Abstract:
The assessment of photoaging is a huge component not only in clinical practice, but also in human research studies geared towards anti-aging therapies, photoprotection or mechanistic studies to understand the effects of ultraviolet light on the skin. However, evaluation remains difficult to standardize. Photonumeric scales are superior to descriptive evaluations, and have been used with some validity and reproducibility. Newer techniques that employ more sophisticated imaging modalities may be necessary. In addition, consideration of skin color, ethnicity, gender, and specific anatomic regions of the face play a role in the evaluation.
Zusammenfassung:
Die Beurteilung des sogenannten Photoagings spielt eine große Rolle – nicht nur in der klinischen Praxis, sondern auch in mechanistischen sowie klinischen Studien zu Anti-Aging-Therapien und Lichtschutz, die darauf ausgerichtet sind, die Auswirkungen von UV-Licht auf die Haut zu verstehen. Allerdings ist eine standardisierte Auswertung nachwievor schwierig. Photonumerische Skalen sind der deskriptiven Evaluation überlegen und erwiesen sich vielfach als valide und reproduzierbar. Dennoch scheint der Einsatz neuerer Techniken, die komplexere Bildgebungsverfahren verwenden, notwendig. Darüber hinaus spielen die Berücksichtigung der Hautfarbe, der ethnischen Zugehörigkeit, des Geschlechts sowie bestimmter anatomischer Regionen des Gesichts eine Rolle bei der Bewertung.
References
[1] Kohl E, Steinbauer J, Landthaler M, Szeimies RM. Skin ageing. J Eur Acad Dermatol Venereol 2011;25(8):873–84.10.1111/j.1468-3083.2010.03963.xSearch in Google Scholar PubMed
[2] Yaar M, Gilchrest BA. Photoageing: mechanism, prevention, and therapy. Br J Dermatol 2007;157(5):874–87.10.1111/j.1365-2133.2007.08108.xSearch in Google Scholar PubMed
[3] El-Domyati M, Attia S, Saleh F, Brown D, Birk DE, Gasparro F, Ahmad H, Uitto J. Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp Dermatol 2002;11(5):398–405.10.1034/j.1600-0625.2002.110502.xSearch in Google Scholar PubMed
[4] Marini A, Farwick M, Grether-Beck S, Brenden H, Felsner I, Jaenicke T, Weber M, Schild J, Maczkiewitz U, Köhler T, Bonfigli A, Pagani V, Krutmann J. Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects. Exp Dermatol 2012;21(2):140–6.10.1111/j.1600-0625.2011.01415.xSearch in Google Scholar PubMed
[5] Vierkötter A, Ranft U, Krämer U, Sugiri D, Reimann V, Krutmann J. The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing. J Dermatol Sci 2009;53(3):207–11.10.1016/j.jdermsci.2008.10.001Search in Google Scholar PubMed
[6] Valet F, Ezzedine K, Malvy D, Mary JY, Guinot C. Assessing quality of ordinal scales depicting skin aging severity. In: Farage MA, Miller KW, Maibach HI, editors. Textbook of aging skin. Berlin: Springer-Verlag; 2010, p. 921–8.10.1007/978-3-540-89656-2_87Search in Google Scholar
[7] Shoshani D, Markovitz E, Monstrey SJ, Narins DJ. The modified Fitzpatrick Wrinkle Scale: a clinical validated measurement tool for nasolabial wrinkle severity assessment. Dermatol Surg 2008;34(Suppl 1):S85–91; discussion S91.10.1111/j.1524-4725.2008.34248.xSearch in Google Scholar PubMed
[8] Leyden JJ. Clinical features of ageing skin. Br J Dermatol 1990;122(Suppl 35):1–3.10.1111/j.1365-2133.1990.tb16118.xSearch in Google Scholar PubMed
[9] Lim HW, Hönigsmann H, Hawk JLM, editors. Photodermatology. New York: Informa Healthcare USA, Inc.; 2007.10.3109/9781420019964Search in Google Scholar
[10] Baumann L. Skin ageing and its treatment. J Pathol 2007;211(2):241–51.10.1002/path.2098Search in Google Scholar PubMed
[11] Yaar M, Gilchrest BA. Aging of skin. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s dermatology in general medicine. 8th ed. New York, Chicago and San Francisco: McGraw-Hill Medical; 2012, p. 1213–27.Search in Google Scholar
[12] Bhawan J, Andersen W, Lee J, Labadie R, Solares G. Photoaging versus intrinsic aging: a morphologic assessment of facial skin. J Cutan Pathol 1995;22(2):154–9.10.1111/j.1600-0560.1995.tb01399.xSearch in Google Scholar
[13] Rabe JH, Mamelak AJ, McElgunn PJ, Morison WL, Sauder DN. Photoaging: mechanisms and repair. J Am Acad Dermatol 2006;55(1):1–19.10.1016/j.jaad.2005.05.010Search in Google Scholar
[14] Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ. Mechanisms of photoaging and chronological skin aging. Arch Dermatol 2002;138(11):1462–70.10.1001/archderm.138.11.1462Search in Google Scholar
[15] Sjerobabski Masnec I, Poduje S. Photoaging. Coll Antropol 2008;32(Suppl 2):177–80.Search in Google Scholar
[16] Malvy Jm, Guinot C, Preziosi P, Vaillant L, Tenenhaus M, Galan P, Hercberg S, Tschachler E. Epidemiologic determinants of skin photoaging: baseline data of the SU.VI.MAX. cohort. J Am Acad Dermatol 2000;42(1 Pt 1):47–55.10.1016/S0190-9622(00)90008-2Search in Google Scholar
[17] Malbasa CL, Baron ED, Fu P, Matsui MS, Fthenakis C, Vanderover G, Cummins P, Cooper KD. Spectral imaging detects physiologic parameters that contribute to photoaging among twins. Poster presentation at the Society of Investigative Dermatology (SID) 2011 Annual Meeting, May 4–7, 2011, Phoenix, AZ, USA. http://www.sidnet.org/Admin/UserFiles/File/FINAL%202011%20Meeting%20Program.pdf [Accessed on July 2, 2013].Search in Google Scholar
[18] Martires KJ, Fu P, Polster AM, Cooper KD, Baron ED. Factors that affect skin aging: a cohort-based survey on twins. Arch Dermatol 2009;145(12):1375–9.10.1001/archdermatol.2009.303Search in Google Scholar PubMed
[19] Bernois A, Huber A, Derome C, Drouault Y, de Quéral D, Schnebert S, Perrier E, Heusèle C. A photographic scale for the evaluation of facial skin aging in Indian women. Eur J Dermatol 2011;21(5):700–4.10.1684/ejd.2011.1462Search in Google Scholar PubMed
[20] Alexis AF, Rossi A. Photoaging in skin of color. Cosmet Dermatol 2011;24(8):367–70.Search in Google Scholar
[21] Gibson JR, van Schie PM. Clinical trial measuring systems in dermatology. In: Maibach H, Bashir SJ, McKibbon A, editors. Evidence-based dermatology. Lewiston, NY: BC Decker Inc.; 2002, p. 113–20.Search in Google Scholar
[22] Bosset S, Bonnet-Duquennoy M, Barré P, Chalon A, Kurfurst R, Bonté F, Schnébert S, Le Varlet B, Nicolas JF. Photoageing shows histological features of chronic skin inflammation without clinical and molecular abnormalities. Br J Dermatol 2003;149(4):826–35.10.1046/j.1365-2133.2003.05456.xSearch in Google Scholar PubMed
[23] Day DJ, Littler CM, Swift RW, Gottlieb S. The wrinkle severity rating scale: a validation study. Am J Clin Dermatol 2004;5(1):49–52.10.2165/00128071-200405010-00007Search in Google Scholar PubMed
[24] Carruthers A, Carruthers J. A validated facial grading scale: the future of facial ageing measurement tools? J Cosmet Laser Ther 2010;12(5):235–41.10.3109/14764172.2010.514920Search in Google Scholar PubMed
[25] Marks R, Edwards C. The measurement of photodamage. Br J Dermatol 1992;127(Suppl 41):7–13.10.1111/j.1365-2133.1992.tb16981.xSearch in Google Scholar PubMed
[26] Griffiths CE, Wang TS, Hamilton TA, Voorhees JJ, Ellis CN. A photonumeric scale for the assessment of cutaneous photodamage. Arch Dermatol 1992;128(3):347–51.10.1001/archderm.1992.01680130061006Search in Google Scholar
[27] Larnier C, Ortonne JP, Venot A, Faivre B, Béani JC, Thomas P, Brown TC, Sendagorta E. Evaluation of cutaneous photodamage using a photographic scale. Br J Dermatol 1994;130(2):167–73.10.1111/j.1365-2133.1994.tb02895.xSearch in Google Scholar
[28] Lemperle G, Holmes RE, Cohen SR, Lemperle SM. A classification of facial wrinkles. Plast Reconstr Surg 2001;108(6):1735–50; discussion 1751–2.10.1097/00006534-200111000-00050Search in Google Scholar
[29] Glogau RG. Aesthetic and anatomic analysis of the aging skin. Semin Cutan Med Surg 1996;15(3):134–8.10.1016/S1085-5629(96)80003-4Search in Google Scholar
[30] Fitzpatrick RE, Goldman MP, Satur NM, Tope WD. Pulsed carbon dioxide laser resurfacing of photo-aged facial skin. Arch Dermatol 1996;132(4):395–402.10.1001/archderm.1996.03890280047007Search in Google Scholar
[31] Valet F, Ezzedine K, Malvy D, Mary JY, Guinot C. Assessing the reliability of four severity scales depicting skin ageing features. Br J Dermatol 2009;161(1):153–8.10.1111/j.1365-2133.2009.09148.xSearch in Google Scholar PubMed
[32] Viera AJ, Garrett JM. Understanding interobserver agreement: the kappa statistic. Fam Med 2005;37(5):360–3.Search in Google Scholar
[33] Vierkötter A, Schikowski T, Ranft U, Sugiri D, Matsui M, Krämer U, Krutmann J. Airborne particle exposure and extrinsic skin aging. J Invest Dermatol 2010;130(12):2719–26.10.1038/jid.2010.204Search in Google Scholar PubMed
[34] Carruthers A, Carruthers J, Hardas B, Kaur M, Goertelmeyer R, Jones D, Rzany B, Cohen J, Kerscher M, Flynn TC, Maas C, Sattler G, Gebauer A, Pooth R, McClure K, Simone-Korbel U, Buchner L. A validated hand grading scale. Dermatol Surg 2008;34(Suppl 2):S179–83.10.1111/j.1524-4725.2008.34368.xSearch in Google Scholar PubMed
[35] Monheit GD, Gendler EC, Poff B, Fleming L, Bachtell N, Garcia E, Burkholder D. Development and validation of a 6-point grading scale in patients undergoing correction of nasolabial folds with a collagen implant. Dermatol Surg 2010;36(Suppl 3):1809–16.10.1111/j.1524-4725.2010.01739.xSearch in Google Scholar PubMed
[36] Tsukahara K, Takema Y, Kazama H, Yorimoto Y, Fujimura T, Moriwaki S, Kitahara T, Kawai M, Imokawa G. A photographic scale for the assessment of human facial wrinkles. J Cosmet Sci 2000;51:127–39.Search in Google Scholar
[37] Jones D. Commentary: are aesthetic grading scales on a research tool? Dermatol Surg 2010;36(Suppl. 3):1817–8.10.1111/j.1524-4725.2010.01793.xSearch in Google Scholar
[38] Richard S, de Rigal J, de Lacharriere O, Berardesca E, Leveque JL. Noninvasive measurement of the effect of lifetime exposure to the sun on the aged skin. Photodermatol Photoimmunol Photomed 1994;10(4):164–9.Search in Google Scholar
[39] Raphael AP, Kelf TA, Wurm EM, Zvyagin AV, Soyer HP, Prow TW. Computational characterization of reflectance confocal microscopy features reveals potential for automated photoageing assessment. Exp Dermatol 2013;22(7):458–63.10.1111/exd.12176Search in Google Scholar PubMed
[40] Hoffmann K, Dirschka TP, Stücker M, el-Gammal S, Altmeyer P. Assessment of actinic skin damage by 20-MHz sonography. Photodermatol Photoimmunol Photomed 1994;10(3):97–101.Search in Google Scholar
[41] Kollias N, Gillies R, Moran M, Kochevar IE, Anderson RR. Endogenous skin fluorescence includes bands that may serve as quantitative markers of aging and photoaging. J Invest Dermatol 1998;111(5):776–80.10.1046/j.1523-1747.1998.00377.xSearch in Google Scholar PubMed
[42] Tian WD, Gillies R, Brancaleon L, Kollias N. Aging and effects of ultraviolet A exposure may be quantified by fluorescence excitation spectroscopy in vivo. J Invest Dermatol 2001;116(6):840–5.10.1046/j.1523-1747.2001.01361.xSearch in Google Scholar PubMed
[43] Jacques SL, Samatham R, Choudhury N. Rapid spectral analysis for spectral imaging. Biomed Opt Express 2010;1(1):157–64.10.1364/BOE.1.000157Search in Google Scholar PubMed PubMed Central
[44] Miyamae Y, Yamakawa Y, Kawabata M, Ozaki Y. A combined near-infrared diffuse reflectance spectroscopy and principal component analysis method of assessment for the degree of photoaging and physiological aging of human skin. Anal Sci 2012;28(12):1159–64.10.2116/analsci.28.1159Search in Google Scholar PubMed
[45] Miyamae Y, Yamakawa Y, Kawabata M, Ozaki Y. A noninvasive method for assessing interior skin damage caused by chronological aging and photoaging based on near-infrared diffuse reflection spectroscopy. Appl Spectrosc 2008;62(6):677–81.10.1366/000370208784658156Search in Google Scholar PubMed
[46] González FJ, Castillo-Martínez C, Martínez-Escanamé M, Ramírez-Elías MG, Gaitan-Gaona FI, Oros-Ovalle C, Moncada B. Noninvasive estimation of chronological and photoinduced skin damage using Raman spectroscopy and principal component analysis. Skin Res Technol 2012;18(4):442–6.10.1111/j.1600-0846.2011.00591.xSearch in Google Scholar PubMed
[47] Bae Y, Nelson JS, Jung B. Multimodal facial color imaging modality for objective analysis of skin lesions. J Biomed Opt 2008;13(6):064007.10.1117/1.3006056Search in Google Scholar PubMed PubMed Central
[48] Wurm EM, Longo C, Curchin C, Soyer HP, Prow TW, Pellacani G. In vivo assessment of chronological ageing and photoageing in forearm skin using reflectance confocal microscopy. Br J Dermatol 2012;167(2):270–9.10.1111/j.1365-2133.2012.10943.xSearch in Google Scholar PubMed
[49] Sanchez WY, Obispo C, Ryan E, Grice JE, Roberts MS. Changes in redox state and endogenous fluorescence of in vivo human skin due to intrinsic and photo-aging, measured by multiphoton tomography with fluorescence lifetime imaging. J Biomed Opt 2013;18(6):061217.10.1117/1.JBO.18.6.061217Search in Google Scholar PubMed
[50] Lin SJ, Wu R Jr, Tan HY, Lo W, Lin WC, Young TH, Hsu CJ, Chen JS, Jee SH, Dong CY. Evaluating cutaneous photoaging by use of multiphoton fluorescence and second-harmonic generation microscopy. Opt Lett 2005;30(17):2275–7.10.1364/OL.30.002275Search in Google Scholar
©2013 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Progress in dermatology
- Editors’ note
- Reviewer acknowledgement
- Magazine section
- Snapshots
- Reviews
- Reflectance confocal microscopy: A new tool in skin oncology
- Techniques for fluorescence detection of protoporphyrin IX in skin cancers associated with photodynamic therapy
- Evaluation and assessment of photoaging
- Laser ablation-enhanced transdermal drug delivery
- Spectral in vivo signature of carotenoids in visible light diffuse reflectance from skin in comparison to ex vivo absorption spectra
- Registration of scattered laser images and radiographs of small finger joints
- Preliminary research report
- Helium-neon laser therapy interferes with epiphyseal plate growth in the femur and tibia of rabbits
- Announcement
- Protokoll der Mitgliederversammlung der Deutschen Gesellschaft für Lasermedizin (DGLM) e.V.
- Congress report
- LASER World of PHOTONICS – DGLM Application Panel
- Congresses 2013/2014
- Contents of the Volume
Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Progress in dermatology
- Editors’ note
- Reviewer acknowledgement
- Magazine section
- Snapshots
- Reviews
- Reflectance confocal microscopy: A new tool in skin oncology
- Techniques for fluorescence detection of protoporphyrin IX in skin cancers associated with photodynamic therapy
- Evaluation and assessment of photoaging
- Laser ablation-enhanced transdermal drug delivery
- Spectral in vivo signature of carotenoids in visible light diffuse reflectance from skin in comparison to ex vivo absorption spectra
- Registration of scattered laser images and radiographs of small finger joints
- Preliminary research report
- Helium-neon laser therapy interferes with epiphyseal plate growth in the femur and tibia of rabbits
- Announcement
- Protokoll der Mitgliederversammlung der Deutschen Gesellschaft für Lasermedizin (DGLM) e.V.
- Congress report
- LASER World of PHOTONICS – DGLM Application Panel
- Congresses 2013/2014
- Contents of the Volume