Iodine-125 Chitosan-Vitamin C Complex: preparation, characterization and application
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Ahmed M. Elbarbary
Abstract
In heterogeneous conditions, water soluble Chitosan-Vitamin C Complex (CSVC) is successfully synthesized via the ionic interaction between γ-degraded CS and VC. Chitosan (CS) of low molecular weight (MW) is prepared using γ-irradiation method. The coupling of CS and vitamin C (VC) is carried out by the chemical treatment of VC with the γ-degraded CS. The formation of CSVC complex instead of physical mixture is confirmed by FT-IR and UV spectrometry. Characterization by transmission electron microscope (TEM) and dynamic light scattering (DLS) shows the formation of a nanostructure in 40 nm range. The preparation of labeled CSVC was performed using chloramines-T oxidation method. The labeling feasibility of CSVC nanostructure by Iodine-125 (125I) is investigated. The optimized conditions of labeling are thought to be 50 μg of oxidizing agent, pH 3, and one minute reaction time. The Biodistribution activity of 125I radiolabeled CSVC nanostructure (125I-CSVC) is examined on a group of different ascites tumor bearing mice. Calculation of the biodistribution percentages shows that the tumor, liver, and kidney are the targeting organs of 125I-CSVC nanostructure.
©2015 Walter de Gruyter Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Ground-state and isomeric-state cross sections for the 138Ce(n,2n)137Ce reaction from its threshold to 20 MeV
- Determination of the 151Sm half-life
- Kinetics of reductive stripping of Np(VI) by acetohydroxamic acid from 30%TBP/kerosene to nitrate medium using a high-speed stirred cell
- Characteristic and mechanism of Th4+ sorption from nitric acid solutions by rice and wheat bran
- Kinetics of ion flotation of Co(II)–EDTA complexes from aqueous solutions
- Preparation and biodistribution assessment of 111In-BPAMD as a novel agent for bone SPECT imaging
- Iodine-125 Chitosan-Vitamin C Complex: preparation, characterization and application
- Neutron activation analysis of polyethylene from neutron shield of EDELWEISS experiment
