Efficient trace-scale extraction method of reactor produced 199Au adequate for nuclear medicine applications

Mohamed F. Attallah; Ahmed M. Shahr El-Din; Mohamed A. Gizawy; Amal M. I. Ali

doi:10.1515/ract-2020-0108

Article

Efficient trace-scale extraction method of reactor produced ¹⁹⁹Au adequate for nuclear medicine applications

Mohamed F. Attallah , Ahmed M. Shahr El-Din , Mohamed A. Gizawy and Amal M. I. Ali

Published/Copyright: February 19, 2021

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From the journal Radiochimica Acta Volume 109 Issue 5

Abstract

Production of no carrier-added (NCA) ¹⁹⁹Au through ^natPt(n, γ) reaction and subsequent purification using liquid-liquid extraction from other radioisotopes is studied in the context of theranostic application. Comparative separation of NCA ¹⁹⁹Au after dissolution of activated Pt target using three Cyanex compounds (Cyanex-272, Cyanex-302 and Cyanex-923) is evaluated. The extraction process is optimized in terms of the type of extractant, the concentration of extractant, extraction time and aqueous media (HNO₃, NH₄OH). Among these extractants, the Cynaex-923 is efficient and promising for rapid separation and production of NCA ¹⁹⁹Au from HNO₃ by high extraction %. Selective extraction of ¹⁹⁹Au from other Pt and Ir radioisotopes is observed. High recovery of ¹⁹⁹Au was obtained in the case of Cyanex-923 using 0.05 M thiourea dissolved in HCl or 2 M NaOH. Our results find the Cyanex-923 as a promising extractant for efficient separation of ¹⁹⁹Au from irradiated Pt target with high yield (99%).

Keywords: chemical separation; nuclear medicine; nuclear reaction; radioisotope production; theranostic radionuclide 199Au

Corresponding author: Mohamed F. Attallah, Analytical Chemistry and Control Department, Hot Laboratories Center, Atomic Energy Authority of Egypt, P.O. Box 13759, Cairo, Egypt, E-mail: dr.m.f.attallah@gmail.com

Acknowledgements

M.F. Attallah would like to acknowledge and extend appreciation to the crew of 2nd Egyptian Nuclear Research Reactor (ETRR-2) at the EAEA for their valuable assistance in the course of production of requested radioisotopes in due time. The authors express special thanks to Prof. Dr. S. M. Qaim, the Editor-in-Chief of Radiochimica Acta, for his valuable efforts and comments to improve our paper.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2020-10-31

Accepted: 2021-02-06

Published Online: 2021-02-19

Published in Print: 2021-05-26

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Articles in the same Issue

https://doi.org/10.1515/ract-2020-0108

Keywords for this article

chemical separation; nuclear medicine; nuclear reaction; radioisotope production; theranostic radionuclide 199Au