as effective active carbon porous materials for uranium removal from commercial phosphoric acid
- Overcoming the obstacle of excess acetonitrile content in the final fluorine-18 radiotracers
- Radioactivity of 226Ra, 232Th and 40K in soil in Northwest part of Turkey: assessment of radiological impacts
- Determination of natural radionuclides and heavy metal concentrations in the groundwater and adjacent areas of the Kattakurgan reservoir, Uzbekistan
- Obituary
- Obituary: Jae-Il Kim (1936–2023)
Articles in the same Issue
- Frontmatter
- Original Papers
- Morphology of uranium oxides reduced from magnesium and sodium diuranate
- HR GRS-HPGe as NDT method for quantification of uranium and 235U content in process stream samples from UO2 fuel production facilities
- Recycling waste polymer packaging materials as effective active carbon porous materials for uranium removal from commercial phosphoric acid
- Overcoming the obstacle of excess acetonitrile content in the final fluorine-18 radiotracers
- Radioactivity of 226Ra, 232Th and 40K in soil in Northwest part of Turkey: assessment of radiological impacts
- Determination of natural radionuclides and heavy metal concentrations in the groundwater and adjacent areas of the Kattakurgan reservoir, Uzbekistan
- Obituary
- Obituary: Jae-Il Kim (1936–2023)
