The role of neuroimmune interactions in musculoskeletal pain
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Hans-Georg Schaible
Hans-Georg Schaible studied medicine at the Universities of Tübingen and Hamburg. After habilitation and a Heisenberg fellowship he became associate professor at the Institute of Physiology of the University of Würzburg, and 1997 he became full professor of physiology and director of the Institute of Physiology1/Neurophysiology at the University of Jena, Germany. Scientifically, Hans-Georg Schaible and his team work on the neurobiological mechanisms of joint pain. Hans-Georg Schaible was the chair of two German research consortia (2010–2020) addressing the effect of the immune system on the nervous system and the effect of the nervous system on immune processes in the joint. Currently he is a principal investigator in the EU consortium TOBeATPAIN (2018–2022).
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Andrea Ebersberger
Andrea Ebersberger studied biology and finished her diploma at the Department of Zoology (Friedrich-Alexander-University Erlangen-Nürnberg). Then she changed to the Department of Physiology and Experimental Pathophysiology at the Medical Faculty of the University Erlangen-Nürnberg (Chair: Prof. Dr. H.O. Handwerker), to study pain mechanisms in the trigeminal system. As a Post Doc she worked at the Department of Physiology, University of Würzburg, Topic: Joint pain and headache. Since 1997 she has been a senior scientist at the Department of Neurophysiology, Friedrich-Schiller-University of Jena where she finished her ‘Habilitation’ in 2003. Scientifically she concentrates on inflammatory mediators and cytokines in the sensitization process of peripheral and central nociceptive neurons using
in vivo andin vitro approaches.
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Gabriel Natura
Gabriel Natura studied physics at the University of Jena. He completed his PhD in 1999 at the Institute of Biophysics and Biochemistry, University of Jena. After the Ph.D. he was a postdoc. at the Botanical Institute of the University of Karlsruhe 1999–2001. Then he went to the Institute of Physiology I of the University of Jena. His field of work and experience include electrophysiological research on ion channels of isolated cell membranes (plant, yeast, and animal cells) by patch clamp technique. At present he studies how proinflammatory cytokines alter the excitability of peripheral sensory neurons.
and
Enrique Vazquez
Enrique Vazquez Rodriguez studied Biology in Caracas, Venezuela. He obtained a Master in Neurosciences and a PhD in Biology, Major in Physiology and Biophysics at Venezuelan Institute for Scientific Research (IVIC). He was Post-Doc and Associate Professor at the Laboratory of Neuroscience (until 2018), also Coordinator of the Physiology and Biophysics postgraduate course and Head of the Neurophysiology laboratory (IVIC, until 2018). He held DAAD and Humboldt Research fellowships. Currently he belongs to the scientific staff of the Institute of Physiology I, Klinikum of the University of Jena (from 2018). He works on mechanisms of pain generation and pain inhibition in the peripheral and central nervous system.
Abstract
Interactions of the immune system and the nociceptive system play an important role in the generation and maintenance of pain in musculoskeletal diseases and in disease development. In inflamed tissue peripheral nociceptive neurons are rendered hyperexcitable by proinflammatory cytokines, antigen/antibody complexes and other immune mediators. Spinal nociceptive neurons are rendered hyperexcitable with the support of microglial cells, the immune cells of the central nervous system. The so-elicited sensitization of pain pathways has a strong impact on pain processing in the brain. On the other hand, immune processes are regulated by the nervous system. Sensory neurons, by releasing neuropeptides, and efferent neurons of the sympathetic nervous system support immune processes which promote disease development.
Zusammenfassung
Interaktionen zwischen dem Immunsystem und dem nozizeptiven System spielen eine wichtige Rolle in der Erzeugung und Aufrechterhaltung von Schmerzen bei muskuloskelettalen Erkrankungen und bei der Entwicklung dieser Krankheiten. Im entzündeten Gewebe erzeugen proinflammatorische Zytokine, Antigen-Antikörper-Komplexe und andere Immunmediatoren eine Übererregbarkeit peripherer nozizeptiver Neurone. Im Rückenmark entsteht durch Unterstützung der Microglia, den Immunzellen des Zentralnervensystems, eine Übererregbarkeit spinaler nozizeptiver Neurone. Die dadurch ausgelöste Sensibilisierung der nozizeptiven Bahnen hat einen starken Einfluss auf die Schmerzentstehung im Gehirn. Andererseits werden Immunprozesse durch das Nervensystem reguliert. Sensorische Neurone, die Neuropeptide freisetzen, und efferente Fasern des sympathischen Nervensystems unterstützen die Immunprozesse, die die Krankheitsentwicklung vorantreiben.
Funding source: Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
Award Identifier / Grant number: SCHA 404/18-1
Funding source: Bundesministerium für Bildung und Forschung
Award Identifier / Grant number: Neuroimpa
Funding source: European Commission http://dx.doi.org/10.13039/501100000780
Award Identifier / Grant number: TOBeATPAIN
About the authors
Hans-Georg Schaible studied medicine at the Universities of Tübingen and Hamburg. After habilitation and a Heisenberg fellowship he became associate professor at the Institute of Physiology of the University of Würzburg, and 1997 he became full professor of physiology and director of the Institute of Physiology1/Neurophysiology at the University of Jena, Germany. Scientifically, Hans-Georg Schaible and his team work on the neurobiological mechanisms of joint pain. Hans-Georg Schaible was the chair of two German research consortia (2010–2020) addressing the effect of the immune system on the nervous system and the effect of the nervous system on immune processes in the joint. Currently he is a principal investigator in the EU consortium TOBeATPAIN (2018–2022).
Andrea Ebersberger studied biology and finished her diploma at the Department of Zoology (Friedrich-Alexander-University Erlangen-Nürnberg). Then she changed to the Department of Physiology and Experimental Pathophysiology at the Medical Faculty of the University Erlangen-Nürnberg (Chair: Prof. Dr. H.O. Handwerker), to study pain mechanisms in the trigeminal system. As a Post Doc she worked at the Department of Physiology, University of Würzburg, Topic: Joint pain and headache. Since 1997 she has been a senior scientist at the Department of Neurophysiology, Friedrich-Schiller-University of Jena where she finished her ‘Habilitation’ in 2003. Scientifically she concentrates on inflammatory mediators and cytokines in the sensitization process of peripheral and central nociceptive neurons using in vivo and in vitro approaches.
Gabriel Natura studied physics at the University of Jena. He completed his PhD in 1999 at the Institute of Biophysics and Biochemistry, University of Jena. After the Ph.D. he was a postdoc. at the Botanical Institute of the University of Karlsruhe 1999–2001. Then he went to the Institute of Physiology I of the University of Jena. His field of work and experience include electrophysiological research on ion channels of isolated cell membranes (plant, yeast, and animal cells) by patch clamp technique. At present he studies how proinflammatory cytokines alter the excitability of peripheral sensory neurons.
Enrique Vazquez Rodriguez studied Biology in Caracas, Venezuela. He obtained a Master in Neurosciences and a PhD in Biology, Major in Physiology and Biophysics at Venezuelan Institute for Scientific Research (IVIC). He was Post-Doc and Associate Professor at the Laboratory of Neuroscience (until 2018), also Coordinator of the Physiology and Biophysics postgraduate course and Head of the Neurophysiology laboratory (IVIC, until 2018). He held DAAD and Humboldt Research fellowships. Currently he belongs to the scientific staff of the Institute of Physiology I, Klinikum of the University of Jena (from 2018). He works on mechanisms of pain generation and pain inhibition in the peripheral and central nervous system.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This work was funded by the Deutsche Forschungsgemeinschaft (DFG) (SCHA 404/18-1), the Bundesministerium für Bildung und Forschung (BMBF) (Neuroimpa) and the European Union (EU) (TOBeATPAIN).
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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Articles in the same Issue
- Frontmatter
- Editorial
- Editorial
- Review articles
- Genetics meets function in sodium channel-related pain disorders
- The role of neuroimmune interactions in musculoskeletal pain
- Glial cells as target for antidepressants in neuropathic pain
- Brain-based interventions for chronic pain
- Pain, the brain, and SARS-CoV-2: evidence for pain-specific alterations in brain-related structure–function properties
- Obituary
- Hans-Joachim Pflüger – scientist, citizen, cosmopolitan
- Nachrichten aus der Gesellschaft
- Nachrichten aus der Gesellschaft
Articles in the same Issue
- Frontmatter
- Editorial
- Editorial
- Review articles
- Genetics meets function in sodium channel-related pain disorders
- The role of neuroimmune interactions in musculoskeletal pain
- Glial cells as target for antidepressants in neuropathic pain
- Brain-based interventions for chronic pain
- Pain, the brain, and SARS-CoV-2: evidence for pain-specific alterations in brain-related structure–function properties
- Obituary
- Hans-Joachim Pflüger – scientist, citizen, cosmopolitan
- Nachrichten aus der Gesellschaft
- Nachrichten aus der Gesellschaft
