Recovery of Ra-223 from natural thorium irradiated by protons

Aleksandr N. Vasiliev; Valentina S. Ostapenko; Elena V. Lapshina; Stanislav V. Ermolaev; Sergey S. Danilov; Boris L. Zhuikov; Stepan N. Kalmykov

doi:10.1515/ract-2015-2549

Article

Recovery of Ra-223 from natural thorium irradiated by protons

Aleksandr N. Vasiliev , Valentina S. Ostapenko , Elena V. Lapshina , Stanislav V. Ermolaev , Sergey S. Danilov , Boris L. Zhuikov and Stepan N. Kalmykov

Published/Copyright: April 7, 2016

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From the journal Radiochimica Acta Volume 104 Issue 8

Abstract

Irradiation of natural thorium with medium-energy protons is considered to be a prospective approach to large-scale production of ²²⁵Ac and ²²³Ra. In addition to the earlier-developed method of ²²⁵Ac isolation, the present work focuses on the simultaneous recovery of.²²³Ra from the same thorium target. Radiochemical procedure is based on liquid-liquid extraction, cation exchange and extraction chromatography. The procedure provides separation of radium from spallation and fission products generated in the thorium target. High chemical yield (85– 90%) and radionuclide purity of ²²³Ra (> 99.8% except ²²⁴Raand ²²⁵Ra isotopes) have been achieved.

Keywords:: Thorium metal; proton iradiation; radium isotopes; ion exchange; extraction chromatography

Acknowledgement

The authors are grateful to V. M. Kokhanyuk and O. V. Nastoyaschaya (INR) for their assistance in the experiments. The authors are also grateful to Steffen Happel (Triskem Int.) for providing the samples of extraction chromatographic resins and L. I. Guseva from the Institute of Geochemistry and Analytical Chemistry of RAS for helpful consulting in chromatography of radium.

References

1. Zimmermann, R.: Nuclear Medicine. Radioactivity for Diagnosis and Therapy, Lez Ulis: EDP Sciences (2007) 173 p.10.1051/978-2-7598-0255-5Search in Google Scholar

2. Guseva, L. I., Tikhomirova, G. S.: A ²¹¹Pb generator as a methodical approach to studying the chemistry of element 114 in solutions, Radiokhimiya 44(2), 154 – 157 (2002).Search in Google Scholar

3. Trewartha, D., Carter, K.: Advances in prostate cancer treatment, Nat. Rev. Drug Discov. 12(11), 823–824 (2013).10.1038/nrd4068Search in Google Scholar PubMed

4. Parker, C., Nilsson, S., Heinrich, D., Helle, S. I., O’Sullivan, J. M., Fosså, S. D., Sartor, O.: Alpha emitter radium-223 and survival in metastatic prostate cancer, N. Engl. J. Med. 369(3), 213–223 (2013).10.1056/NEJMoa1213755Search in Google Scholar PubMed

5. Nilsson, S., Larsen, R. H., Fosså, S. D., Balteskard, L., Borch, K. W., Westlin, J. E., Bruland, Ø. S.: First clinical experience with α-emitting radium-223 in the treatment of skeletal metastases, Clin. Cancer Res. 11(12), 4451–4459 (2005).10.1158/1078-0432.CCR-04-2244Search in Google Scholar PubMed

6. Miao, Y., Hylarides, M., Fisher, D. R., Shelton, T., Moore, H., Wester, D. W., Fritzberg, A. R., Winkelmann, Ch. T., Hoffman, T., Quinn, T. P.: Melanoma therapy via peptide-targeted alpharadiation, Clin. Cancer Res. 11, 5616–5626 (2005).10.1158/1078-0432.CCR-05-0619Search in Google Scholar PubMed

7. Harrington, K. J., Mohammadtah, S., Uster, P. S., Glass, D., Peters, A. M., Stewart, J. S.: Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes, Clin. Cancer Res. 7(2), 243 (2001).Search in Google Scholar

8. Henriksen, G., Schoultz, B. W., Michaelsen, T. E., Bruland, Ø. S., Larsen, R. H.: Sterically stabilized liposomes as a carrier for α-emitting radium and actinium radionuclides, Nucl. Med. Biol. 31, 441–449 (2004).10.1016/j.nucmedbio.2003.11.004Search in Google Scholar PubMed

9. Vengalil, S., O’Sullivan, J. M., Parker, C. C.: Use of radionuclides in metastatic prostate cancer: pain relief and beyond, Curr. Opin. Support. Palliat. Care 6(3), 310–315 (2012).10.1097/SPC.0b013e328355e082Search in Google Scholar PubMed

10. Kozempel, J., Vlk, M., Malkova, E., Bajzıkova, A., Barta, J., Santos-Oliveira, R., Malta Rossi, A.: Prospective carriers of ²²³Ra for targeted alpha therapy, J. Radioanal. Nucl. Chem. 304, 443–447 (2015).10.1007/s10967-014-3615-ySearch in Google Scholar

11. Henriksen, G., Hoff, P., Alstad, J., Larsen, R. H.: ²²³Ra for Endoradiotherapeutic applications prepared from animmobilized ²²⁷Ac/²²⁷Th source, Radiochim. Acta 89, 661–666 (2001).10.1524/ract.2001.89.10.661Search in Google Scholar

12. Peterson, S.: In: Seaborg, G. T., Katz, J. J., Manning, W. U. (eds), Transuranium elements, Part II, 1st edn. McGraw-Hill, New York (1949).Search in Google Scholar

13. Kuznetsov, R. A., Butkalyuk, P. S., Tarasov, V. A., Baranov, A. Yu., Butkalyuk, I. L., Romanov, E. G., Kupriyanov, V. N., Kazakova, E. V.: Yields of activation products in ²²⁶Ra irradiation in the high-flux SM reactor, Radiochemistry 54(4), 383– 387 (2012).10.1134/S1066362212040121Search in Google Scholar

14. Bagheri, R., Afarideh, H., Ghannadi-Maragheh, M., Bahrami-Samani, A., Shirvani-Arani, S.: Production of ²²⁴Ra from ²²⁶Ra in Tehran Research Reactor for treatment of bone metastases, J. Radioanal. Nucl. Chem. 304(3), 1185–1191 (2015).10.1007/s10967-015-3931-xSearch in Google Scholar

15. Guseva, L. I., Tikhomirova, G. S., Dogadkin, N. N.: Anionexchange separation of radium from alkaline-earth metals and actinides in aqueous-methanol solutions of HNO_3.²²⁷Ac ²²³Ra Generator, Radiochemistry 46(1), 58–62 (2004).10.1023/B:RACH.0000024637.39523.e4Search in Google Scholar

16. Zhuikov, B. L., Kalmykov, S. N., Ermolaev, S. V., Aliev, R. A., Kokhanyuk, V. M., Matushko, V. L., Tananaev, I. G., Myasoedov, B. F.: Production of ²²⁵Ac and ²²³Ra by irradiation of Th with accelerated protons Radiochemistry 53, 1, 73–80 (2011).10.1134/S1066362211010103Search in Google Scholar

17. Ermolaev, S. V., Zhuikov, B. L., Kokhanyuk, V. M., Matushko, V. M., Kalmykov, V. L., Aliev, S. N., Tananaev, I. G., Myasoedov, B. F.: Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV, Radiochim. Acta 100, 1–7 (2012).10.1524/ract.2012.1909Search in Google Scholar

18. Aliev, R. A., Ermolaev, S. V., Vasiliev, A. N., Ostapenko, V. S., Lapshina, E. V., Zhuikov, B. L., Zakharov, N. V., Pozdeev, V. V., Kokhanyuk, V. M., Myasoedov, B. F., Kalmykov, S. N.: Isolation of medicine-applicable actinium-225 from thorium targets irradiated by medium-energy protons, Solv. Extr. Ion Exch. 32(5), 468–477 (2014).10.1080/07366299.2014.896582Search in Google Scholar

19. Radchenko, V., Engle, J. W., Wilson, J. J., Maassen, J. R., Nortier, F. M., Taylor, W. A., Birnbaum, E. R., Hudston, L. A., John, K. D., Fassbender, M. E.: Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes, J. Chromatogr. A 1380 55–63 (2015).10.1016/j.chroma.2014.12.045Search in Google Scholar

20. National Nuclear Data Center, Brookhaven National Laboratory, USA, http://www.nndc.bnl.gov/nudat2.Search in Google Scholar

21. Weigl, M., Geist, A., Müllich, U.,Gompper, K.: Kinetics of americium III) extraction and back extraction with BTP, Solv. Extr. Ion Exch. 24(6), 845–860 (2006).10.1080/07366290600948582Search in Google Scholar

22. Horwitz, P. E., Chiarizia, R., Dietz, M. L.: A novel strontiumselective extraction chromatographic resin, Solv. Extr. Ion Exch. 10(2), 313–336 (1992).10.1080/07366299208918107Search in Google Scholar

23. Berthod, A., Carda-Broch, S.: Determination of liquid–liquid partition coefficients by separation methods, J. Chromatogr. A 1037(1), 3–14 (2004).10.1016/j.chroma.2004.01.001Search in Google Scholar

24. Hiraoka, M.: Crown Compounds: Their Characteristics and Applications, Elsevier: New York, 1982.Search in Google Scholar

25. Horwitz, P.: Radium Separation Method, 57-th Radiobioassay & Radiochemical Measurements Conference Sandestin, Florida, 431–435 (2011).Search in Google Scholar

26. Schulz, W. W., Navratil, J. D.: Science and technology of tributyl phosphate. Vol. I: Synthesis, properties, reactions and analysis, Rockwell Hanford Operations, Richland, WA (1984).Search in Google Scholar

27. Šulcek, Z., Doležal J., Michal, J., Sychra, V.: Rapid analytical methods for the determination of metals and inorganic materials – XIII: Determination of tin in metallic antimony, Talanta 10(1), 3–11 (1963).10.1016/0039-9140(63)80199-XSearch in Google Scholar

28. Hogan, J. J., Gadioli, E., Gadioli-Erba, E., Chung, C.: Fissionability of nuclides in the thorium region at excitation energies to 100 MeV, Phys. Rev. C 20(5), 1831, (1979).10.1103/PhysRevC.20.1831Search in Google Scholar

29. Weidner, J. W., Mashnik, S. G., John, K. D., Hemez, F., Ballard, B., Bach, H., Birnbaum, E. R., Bitteker, L. J., Couture, A., Dry, D., Fassbender, M. E., Gulley, M. S., Jackman, K. R., Ullmann, J. L., Wolfsberg, L. E., Nortier, F. M.: Proton-induced cross sections relevant to production of ²²⁵Ac and ²²³Ra in natural thorium targets below 200 MeV, Appl. Rad. Isot. 70, 2602–2607 (2012).10.1016/j.apradiso.2012.07.006Search in Google Scholar PubMed

Received: 2015-11-23

Accepted: 2016-2-22

Published Online: 2016-4-7

Published in Print: 2016-8-1

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Articles in the same Issue

https://doi.org/10.1515/ract-2015-2549

Keywords for this article

Thorium metal; proton iradiation; radium isotopes; ion exchange; extraction chromatography