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Post-target produced [18F]F2 in the production of PET radiopharmaceuticals
-
Sarita Forsback
and
Olof Solin
Published/Copyright:
December 18, 2014
Abstract
Electrophilic radiofluorination was successfully carried out in the early years of PET radiochemistry due to its ease and fast reaction speed. However, at the present, the use of electrophilic methods is limited due to low specific activity (SA). Post-target produced [18F]F2 has significantly higher SA compared to other electrophilic approaches, and it has been used in the production of clinical PET radiopharmaceuticals at the Turku PET Centre for years. Here, we summarize the synthesis and use of these radiopharmaceuticals, namely [18F]FDOPA, [18F] CFT, [18F]EF5 and [18F]FBPA.
Keywords: Post-target produced [18F]F2; electrophilic fluorination; specific activity; radiopharmaceutical; PET
Received: 2014-3-4
Accepted: 2014-10-30
Published Online: 2014-12-18
Published in Print: 2015-3-28
©2014 Walter de Gruyter Berlin/Boston
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Keywords for this article
Post-target produced [18F]F2;
electrophilic fluorination;
specific activity;
radiopharmaceutical;
PET
Articles in the same Issue
- Frontmatter
- Preface
- Radiochemistry in Northern Europe
- Fuel fabrication and reprocessing for nuclear fuel cycle with inherent safety demands
- Partitioning and speciation of Pu in the sedimentary rocks aquifer from the deep liquid nuclear waste disposal
- Sequential extraction as a tool for mobility studies of radionuclides and metals in soils and sediments
- Technetium sulfide – formation kinetics, structure and particle speciation
- Sorption of actinides onto nanodiamonds
- Sorption processes of radiocesium in soil and bedrock
- Post-target produced [18F]F2 in the production of PET radiopharmaceuticals
- Towards automated solid phase radiofluorination for dose-on-demand PET: retention of activity by solid support
