Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation
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Fatemeh Tara
Abstract
Objective: We assessed the impact of selenium, a trace element with antioxidant properties on a simple measure of oxidative stress in pregnant women.
Study design: A novel assay of prooxidant-antioxidant balance (PAB) was applied in a double-blind, placebo-controlled study of selenium supplementation in pregnancy. We measured the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby calculating a redox index. A total of 166 primigravid pregnant women in the first trimester of pregnancy, were randomized to receive 100 μg of selenium (n=83) or placebo (n=83) per day until delivery. PAB values and serum selenium concentrations were measured at baseline and at the end of study.
Results: Pretreatment demographic data and biochemical indices including serum selenium concentrations did not differ significantly between the groups. The drop-out rates for the groups were 22/83 and 19/83 for the selenium and placebo groups, respectively. Supplementation with selenium was associated with a significant increase in mean serum selenium concentration (P<0.001) but without significant change in mean PAB value. In contrast, mean serum selenium concentration remained unchanged and mean PAB values increased significantly (P<0.05 in the control group).
Conclusion: Our findings suggest that selenium supplementation may reduce oxidative stress associated with pregnancy.
©2010 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Review article
- Monochorionic twin pregnancy: screening, pathogenesis of complications and management in the era of microinvasive fetal surgery
- Original articles – Obstetrics
- Longitudinal examination of cervical volume and vascularization changes during the antepartum and postpartum period using three-dimensional and power Doppler ultrasound
- Uterine and umbilical artery Doppler velocimetry as a predictor for adverse pregnancy outcomes in pregnant women with anemia
- Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation
- Two-stage transvaginal cervical length screening for preterm birth in twin pregnancies
- The relationship between placental histology and cervical length in twin gestations
- A novel method for evaluating uterine cervical consistency using vaginal ultrasound gray-level histogram
- Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses
- Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods
- Original articles – Fetus
- Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats
- Calprotectin in human cord blood: relation to perinatal parameters and restricted fetal growth
- Original articles – Newborn
- Diagnostic value of interleukin-6 and C-reactive protein on early onset bacterial infection in preterm neonates with respiratory distress
- Simulated transport alters surfactant homeostasis and causes dose-dependent changes in respiratory function in neonatal Sprague-Dawley rats
- Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation
- Surfactant administration for neonatal respiratory distress does not improve lung interstitial fluid clearance: echographic and experimental evidence
- Letter to the editor
- Double aneuploidy of trisomy 18 and Klinefelter syndrome: prenatal diagnosis and perinatal outcome
- Congress Calender
- Congress Calendar
