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Radioiodination and biological evaluation of landiolol as a tracer for myocardial perfusion imaging: preclinical evaluation and diagnostic nuclear imaging

  • M. H. Sanad EMAIL logo , A. B. Farag and M. A. Motaleb
Published/Copyright: September 1, 2018
Radiochimica Acta
From the journal Radiochimica Acta Volume 106 Issue 12

Abstract

The present work has assessed the ability and competency of radioiodinated landiolol that is considered a potential cardio selective imaging agent. Landiolol was radiosynthesized with [131I] using chloramine-T (Ch-T) as an oxidizing agent. To give high radiochemical yield of the [131I]landiolol reaching values of 98% with high stability up to 48 h. The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoresis and high performance liquid chromatography (HPLC). Biodistribution studies indicated that [131I]landiolol gave high heart uptake ratio of [45.0±0.19% ID/g at 2 min post injection (p.i.)]. Therefore, [131I]landiolol could be considered as a novel tracer to image heart with high heart/blood ratio within 60 min.

Keywords: Landiolol; iodine-131; heart imaging; gamma scintigraphy

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/ract-2018-2980).

Received: 2018-05-04
Accepted: 2018-07-10
Published Online: 2018-09-01
Published in Print: 2018-11-27

©2018 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Online chemical adsorption studies of Hg, Tl, and Pb on SiO2 and Au surfaces in preparation for chemical investigations on Cn, Nh, and Fl at TASCA
  3. Thermodynamic parameters for the complexation of technetium(IV) with EDTA
  4. Sorption of Eu(III) on Fe–montmorillonite relevant to geological disposal of HLW
  5. Study of the redistribution of U, Zr, Nb, Tc, Mo, Ru, Fe, Cr, and Ni between oxide and metallic phases in the matrix of a multiphase Chernobyl hot-particle extracted from a soil sample of the Western Plume
  6. 99Mo/99mTc radioisotope generator based on adsorption of 99Mo (VI) on cerium (IV) molybdate column matrix
  7. Radioiodination and biological evaluation of landiolol as a tracer for myocardial perfusion imaging: preclinical evaluation and diagnostic nuclear imaging
  8. Study on gamma ray shielding performance of concretes doped with natural sepiolite mineral
  9. Neural network prediction of K and L-shell X-ray production cross sections
https://doi.org/10.1515/ract-2018-2980
Keywords for this article
Landiolol; iodine-131; heart imaging; gamma scintigraphy

Articles in the same Issue

  1. Frontmatter
  2. Online chemical adsorption studies of Hg, Tl, and Pb on SiO2 and Au surfaces in preparation for chemical investigations on Cn, Nh, and Fl at TASCA
  3. Thermodynamic parameters for the complexation of technetium(IV) with EDTA
  4. Sorption of Eu(III) on Fe–montmorillonite relevant to geological disposal of HLW
  5. Study of the redistribution of U, Zr, Nb, Tc, Mo, Ru, Fe, Cr, and Ni between oxide and metallic phases in the matrix of a multiphase Chernobyl hot-particle extracted from a soil sample of the Western Plume
  6. 99Mo/99mTc radioisotope generator based on adsorption of 99Mo (VI) on cerium (IV) molybdate column matrix
  7. Radioiodination and biological evaluation of landiolol as a tracer for myocardial perfusion imaging: preclinical evaluation and diagnostic nuclear imaging
  8. Study on gamma ray shielding performance of concretes doped with natural sepiolite mineral
  9. Neural network prediction of K and L-shell X-ray production cross sections
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