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Preparation and evaluation of polyvinyl alcohol hydrogels with zinc oxide nanoparticles as a drug controlled release agent for a hydrophilic drug

  • Azin Paydayesh EMAIL logo , Shirin Soltani and Arezoo Sh Dadkhah ORCID logo
Published/Copyright: June 15, 2023
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Journal of Polymer Engineering
From the journal Journal of Polymer Engineering Volume 43 Issue 7

Abstract

We report the preparation and application of ZnO/PVA nanocomposite hydrogel containing diclofenac sodium drug (DS) as a drug delivery system. The purpose of designing the nanocomposite hydrogels is to reduce the frequency of use and its side effects, and increase the effect of the drug. The desired nanocomposite hydrogel were prepared through the freezing–melting cycle. The structure and morphology were determined by FTIR and SEM, respectively. The gel fraction increased with adding the nanoparticles, from 67.49 % to 97.69 %. This amount also reaches 97.97 % by adding the drug. The degree of swelling decreased with increasing the amounts of nanoparticles and DS (998 % for PVA-710 % for 1 wt% DS). Based on the result of antibacterial properties and biocompatibility, the inhibition zones around the sample were about 2 mm for Staphylococcus aureus and for Escherichia coli. The cell viability of hydrogel increased from 66.02 % to 79.84 % with increasing the amount of DS. The biodegradation of PVA, is also higher (5–27.17 %) than ZnO/PVA with (3.8–20.2 %) and without (4–23.53 %) drug. The modeling results showed that Peppas–Korsmeyer is a good model for DS release from ZnO/PVA and the diffusion mechanism of DS is Fickian. In this way, we introduced an effective system for drug delivery.

Keywords: drug release; nanocomposite hydrogel; polyvinyl alcohol
Corresponding author: Azin Paydayesh, Department of Chemical Engineering, Islamic Azad University, Mahshahr Branch, Mahshahr 6351977439, Iran, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/polyeng-2023-0011).

Received: 2023-01-10
Accepted: 2023-05-29
Published Online: 2023-06-15
Published in Print: 2023-08-28

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

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  2. Material Properties
  3. The degradation behaviors of optical cellulose triacetate films in alkali/acid solutions
  4. Exploration of dielectric spectra of variously synthesized epoxy/ZnO nanocomposites
  5. Preparation and Assembly
  6. Preparation and evaluation of polyvinyl alcohol hydrogels with zinc oxide nanoparticles as a drug controlled release agent for a hydrophilic drug
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  10. Engineering and Processing
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https://doi.org/10.1515/polyeng-2023-0011
Keywords for this article
drug release; nanocomposite hydrogel; polyvinyl alcohol

Articles in the same Issue

  1. Frontmatter
  2. Material Properties
  3. The degradation behaviors of optical cellulose triacetate films in alkali/acid solutions
  4. Exploration of dielectric spectra of variously synthesized epoxy/ZnO nanocomposites
  5. Preparation and Assembly
  6. Preparation and evaluation of polyvinyl alcohol hydrogels with zinc oxide nanoparticles as a drug controlled release agent for a hydrophilic drug
  7. PVA-borax/g-C3N4 nanocomposite hydrogel with excellent mechanical property and self-healing efficiency
  8. Fabrication and characterization of microencapsulated dimethyl adipate phase change material with melamine-formaldehyde shell for cold thermal energy storage in coating
  9. Preparation and performance of “three-layer sandwich” composite loose nanofiltration membrane based on mussel bionic technology
  10. Engineering and Processing
  11. Electrospinning and electrospun based polyvinyl alcohol nanofibers utilized as filters and sensors in the real world
  12. Synergistic effect of GMA and TMPTA as co-agent to adjust the branching structure of PLLA during UV-induced reactive extrusion
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