Cholinergic signal activated renin angiotensin system associated with cardiovascular changes in the ovine fetus
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Chunsong Geng
Abstract
Aim: Cholinergic regulation is important in the control of cardiovascular and endocrine responses. The mechanisms behind cardiovascular responses induced by cholinergic activation are explored by studying hormonal systems, including renin-angiotensin and vasopressin (VP).
Results: In chronically prepared fetal sheep, intravenous infusion of the cholinergic agonist carbachol increased fetal systolic, diastolic, and mean arterial pressure accompanied with bradycardia at near-term. Although intravenous administration of carbachol had no effect on plasma VP concentrations, this agonist increased angiotensin I and angiotensin II levels in fetal plasma. Fetal blood values, including sodium, osmolality, nitric oxide, hemoglobin, and hematocrit were unchanged by intravenous carbachol.
Conclusion: Cholinergic activation by carbachol controls fetal blood pressure and heart rate in utero. An over-activated fetal renin-angiotensin-system (RAS) is associated with changes in vascular pressure following intravenous administration of carbachol, indicating that the cholinergic stimulation-mediated hormonal mechanism in the fetus might play a critical role in the regulation of cardiovascular homeostasis.
©2010 by Walter de Gruyter Berlin New York
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- The Declaration of Dubrovnik
- The prediction and prevention of preterm birth and its consequences: an unmet challenge to perinatal medicine, science and society
- Original articles – Obstetrics
- Women's attitudes to and perceptions of oral health and dental care during pregnancy
- Low circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infection
- Improving obstetric estimation of outcomes of extremely premature neonates: an evolving challenge
- Atosiban vs. ritodrine as a tocolytic in external cephalic version at term: a prospective cohort study
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- Roster of Perinatal Societies
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