Hybrid mesoporous silica composite nano drug carrier modified by CTS-poly(NIPAM-co-AA)
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Keju Zhang
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Lei Xie
Abstract
At present, the forefront of drug carrier research revolves around crafting nano-sized carriers, particularly using hybrid mesoporous silica nanoparticles (MSNs). This study reported the fabrication of 180 nm MSNs featuring an ethane bridge skeleton structure, starting with the synthesis of MSNs, modifications were made by first applying γ-methacryloxypropyl trimethoxysilane (MPS) onto the MSNs. Following this, N-isopropyl acrylamide (NIPAM), acrylic acid (AA), and carboxymethyl chitosan (CTS) were grafted onto the MSNs, resulting in the successful creation of the composite MSNs-CTS-poly(NIPAM-co-AA) (abbreviated as MSNs-CTS-PNA) nano drug carrier. The experimental findings highlighted a notable drug encapsulation efficiency (75.5 ± 2.7 %) due to the core–shell architecture of MSNs-CTS-PNA. This tiered functionalization synergistically combines structural stability, pH and temperature stimuli-responsiveness, and biocompatibility. The ethane-bridged MSNs synthesis provides a rigid, porous framework for high drug loading, while CTS coating greatly boosts biocompatibility and prolongs circulation time. The optimized shell thickness balances high encapsulation efficiency and controlled drug release. These innovations make MSNs-CTS-PNA an advanced platform for targeted, combination, and environmentally adaptive drug delivery.
Acknowledgments
The authors thank for the support of the Special Fund for the Advantageous and Characteristic Disciplines (Group) of Hubei Province.
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Research ethics: The local Institutional Review Board deemed the study exempt from review.
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Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.
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Author contributions: K.Z. designed the experiment, conducted data curation, drafted the manuscript, supervised the project, and acquired funding. L.X. conceptualized the study, developed the software, and visualized the data. Q.X. contributed to methodology and software development. Y.L. conducted the investigation. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: The authors utilized OpenAI’s ChatGPT to assist in drafting and editing sections of this manuscript, such as refining language and formatting. All content generated by AI tools was critically reviewed and verified by the authors to ensure its accuracy and alignment with the research objectives.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: This work was supported by the Special Fund of Advantageous and Characteristic Disciplines (Group) of Hubei Province, and the Outstanding Young and Middle-aged Scientific and Technological Innovation Team Project of Colleges and Universities in Hubei Province (T2022049).
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Data availability: The raw data can be obtained from the corresponding author upon request.
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© 2025 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Material Properties
- Study on grasping performance of a novel flexible-rod structure for an inner grasper on a soft gripper
- Hybrid mesoporous silica composite nano drug carrier modified by CTS-poly(NIPAM-co-AA)
- Chlorine-driven phase dispersion, crystal growth, and morphological variation in thin films of biodegradable poly (ε-caprolactone) and chlorinated polyethylene binary blends
- Preparation and Assembly
- Controllable speed absorbing polyacrylamide hydrogels synthesized by the method of frontal polymerization
- Response surface methodology: an optimization approach for the synthesis of guar gum nanoparticles
- Chitosan surface coating modified submicron ordered porous zirconia
- Engineering and Processing
- Sustainable polymer composites: tuning PLA/recycled-ABS blends for a circular economy
- Filtration loss mechanisms of polyacrylamide-based copolymers in high-temperature drilling fluid
Articles in the same Issue
- Frontmatter
- Material Properties
- Study on grasping performance of a novel flexible-rod structure for an inner grasper on a soft gripper
- Hybrid mesoporous silica composite nano drug carrier modified by CTS-poly(NIPAM-co-AA)
- Chlorine-driven phase dispersion, crystal growth, and morphological variation in thin films of biodegradable poly (ε-caprolactone) and chlorinated polyethylene binary blends
- Preparation and Assembly
- Controllable speed absorbing polyacrylamide hydrogels synthesized by the method of frontal polymerization
- Response surface methodology: an optimization approach for the synthesis of guar gum nanoparticles
- Chitosan surface coating modified submicron ordered porous zirconia
- Engineering and Processing
- Sustainable polymer composites: tuning PLA/recycled-ABS blends for a circular economy
- Filtration loss mechanisms of polyacrylamide-based copolymers in high-temperature drilling fluid
