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Fumaric acid: fermentative production, applications and future perspectives

  • Masrat Mohmad , Nivedita Agnihotri ORCID logo EMAIL logo and Vikas Kumar ORCID logo
Published/Copyright: September 14, 2022
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 9 Issue 1

Abstract

The rising prices of petroleum-based chemicals and the growing apprehension about food safety and dairy supplements have reignited interest in fermentation process to produce fumaric acid. This article reviews the main issues associated with industrial production of fumaric acid. Different approaches such as strain modulation, morphological control, selection of substrate and fermentative separation have been addressed and discussed followed by their potential towards production of fumaric acid at industrial scale is highlighted. The employment of biodegradable wastes as substrates for the microorganisms involved in fumaric acid synthesis has opened an economic and green route for production of the later on a commercial scale. Additionally, the commercial potential and technological approaches to the augmented fumaric acid derivatives have been discussed. Conclusion of the current review reveals future possibilities for microbial fumaric acid synthesis.

Keywords: downstream process; fermentation; fumarates; fumaric acid; genetic engineering; Rhizopus oryzae
Corresponding author: Nivedita Agnihotri, Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, India, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2022-07-08
Accepted: 2022-07-29
Published Online: 2022-09-14

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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  11. Flexural analysis of hemp, kenaf and glass fibre-reinforced polyester resin
  12. Manufacturing defects of woven natural fibre thermoset composites
  13. Fumaric acid: fermentative production, applications and future perspectives
  14. Modeling, simulation and mixing time calculation of stirred tank for nanofluids using partially-averaged Navier–Stokes (PANS) k u  − ϵ u turbulence model
  15. Malic acid: fermentative production and applications
  16. Biotic farming using organic fertilizer for sustainable agriculture
  17. An overview about the approaches used in the production of alpha-ketoglutaric acid with their applications
  18. Conscientiousness of environmental concepts in sustainable development and ecological conservation
  19. Biochar: its characteristics application and utilization of on environment
  20. Biofuel as an alternative energy source for environmental sustainability
  21. Evaluation of the crystal structures of metal(II) 2-fluorobenzoate complexes
  22. Role of science in environmental conservation leading to sustainable development
  23. The phytotherapeutic potential of commercial South African medicinal plants: current knowledge and future prospects
  24. Pharmaceutical and personal care products (PPCPs) and per- and polyfluoroalkyl substances (PFAS) in East African water resources: progress, challenges, and future
  25. Embedding systems thinking in tertiary chemistry for sustainability
  26. Clean technology for sustainable development by geopolymer materials
  27. Role of semiconductor photo catalysts on mask pollution management
  28. An overview of mechanical and corrosion properties of aluminium matrix composites reinforced with plant based natural fibres
  29. Physical and mechanical properties of Acacia mangium plywood after sanding treatment
  30. Simple naturally occurring β-carboline alkaloids – role in sustainable theranostics
  31. A SWOT analysis of artificial intelligence in diagnostic imaging in the developing world: making a case for a paradigm shift
  32. Health in poultry- immunity and microbiome with regard to a concept of one health
https://doi.org/10.1515/psr-2022-0161
Keywords for this article
downstream process; fermentation; fumarates; fumaric acid; genetic engineering; Rhizopus oryzae

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Effect of sugarcane bagasse on thermal and mechanical properties of thermoplastic cassava starch/beeswax composites
  4. Investigation on impact properties of different type of fibre form: hybrid hemp/glass and kenaf/glass composites
  5. Material selection and conceptual design in natural fibre composites
  6. Fundamental study of commercial polylactic acid and coconut fiber/polylactic acid filaments for 3D printing
  7. Amine compounds post-treatment on formaldehyde emission and properties of urea formaldehyde bonded particleboard
  8. Properties of plybamboo manufactured from two Malaysian bamboo species—
  9. Mechanical performance and failure characteristics of cross laminated timber (CLT) manufactured from tropical hardwoods species
  10. Effect of stacking sequence on tensile properties of glass, hemp and kenaf hybrid composites
  11. Flexural analysis of hemp, kenaf and glass fibre-reinforced polyester resin
  12. Manufacturing defects of woven natural fibre thermoset composites
  13. Fumaric acid: fermentative production, applications and future perspectives
  14. Modeling, simulation and mixing time calculation of stirred tank for nanofluids using partially-averaged Navier–Stokes (PANS) k u  − ϵ u turbulence model
  15. Malic acid: fermentative production and applications
  16. Biotic farming using organic fertilizer for sustainable agriculture
  17. An overview about the approaches used in the production of alpha-ketoglutaric acid with their applications
  18. Conscientiousness of environmental concepts in sustainable development and ecological conservation
  19. Biochar: its characteristics application and utilization of on environment
  20. Biofuel as an alternative energy source for environmental sustainability
  21. Evaluation of the crystal structures of metal(II) 2-fluorobenzoate complexes
  22. Role of science in environmental conservation leading to sustainable development
  23. The phytotherapeutic potential of commercial South African medicinal plants: current knowledge and future prospects
  24. Pharmaceutical and personal care products (PPCPs) and per- and polyfluoroalkyl substances (PFAS) in East African water resources: progress, challenges, and future
  25. Embedding systems thinking in tertiary chemistry for sustainability
  26. Clean technology for sustainable development by geopolymer materials
  27. Role of semiconductor photo catalysts on mask pollution management
  28. An overview of mechanical and corrosion properties of aluminium matrix composites reinforced with plant based natural fibres
  29. Physical and mechanical properties of Acacia mangium plywood after sanding treatment
  30. Simple naturally occurring β-carboline alkaloids – role in sustainable theranostics
  31. A SWOT analysis of artificial intelligence in diagnostic imaging in the developing world: making a case for a paradigm shift
  32. Health in poultry- immunity and microbiome with regard to a concept of one health
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