Radioiodine labeled CdSe/CdS quantum dots: Lectin targeted dual probes
-
Ozlet Akca
,
E. Ilker Medine
Abstract
CdSe/CdS quantum dots (QD) were synthesized and bioconjugated with Sambucus nigra agglutinin (SNA) lectin (Lec). Mannose triflate and cysteamine molecules (MTC) were also utilized to prepare MTC-QDs and MTC-QDs-Lec probes as well as Lec bound QDs. Afterwards; potential use of these nanoparticles as radiolabeled fluorescence nano-probes for the cell imaging studies has been investigated. Biological activities of 125I–, 125I-MTC-QDs, MTC-QDs- Lec-125I, QDs-Lec-125I and Lec-125I were examined on various cancer cell lines such as Caco-2, MCF-7 and A-549 in terms of cell incorporation. QDs-Lec-125I exhibited the highest cell incorporation on whole cell lines. In addition, the QDs-Lec-131I, was used for in vivo imaging. The whole body distribution of the radiolabeled QDs on New Zealand rabbits and Balb C mice were examined by taking dynamic and static images. Radioactivity cleared from the kidneys and the bladder, while significant amount radioactivity was retained in the heart and liver within 24 h.
©2014 Walter de Gruyter Berlin/Boston
Articles in the same Issue
- Frontmatter
- Cm(III) sorption by silica: effect of alpha hydroxy isobutyric acid
- Spectroscopic study of Np(V) oxidation to Np(VI) in 3 mol/dm3 nitric acid at elevated temperatures
- Binary and ternary complexation of NpO2+ with carboxylate and aminocarboxylate ligands
- Sequestration of uranium on fabricated aluminum co-precipitated with goethite (Al-FeOOH)
- Analysis of barium borosilicate glass matrix for uranium determination by using ns-IR-LIBS in air and Ar atmosphere
- Synthesis of ordered mesoporous U3O8 by a nanocasting route
- Thermodynamic model for the solubility of BaSeO4(cr) in the aqueous Ba2+-SeO42−-Na+-H+-OH−-H2O system: Extending to high selenate concentrations
- Evaluation of a novel and efficient solvent system containing chlorinated cobalt dicarbollide for radio-cesium recovery from acidic wastes
- Modelling of niobium sorption on clay minerals in sodium and calcium perchlorate solutions
- Radioiodine labeled CdSe/CdS quantum dots: Lectin targeted dual probes
Articles in the same Issue
- Frontmatter
- Cm(III) sorption by silica: effect of alpha hydroxy isobutyric acid
- Spectroscopic study of Np(V) oxidation to Np(VI) in 3 mol/dm3 nitric acid at elevated temperatures
- Binary and ternary complexation of NpO2+ with carboxylate and aminocarboxylate ligands
- Sequestration of uranium on fabricated aluminum co-precipitated with goethite (Al-FeOOH)
- Analysis of barium borosilicate glass matrix for uranium determination by using ns-IR-LIBS in air and Ar atmosphere
- Synthesis of ordered mesoporous U3O8 by a nanocasting route
- Thermodynamic model for the solubility of BaSeO4(cr) in the aqueous Ba2+-SeO42−-Na+-H+-OH−-H2O system: Extending to high selenate concentrations
- Evaluation of a novel and efficient solvent system containing chlorinated cobalt dicarbollide for radio-cesium recovery from acidic wastes
- Modelling of niobium sorption on clay minerals in sodium and calcium perchlorate solutions
- Radioiodine labeled CdSe/CdS quantum dots: Lectin targeted dual probes
