The effect of the preparation process on the swelling behavior of silk fibroin-polyurethane composite hydrogels using a full factorial experimental design
-
Ling Cai
and
Xiangjin Lin
Abstract
Polyurethane prepolymer (PUP) was synthesized by polyethylene glycol (PEG) and polypropylene glycol (PPG) as the soft segments, isophorone diisocyanate (IPDI) as the hard segment and dimethylol propionic acid (DMPA) and diethylene glycol (DEG) as chain extenders. Silk fibroin (SF)-PU composite hydrogels were prepared by SF and PUP through chemical crosslinking and physical crosslinking interactions. A full factorial experimental design with four factors and four levels was applied to optimize the craft of preparing SF-PU composite hydrogels. The molecular weight of PEG, IPDI/(PEG+PPG) (molar ratio), PEG/(PEG+PPG) (molar ratio) and SF/(SF+PU) (mass ratio) were the factors. The swelling behavior of hydrogels was tested in deionized water at 30°C. The results showed that the equilibrium swelling ratio (ESR) was the largest by tuning the molecular weight of PEG to 4000, IPDI/(PEG+PPG)(molar ratio) to 3, PEG/(PEG+PPG) (molar ratio) to 40% and SF/(SF+PU) (mass ratio) to 2%. Fickian diffusion played a dominant role in the initial stage of swelling. For the whole process, the results fitted well into the Schott second-order kinetic equation.
Acknowledgments
This paper was supported by a fund from the Ministry of Health of China (WKJ-ZJ-12) and a fund from Health Bureau of Zhejiang Province (2013KYB098).
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©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Original articles
- Preparation and application of fluorinated-siloxane protective surface coating material for stone inscriptions
- The effect of the preparation process on the swelling behavior of silk fibroin-polyurethane composite hydrogels using a full factorial experimental design
- Synthesis of cashew Mannich polyol via a three step continuous route and development of PU rigid foams with mechanical, thermal and fire studies
- Effect of chemical treatment on the mechanical and water absorption properties of bagasse fiber-reinforced epoxy composites
- Environmentally degradable sago starch filled low-density polyethylene
- The effect of hybrid nanoparticle with silica sol as the supporter on the crystallization behavior and mechanical properties of isotactic polypropylene
- Towards novel wound dressings: antibacterial properties of zinc oxide nanoparticles and electrospun fiber mats of zinc oxide nanoparticle/poly(vinyl alcohol) hybrids
- Nanofiber formation in the presence of an external magnetic field in electrospinning
- Preparation and characterization emulsion of PANI-TiO2 nanocomposite and its application as anticorrosive coating
- The effect of the geometry of extrusion head flow channels on the adiabatic extrusion of low density polyethylene
Articles in the same Issue
- Frontmatter
- Original articles
- Preparation and application of fluorinated-siloxane protective surface coating material for stone inscriptions
- The effect of the preparation process on the swelling behavior of silk fibroin-polyurethane composite hydrogels using a full factorial experimental design
- Synthesis of cashew Mannich polyol via a three step continuous route and development of PU rigid foams with mechanical, thermal and fire studies
- Effect of chemical treatment on the mechanical and water absorption properties of bagasse fiber-reinforced epoxy composites
- Environmentally degradable sago starch filled low-density polyethylene
- The effect of hybrid nanoparticle with silica sol as the supporter on the crystallization behavior and mechanical properties of isotactic polypropylene
- Towards novel wound dressings: antibacterial properties of zinc oxide nanoparticles and electrospun fiber mats of zinc oxide nanoparticle/poly(vinyl alcohol) hybrids
- Nanofiber formation in the presence of an external magnetic field in electrospinning
- Preparation and characterization emulsion of PANI-TiO2 nanocomposite and its application as anticorrosive coating
- The effect of the geometry of extrusion head flow channels on the adiabatic extrusion of low density polyethylene
