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Photoprotection strategies with antioxidant extracts: a new vision

  • Radia Ayad ORCID logo EMAIL logo , Mostefa Lefahal , El Hani Makhloufi and Salah Akkal
Published/Copyright: April 19, 2023
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Abstract

The most harmful to biological compounds is ultraviolet radiation (UVR) from the sun. UVC rays (100–280 nm) are extremely harmful to the skin. Fortunately, it is primarily absorbed in the earth’s troposphere by molecular oxygen and ozone. Although UVB (290–320 nm) accounts for only about 5 % of terrestrial UVR, its effects are typically much stronger than those of UVA (320–400 nm). UVR’s clinical effects on normal-appearing human skin can include erythema, pigmentation, suppression of acquired immunity and enhancement of innate immunity, all caused by UVB, and blood pressure reduction caused by UVA. Long-term effects include photocarcinogenesis and photoaging. All of these effects are supported by molecular or cellular effects such as DNA damage, ROS generation, melanogenesis, and the expression of numerous genes and related proteins. The use of sunscreen and avoiding prolonged sun exposure are the first lines of defense in photoprotection. Sunscreens with the appropriate SPF and protection spectrum are now the mainstay of many studies on UV damage. A variety of novel strategies for developing better sunscreens have been proposed. It has been proposed that incorporating antioxidant phenolic extracts into sunscreens can provide additional photoprotective qualities and provide greater protection by replenishing the skin’s natural reservoirs. Thus, the goal of this study was to look into the use of antioxidant extracts from medicinal plants in sunscreens and cosmetic formulations to boost photoprotection, with a particular emphasis on green extraction of these antioxidants from their complex matrices.


Corresponding author: Radia Ayad, Department of Chemistry, Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, University Frères Mentouri Constantine 1 P.O. Box, 325 Ain El Bey Way, Constantine 25017, Algeria; and Department of Chemistry, Laboratory of Phytochemistry and Pharmacology, Faculty of Exact Sciences and Informatics, University Mohammed Seddik Benyahia of Jijel, Jijel 18000, Algeria, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2022-11-08
Accepted: 2023-03-23
Published Online: 2023-04-19

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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